| Autosomal Dominant Weill-Marchesani-Like Syndrome in a Chinese Family due to Novel Haplotypic Mutations in LTBP2. | Autosomal Dominant Weill-Marchesani-Like Syndrome in a Chinese Family due to Novel Haplotypic Mutations in LTBP2.
Chen J, Wan J, Jin J, Jin G, Zheng Y, Zheng D, Zhong L. | 06/18/2024 |
| Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis. | Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis.
Liu L, Guo D, Yang F, Qi H, Zhou Y, Zheng D, Jin G., Free PMC Article | 02/15/2024 |
| Plasma LTBP2 as a potential biomarker in differential diagnosis of connective tissue disease-associated interstitial lung disease and idiopathic pulmonary fibrosis: a pilot study. | Plasma LTBP2 as a potential biomarker in differential diagnosis of connective tissue disease-associated interstitial lung disease and idiopathic pulmonary fibrosis: a pilot study.
Zou M, Hu X, Song W, Gao H, Wu C, Zheng W, Cheng Z. | 12/23/2023 |
| LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway. | LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway.
Wang T, Zhou Z, Wang C, Qin Y, Wu L, Hu B, Jin Q, Wei W, Huang M., Free PMC Article | 09/10/2022 |
| The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies. | The prognostic significance of LTBP2 for malignant tumors: Evidence based on 11 observational studies.
Zhao J, Liu X, Cong K, Chang J, Shan H, Zheng Y., Free PMC Article | 05/14/2022 |
| CircWHSC1 expedites cervical cancer progression via miR-532-3p/LTBP2 axis. | CircWHSC1 expedites cervical cancer progression via miR-532-3p/LTBP2 axis.
Li Y, Meng F, Sui C, Wang Y, Cheng D. | 05/14/2022 |
| Latent TGFbeta-binding proteins regulate UCP1 expression and function via TGFbeta2. | Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2.
Halbgebauer D, Roos J, Funcke JB, Neubauer H, Hamilton BS, Simon E, Amri EZ, Debatin KM, Wabitsch M, Fischer-Posovszky P, Tews D., Free PMC Article | 03/26/2022 |
| An Insight into Primary Congenital Glaucoma. | An Insight into Primary Congenital Glaucoma.
Khan MU, Zia MUQ, Tabassum W. | 07/17/2021 |
| Novel mutations of TCTN3/LTBP2 with cellular function changes in congenital heart disease associated with polydactyly. | Novel mutations of TCTN3/LTBP2 with cellular function changes in congenital heart disease associated with polydactyly.
Chen HX, Yang ZY, Hou HT, Wang J, Wang XL, Yang Q, Liu L, He GW., Free PMC Article | 05/15/2021 |
| Novel mutations in LTBP2 identified in familial cases of primary congenital glaucoma. | Novel mutations in LTBP2 identified in familial cases of primary congenital glaucoma.
Rauf B, Irum B, Khan SY, Kabir F, Naeem MA, Riazuddin S, Ayyagari R, Riazuddin SA., Free PMC Article | 02/6/2021 |
| Our findings point out LTBP2 as responsible of a systemic phenotype coherent with the community of syndromes related to anomalies in genes involved in the TGFb-pathway. Among these disorders, LTBP2-related systemic disease emerges as a distinct condition with expanding prognostic implications and autosomal recessive inheritance. | LTBP2-related "Marfan-like" phenotype in two Roma/Gypsy subjects with the LTBP2 homozygous p.R299X variant.
Morlino S, Alesi V, Calì F, Lepri FR, Secinaro A, Grammatico P, Novelli A, Drago F, Castori M, Baban A. | 02/15/2020 |
| Data indicate thatlatent transforming growth factor beta binding protein 2 (LTBP2) is a potential prognostic blood biomarker that may reflect the level of differentiation of lung fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis (IPF). | LTBP2 is secreted from lung myofibroblasts and is a potential biomarker for idiopathic pulmonary fibrosis.
Enomoto Y, Matsushima S, Shibata K, Aoshima Y, Yagi H, Meguro S, Kawasaki H, Kosugi I, Fujisawa T, Enomoto N, Inui N, Nakamura Y, Suda T, Iwashita T., Free PMC Article | 08/31/2019 |
| High LTBP2 expression correlates with inferior survival in patients with colorectal cancer and plays a critical role in the progression of colorectal cancer. | High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype.
Huang Y, Wang G, Zhao C, Geng R, Zhang S, Wang W, Chen J, Liu H, Wang X., Free PMC Article | 08/10/2019 |
| Study describes the first case of a microspherophakia phenotype associated with a novel homozygous mutation in the LTBP2 gene in a consanguineous Caucasian family. The insertion of an adenine in exon 36 of the LTBP2 gene (c.5439_5440insA) was associated with pathogenicity. | Next-generation sequencing reveals a new mutation in the LTBP2 gene associated with microspherophakia in a Spanish family.
Alías L, Crespi J, González-Quereda L, Téllez J, Martínez E, Bernal S, Gallano MP., Free PMC Article | 03/2/2019 |
| Results revealed that the expression of LTBP2 was upregulated in gastric cancer (GC) tissues and cell lines. Increased LTBP2 expression was associated with poor overall survival in patients with early-stage [tumor-node-metastasis (TNM) I/II] and late-stage (TNM III/IV) GC. Furthermore, silencing of LTBP2 effectively suppressed the proliferation, migration, invasion and epithelial-mesenchymal transition in GC cells. | LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer.
Wang J, Liang WJ, Min GT, Wang HP, Chen W, Yao N., Free PMC Article | 10/13/2018 |
| effects of both oxidative stress and LTBP2 knockdown on the extracellular matrix and apoptosis may be mediated by TGFbeta and BMP signaling pathway activation | LTBP2 knockdown and oxidative stress affect glaucoma features including TGFβ pathways, ECM genes expression and apoptosis in trabecular meshwork cells.
Suri F, Yazdani S, Elahi E. | 08/25/2018 |
| LTBP2 is a novel biomarker for the diagnosis of pancreatic cancer. | Latent Transforming Growth Factor β Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma.
Wang C, Wang G, Zhang L, Pan J, Wei Y., Free PMC Article | 04/7/2018 |
| Our data suggest that LTBP2 acts as an oncogene in head and neck squamous cell carcinoma development and progression | LTBP2 is a prognostic marker in head and neck squamous cell carcinoma.
Han L, Tang MM, Xu X, Jiang B, Huang J, Feng X, Qiang J., Free PMC Article | 02/3/2018 |
| knockdown of LTBP2 inhibits invasion and tumorigenesis in thyroid carcinoma cells. | Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis in Thyroid Carcinoma Cells.
Wan F, Peng L, Zhu C, Zhang X, Chen F, Liu T., Free PMC Article | 11/4/2017 |
| We identified one nonsense mutation (c.2421G>A, p.W807X) in LTBP2 in eight Indian families. Among the mutations identified W807X in LTBP2 represent novel mutations. | Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma.
Yang Y, Zhang L, Li S, Zhu X, Sundaresan P. | 05/20/2017 |
| LTBP-1 and LTBP-2 are involved in the keratinization of oral epithelium. | Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.
Chiang MS, Yang JR, Liao SC, Hsu CC, Hsu CW, Yuan K. | 12/17/2016 |
| The results showed that no deleterious mutations were found in coding regions of LTBP2 in patients with PCG, suggesting that it is not a causal gene for primary congenital glaucoma in the Han Chinese population. | Screening of the LTBP2 gene in 214 Chinese sporadic CYP1B1-negative patients with primary congenital glaucoma.
Chen X, Chen Y, Fan BJ, Xia M, Wang L, Sun X., Free PMC Article | 11/12/2016 |
| LTBP-2 and FGF-2 are co-localized in fibrotic human keloid and hypertrophic scar. | Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar.
Sideek MA, Teia A, Kopecki Z, Cowin AJ, Gibson MA. | 10/22/2016 |
| LTBP-2 is a potent inhibitor of FGF-2 that may influence FGF-2 bioactivity during wound repair particularly in fibrotic tissues. | LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation.
Menz C, Parsi MK, Adams JR, Sideek MA, Kopecki Z, Cowin AJ, Gibson MA., Free PMC Article | 05/14/2016 |
| LTBP2 was able to reduce phosphorylation of p65 at Serine 536, inhibit nuclear localization of active phosphorylated p65, and impair the p65 DNA-binding ability. This results in a consequential down-regulation of p65-related gene expression. | NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells.
Kan R, Shuen WH, Lung HL, Cheung AK, Dai W, Kwong DL, Ng WT, Lee AW, Yau CC, Ngan RK, Tung SY, Lung ML., Free PMC Article | 02/27/2016 |