| Effect of TGF-beta1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease. | Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease.
Choi Y, Sim S, Lee DH, Lee HR, Ban GY, Shin YS, Kim YK, Park HS., Free PMC Article | 12/11/2021 |
| mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery. | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
Ahmad S, Ytterberg AJ, Thulasingam M, Tholander F, Bergman T, Zubarev R, Wetterholm A, Rinaldo-Matthis A, Haeggström JZ., Free PMC Article | 05/13/2017 |
| Biochemical and structural characterization of LTC4S mutants along with crystal structures of the wild type and mutated enzymes in complex with three product analogs, provide new insights to binding of substrates and product. | Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggström JZ., Free PMC Article | 04/26/2014 |
| The results of our study failed to confirm whether the selected variants in LTC4S gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA. | Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes.
Rosiak M, Postula M, Kaplon-Cieslicka A, Kondracka A, Trzepla E, Zaremba M, Filipiak KJ, Kosior DA, Czlonkowski A, Opolski G, Janicki PK. | 04/12/2014 |
| Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. | Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients.
Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E., Free PMC Article | 03/8/2014 |
| genetic association studies in population of Han Chinese in Eastern China: Data suggest that an SNP in LTC4S (rs730012) is associated with risk of ischemic stroke; carriers of C allele of rs730012 in LTC4S are most susceptible to ischemic stroke. | Genetic variation in members of the leukotrienes biosynthesis pathway confers risk of ischemic stroke in Eastern Han Chinese.
Wang G, Zhang J, Sun H, Cao W, Zhang J, Wang Y, Xiao H. | 05/11/2013 |
| meta-analysis suggested that the -444A/C polymorphism in the LTC4S gene would be a risk factor for asthma in Caucasians and aspirin-tolerant populations | The -444A/C polymorphism in the LTC4S gene and the risk of asthma: a meta-analysis.
Zhang Y, Huang H, Huang J, Xiang Z, Yang M, Tian C, Fan H. | 03/23/2013 |
| A significant association has been found between the -1072G/A (rs3776944) SNP in the LTC4S gene and atopic asthma in the family-based analysis. | Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.
Kumar A, Sharma S, Agrawal A, Ghosh B. | 12/29/2012 |
| The SNPs of ALOX(5)AP and LTC(4)S are associated with asthma. | [Association of leukotriene gene polymorphisms with response to antileukotriene treatment in patients with asthma].
Cai C, Zhou MX, Li YP, Chen CS. | 03/31/2012 |
| investigation of catalytic mechanism of LTC4S: Data suggest that glutathione thiolate anion formation in LTC4S is not rate-limiting for overall reaction of leukotriene C4 production. Thiolate anion is stabilized by Arg104 at all three active sites. | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase.
Rinaldo-Matthis A, Ahmad S, Wetterholm A, Lachmann P, Morgenstern R, Haeggström JZ. | 03/24/2012 |
| Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. | Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Kang MJ, Kwon JW, Kim BJ, Yu J, Choi WA, Shin YJ, Hong SJ. | 08/27/2011 |
| The catalytic architecture of leukotriene C4 synthase with two arginine residues. | The catalytic architecture of leukotriene C4 synthase with two arginine residues.
Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, Yamamoto M, Kanaoka Y, Lam BK, Austen KF, Miyano M., Free PMC Article | 07/2/2011 |
| The increased expression of LTC(4)S, together with the predominant formation of cysteinyl-leukotrienes and effects on MMPs production, suggests a mechanism by which LTs may promote matrix degradation in the AAA wall | Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
Di Gennaro A, Wågsäter D, Mäyränpää MI, Gabrielsen A, Swedenborg J, Hamsten A, Samuelsson B, Eriksson P, Haeggström JZ., Free PMC Article | 02/5/2011 |
| Arginine 104 is a key catalytic residue in leukotriene C4 synthase. | Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
Rinaldo-Matthis A, Wetterholm A, Martinez Molina D, Holm J, Niegowski D, Ohlson E, Nordlund P, Morgenstern R, Haeggström JZ., Free PMC Article | 01/29/2011 |
| In a Southwest Chinese Han population LTC(4)S A(-444)C polymorphism might be a determinant factor in the clinical response of asthma to leukotriene receptor antagonists. | [The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma].
Wu YH, Liu CT, Wang K, Geng YM, Wu YH, Liu CT, Wang K, Geng YM. | 09/13/2010 |
| no association between gene polymorphism and bronchial asthma in a Spanish population | 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
Torres-Galván SM, Cumplido JA, Buset N, Caballero-Hidalgo A, Blanco C, Hernández E, Carrillo T. | 06/14/2010 |
| Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.
Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP., Free PMC Article | 01/20/2010 |
| Leukotriene C4 synthase promoter genotypes influence risk of transient ischemic attack and ischemic stroke, but not risk of ischemic heart disease/coronary atherosclerosis, asthma, or chronic obstructive pulmonary disease. | Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals.
Freiberg JJ, Dahl M, Tybjaerg-Hansen A, Grande P, Nordestgaard BG. | 01/21/2010 |
| LTC(4)S interacts in vitro with both FLAP and 5-LO and that these interactions involve distinct parts of LTC(4)S. | Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.
Strid T, Svartz J, Franck N, Hallin E, Ingelsson B, Söderström M, Hammarström S. | 01/21/2010 |
| The combined study of polymorphisms in genes of the leukotriene pathway could explain the differences observed in the studies reported on polymorphism -444A < C LTC4S individually analysed. | Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma.
Arriba-Méndez S, Sanz C, Isidoro-García M, Pascual M, Avila C, Dávila I, Lorente F. | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
Wang X, Cheng S, Brophy VH, Erlich HA, Mannhalter C, Berger K, Lalouschek W, Browner WS, Shi Y, Ringelstein EB, Kessler C, Luedemann J, Lindpaintner K, Liu L, Ridker PM, Zee RY, Cook NR, RMS Stroke SNP Consortium., Free PMC Article | 03/25/2009 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesAsthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity.
York TP, Vargas-Irwin C, Anderson WH, van den Oord EJ. [The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma].
Wu YH, Liu CT, Wang K, Geng YM, Wu YH, Liu CT, Wang K, Geng YM. | 01/11/2009 |
| Leukotriene C(4) synthase -1072 AA genotype predict increased risk, whereas -444 CC genotype predict decreased risk of ischemic cerebrovascular disease. | Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease.
Freiberg JJ, Tybjaerg-Hansen A, Sillesen H, Jensen GB, Nordestgaard BG. | 01/21/2010 |
| Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations | Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Bevan S, Dichgans M, Wiechmann HE, Gschwendtner A, Meitinger T, Markus HS. | 01/21/2010 |
| Observational study of gene-gene interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) | CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients.
Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS. | 03/13/2008 |