| Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. | Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.
Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P., Free PMC Article | 11/18/2023 |
| Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus. | Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus.
Talotta R., Free PMC Article | 02/16/2023 |
| Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2. | Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2.
Martinez-Molledo M, Nji E, Reyes N. | 06/25/2022 |
| HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19. | HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19.
Garcia-Montojo M, Nath A., Free PMC Article | 08/21/2021 |
| Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cellsdagger. | Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells†.
Lokossou AG, Toudic C, Nguyen PT, Elisseeff X, Vargas A, Rassart É, Lafond J, Leduc L, Bourgault S, Gilbert C, Scorza T, Tolosa J, Barbeau B. | 06/12/2021 |
| There was a difference (p < 0.0001) between trisomy 7 and other patient groups and controls, regarding to the expression of syncytin-1 gene. Numerous mutations in the syncytin-1 and syncytin-2 genes (on the expression sites) were detected, and the mutation rate was higher in the syncytin-1 gene compared to the syncytin-2 gene in the patient and in the control groups (p < 0.001) | Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.
Tug E, Yirmibes Karaoguz M, Nas T. | 04/25/2020 |
| genetic predisposition in ERVFRDE-1 may be associated with an increased risk of preeclampsia. This polymorphism is possibly involved in the regulation of syncytin-2 expression in preeclamptic placenta. | A tag SNP in syncytin-2 3-UTR significantly correlates with the risk of severe preeclampsia.
Hua Y, Wang J, Yuan DL, Qi Y, Tang Z, Zhu X, Jiang SW. | 10/6/2018 |
| N-glycans at residues 133, 312, 332 and 443 of syncytin-2 are required for optimal fusion induction, and that single-nucleotide polymorphism C46R, N118S, T367M, R417H, V483I and T522M can alter the fusogenic function of syncytin-2. | Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.
Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY, Wang H., Free PMC Article | 08/5/2017 |
| Decreased syncytin-2 and MFSD2 proteins in gestational diabetic placentas might cause abnormal syncytiotrophoblast formation and possibly be involved in the pathology | Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.
Soygur B, Sati L, Demir R. | 04/15/2017 |
| ERVWE1, ERVFRDE1 and ERV3 transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia. | Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.
Bolze PA, Patrier S, Cheynet V, Oriol G, Massardier J, Hajri T, Guillotte M, Bossus M, Sanlaville D, Golfier F, Mallet F. | 01/14/2017 |
| These results thereby demonstrate that induced expression of Syncytin-2 is highly dependent on the interaction of bZIP-containing transcription factors to a CRE/AP-1 motif and that this element is important for the regulation of Syncytin-2 expression | A CRE/AP-1-like motif is essential for induced syncytin-2 expression and fusion in human trophoblast-like model.
Toufaily C, Lokossou AG, Vargas A, Rassart É, Barbeau B., Free PMC Article | 02/6/2016 |
| MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion. | MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion.
Toufaily C, Vargas A, Lemire M, Lafond J, Rassart E, Barbeau B. | 06/15/2013 |
| results further highlighted the existence of a correlation between the extent of the decrease in the expression levels of both syncytins 1 and 2 fusogenic proteins and the degree of severity of preeclampsia symptoms | Reduced expression of both syncytin 1 and syncytin 2 correlates with severity of preeclampsia.
Vargas A, Toufaily C, LeBellego F, Rassart É, Lafond J, Barbeau B. | 02/11/2012 |
| Analysis of non-spliced ERVFRDE1 mRNAs and env mRNAs detected efficient splicing of endogenously expressed RNAs in trophoblastic but not in non-placental cells. | Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin.
Trejbalová K, Blazková J, Matousková M, Kucerová D, Pecnová L, Vernerová Z, Herácek J, Hirsch I, Hejnar J., Free PMC Article | 01/21/2012 |
| These results highlight the importance of Syncytin-2 in BeWo and primary human trophoblast cell fusion. | Syncytin-2 plays an important role in the fusion of human trophoblast cells.
Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, Lafond J, Barbeau B. | 01/21/2010 |
| expression decreased in preeclamptic placentas; may function as a second fusogenic protein for placental cell fusion | Functional characterization of the human placental fusogenic membrane protein syncytin 2.
Chen CP, Chen LF, Yang SR, Chen CY, Ko CC, Chang GD, Chen H. | 01/21/2010 |
| Syncytin 2 expression illustrates the abnormal trophoblast differentiation observed in placenta of fetal T21-affected pregnancies. | Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta.
Malassiné A, Frendo JL, Blaise S, Handschuh K, Gerbaud P, Tsatsaris V, Heidmann T, Evain-Brion D., Free PMC Article | 01/21/2010 |
| findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not | Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins.
Mangeney M, Renard M, Schlecht-Louf G, Bouallaga I, Heidmann O, Letzelter C, Richaud A, Ducos B, Heidmann T., Free PMC Article | 01/21/2010 |
| The crystal structure of a central fragment of syncytin 2 "fossil" ectodomain is reported, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses | Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.
Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T. | 01/21/2010 |
| immunolocalized only in the villous trophoblast of the chorionic villi, at the level of cytotrophoblastic cells | Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells.
Malassiné A, Blaise S, Handschuh K, Lalucque H, Dupressoir A, Evain-Brion D, Heidmann T. | 01/21/2010 |