| A glimpse into let-7e roles in human disorders; friend or foe? | A glimpse into let-7e roles in human disorders; friend or foe?
Alshahrani SH, Yuliastanti T, Al-Dolaimy F, Korotkova NL, Rasulova I, Almuala AF, Alsaalamy A, Ali SHJ, Alasheqi MQ, Mustafa YF. | 01/29/2024 |
| Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism. | Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism.
Li Y, Liu YD, Zhou XY, Zhang J, Wu XM, Yang YZ, Chen YX, Zhang XF, Li X, Ma LZ, Wang Z, Chen SL. | 01/29/2022 |
| microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner. | microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner.
Xu S, Zheng L, Kang L, Xu H, Gao L. | 01/1/2022 |
| Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1. | Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
Xiao M, Guo J, Xie L, Yang C, Gong L, Wang Z, Cai J. | 01/23/2021 |
| Studied association of single nucleotide polymorphism (SNP)rs10889677 in the microRNA let-7e and let-7f binding site of interleukin 23 receptor (IL23R) with genetic predisposition to colorectal cancer. | Single nucleotide polymorphism rs10889677 in miRNAs Let-7e and Let-7f binding site of IL23R gene is a strong colorectal cancer determinant: Report and meta-analysis.
Mosallaei M, Simonian M, Esmaeilzadeh E, Bagheri H, Miraghajani M, Salehi AR, Mehrzad V, Salehi R. | 05/2/2020 |
| Levels of miR-146a and miR-155 in monocytes were lower in major depressive disorder patients than in controls and were increased in the former after antidepressant treatment. Multiple linear regression analyses found that let-7e and miR-146a expression before treatment was inversely correlated with severity of depression, whereas miR-155 before treatment was directly correlated with severity of depression. | Aberrant Expression of Intracellular let-7e, miR-146a, and miR-155 Correlates with Severity of Depression in Patients with Major Depressive Disorder and Is Ameliorated after Antidepressant Treatment.
Hung YY, Wu MK, Tsai MC, Huang YL, Kang HY., Free PMC Article | 01/11/2020 |
| both IGF1 and IGF1R mRNA are potential targets for let-7 miRNA family. | IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells.
Li Z, Pan W, Shen Y, Chen Z, Zhang L, Zhang Y, Luo Q, Ying X., Free PMC Article | 11/2/2019 |
| our findings identified the miR-125a~99b~let-7e cluster as a new key intracellular mediator used by the master anti-inflammatory cytokine IL-10 to dampen down the pro-inflammatory TLR pathway and provides a new perspective in the understanding of mechanisms by which the inflammatory response is regulated in phagocytes. | Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster.
Curtale G, Renzi TA, Mirolo M, Drufuca L, Albanese M, De Luca M, Rossato M, Bazzoni F, Locati M., Free PMC Article | 10/19/2019 |
| These findings indicate that the let-7e/EZH2/H3K27me3/NF-kappaB p65 pathway is a novel regulatory axis of TNF-alpha expression. | Let-7e inhibits TNF-α expression by targeting the methyl transferase EZH2 in DENV2-infected THP-1 cells.
Zhang Y, Zhang Q, Gui L, Cai Y, Deng X, Li C, Guo Q, He X, Huang J. | 09/28/2019 |
| Authors report a novel mechanism by which endothelial miR-125a and let-7e-mediated regulation of interleukin-6 (IL-6) signaling can manipulate vasculogenic mimicry (VM) formation of MDA-MB-231 breast cancer cells. We found that endothelial IL-6 levels were significantly higher in response to cisplatin treatment, whereas levels of IL-6 upon cisplatin exposure remained unchanged in MDA-MB-231 breast cancer cells. | Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells.
Park Y, Kim J., Free PMC Article | 07/6/2019 |
| Let-7e plays an important role as tumor suppressor miRNA in colorectal cancer cells probably through inhibition of DCLK1 expression. | Induction of let-7e gene expression attenuates oncogenic phenotype in HCT-116 colorectal cancer cells through targeting of DCLK1 regulation.
Khodadadi Kohlan A, Saidijam M, Amini R, Samadi P, Najafi R. | 06/29/2019 |
| In CSF from Alzheimer s disease (AD) patients, let-7b and let-7e were associated with extracellular vesicles. let-7 family members present in the CSF mediated neurotoxicity in vitro, albeit to a variable extent. Taken together, neurotoxic let-7 miRNAs are differentially and specifically released in AD. | Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease.
Derkow K, Rössling R, Schipke C, Krüger C, Bauer J, Fähling M, Stroux A, Schott E, Ruprecht K, Peters O, Lehnardt S., Free PMC Article | 01/12/2019 |
| The present study revealed let-7e as a pro-inflammatory mediator and a novel regulatory mechanism for the NF-kappaB pathway through ceRNA crosstalk, comprising let-7e and its target IkappaBbeta and the ceRNA lnc-MKI67IP-3. | Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk.
Lin Z, Ge J, Wang Z, Ren J, Wang X, Xiong H, Gao J, Zhang Y, Zhang Q., Free PMC Article | 11/3/2018 |
| NEAT1 promoted oncogenesis by downregulating let-7e expression in glioma stem cells. | Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7e.
Gong W, Zheng J, Liu X, Ma J, Liu Y, Xue Y., Free PMC Article | 02/10/2018 |
| altered expression of miR-33a/let-7e was correlated with ST8SIA1 level, which might contribute to CRC progression | MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
Shan Y, Liu Y, Zhao L, Liu B, Li Y, Jia L. | 11/18/2017 |
| Concentrations of all let-7 miRNAs let-7a, let-7b, let-7c, let-7d, let-7e and let-7g were significantly higher in urine samples obtained from renal cell carcinoma (RCC) patients compared to healthy controls. | Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
Fedorko M, Juracek J, Stanik M, Svoboda M, Poprach A, Buchler T, Pacik D, Dolezel J, Slaby O., Free PMC Article | 09/9/2017 |
| ARID3A was down-regulated by ZEB1 in a miR-99b/let-7e/miR-125a dependent mannerto promotes invasion and metastasis in esophageal squamous cell carcinoma. | ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma.
Ma J, Zhan Y, Xu Z, Li Y, Luo A, Ding F, Cao X, Chen H, Liu Z. | 08/26/2017 |
| In epithelial ovarian cancer, low let-7e leads to activation of BRCA1 and Rad51 expression and subsequent enhancement of DSB repair. | Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair.
Xiao M, Cai J, Cai L, Jia J, Xie L, Zhu Y, Huang B, Jin D, Wang Z., Free PMC Article | 04/22/2017 |
| let-7e may be associated with the pathogenesis of Hashimoto's disease through the regulation of intracellular IL-10 expression. | Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto's disease.
Kagawa T, Watanabe M, Inoue N, Otsu H, Saeki M, Katsumata Y, Takuse Y, Iwatani Y. | 03/4/2017 |
| The study identified Fas ligand (FASLG) as the target of let-7e-5p, and FASLG knockdown increased the migration and tube formation of endothelial progenitor cell. | Downregulation of let-7e-5p contributes to endothelial progenitor cell dysfunction in deep vein thrombosis via targeting FASLG.
Kong L, Du X, Hu N, Li W, Wang W, Wei S, Zhuang H, Li X, Li C. | 10/29/2016 |
| Changes in the plasma level of Let-7e could represent early markers of metabolic dysfunction in children with MetS traits | Micro-RNAs Let7e and 126 in Plasma as Markers of Metabolic Dysfunction in 10 to 12 Years Old Children.
Krause BJ, Carrasco-Wong I, Dominguez A, Arnaiz P, Farías M, Barja S, Mardones F, Casanello P., Free PMC Article | 03/19/2016 |
| Data indicate that knockdown of let-7b or let-7e could recover the growth rate and the invasion of cofilin-1 over-expressing cells. | Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA.
Tsai CH, Lin LT, Wang CY, Chiu YW, Chou YT, Chiu SJ, Wang HE, Liu RS, Wu CY, Chan PC, Yang MH, Chiou SH, Liao MJ, Lee YJ. | 10/3/2015 |
| MIRNlet7e was associated with severe osteoarthritis requiring arthroplasty. | Signature of circulating microRNAs in osteoarthritis.
Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. | 05/16/2015 |
| Lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. | Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer.
Zhu WY, Luo B, An JY, He JY, Chen DD, Xu LY, Huang YY, Liu XG, Le HB, Zhang YK. | 01/10/2015 |
| findings show the rs10889677 variant in the 3'-untranslated region of IL-23R gene displays enhanced levels of both mRNA and production of IL-23R; this can be attributed to loss of binding capacity for the microRNAs Let-7e and Let-7f by the variant allele | Cutting edge: a variant of the IL-23R gene associated with inflammatory bowel disease induces loss of microRNA regulation and enhanced protein production.
Zwiers A, Kraal L, van de Pouw Kraan TC, Wurdinger T, Bouma G, Kraal G. | 03/31/2012 |