| Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. | Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation.
Calcagni' A, Staiano L, Zampelli N, Minopoli N, Herz NJ, Di Tullio G, Huynh T, Monfregola J, Esposito A, Cirillo C, Bajic A, Zahabiyon M, Curnock R, Polishchuk E, Parkitny L, Medina DL, Pastore N, Cullen PJ, Parenti G, De Matteis MA, Grumati P, Ballabio A., Free PMC Article | 07/10/2023 |
| Gimap5 promoted RSV degradation through interaction with M6PR. | Gimap5 promoted RSV degradation through interaction with M6PR.
Dai P, Ruan P, Mao Y, Tang Z, Qiu X, Bajinka O, Tan Y. | 02/11/2023 |
| Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study. | Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.
Usategui-Martín R, Pérez-Castrillón JL, Mansego ML, Lara-Hernández F, Manzano I, Briongos L, Abadía-Otero J, Martín-Vallejo J, García-García AB, Martín-Escudero JC, Chaves FJ. | 12/11/2021 |
| Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs. | Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
Liang XH, Nichols JG, De Hoyos CL, Sun H, Zhang L, Crooke ST., Free PMC Article | 10/9/2021 |
| Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis. | Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis.
Li W, Chung CYL, Wang CC, Chan TF, Leung MBW, Chan OK, Wu L, Appiah K, Chaemsaithong P, Cheng YKY, Poon LCY, Leung TY. | 12/5/2020 |
| The co-localization of M6PR and of GCC2 with ASOs is influenced by the PS modifications, which have been shown to enhance the affinity of ASOs for proteins, suggesting that localization of these proteins to LEs is mediated by ASO-protein interactions. Reduction of M6PR levels also decreased PS-ASO activity in mouse cells and in livers of mice treated subcutaneously with PS-ASO, indicating a conserved mechanism. | Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Liang XH, Sun H, Hsu CW, Nichols JG, Vickers TA, De Hoyos CL, Crooke ST., Free PMC Article | 03/21/2020 |
| Mannose-6-phosphate receptor: a novel regulator of T cell immunity. | Mannose-6-phosphate receptor: a novel regulator of T cell immunity.
Ara A, Ahmed KA, Xiang J., Free PMC Article | 10/5/2019 |
| Results suggest that, in hormone-responsive breast cancer cells, CD-MPR and cathepsin D are distributed together, and that their expression and distribution are influenced by estradiol. These findings strongly support the involvement of the CD-MPR in the pro-enzyme transport in MCF-7 cells, suggesting the participation of this receptor in the procathepsin D secretion previously reported in breast cancer cells. | Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells.
Bannoud N, Carvelli FL, Troncoso M, Sartor T, Vargas-Roig LM, Sosa M., Free PMC Article | 02/9/2019 |
| Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells. | Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells.
Díaz-Salinas MA, Casorla LA, López T, López S, Arias CF., Free PMC Article | 09/15/2018 |
| In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 bearing transport vesicle at TGN elucidating role of Nef during viral pathogenesis. | HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.
Kumar M, Kaur S, Nazir A, Tripathi RK. | 05/13/2017 |
| Results suggest that Rab protein Rab29 is essential for the integrity of the trans-Golgi network (TGN) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR). | A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.
Wang S, Ma Z, Xu X, Wang Z, Sun L, Zhou Y, Lin X, Hong W, Wang T., Free PMC Article | 06/27/2015 |
| These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. | Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.
Stahlschmidt W, Robertson MJ, Robinson PJ, McCluskey A, Haucke V., Free PMC Article | 04/26/2014 |
| Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A. | Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells.
Prabakaran T, Nielsen R, Satchell SC, Mathieson PW, Feldt-Rasmussen U, Sørensen SS, Christensen EI., Free PMC Article | 12/8/2012 |
| Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody | Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.
Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ Jr, Lamazière A, Siegel DL, Wolf C, Scholler N., Free PMC Article | 07/21/2012 |
| mediates in vitro human immunodeficiency virus and sperm cell interaction | In vitro human immunodeficiency virus and sperm cell interaction mediated by the mannose receptor.
Cardona-Maya W, Velilla PA, Montoya CJ, Cadavid Á, Rugeles MT. | 03/31/2012 |
| Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization. | Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31.
Rodriguez-Gabin AG, Yin X, Si Q, Larocca JN., Free PMC Article | 01/21/2010 |
| Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes. | Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.
Pérez-Victoria FJ, Mardones GA, Bonifacino JS., Free PMC Article | 01/21/2010 |
| sortilin and mannose-6-phosphate receptors recycle to the TGN in SNX1-dependent carriers, which we named endosome-to-TGN transport carriers | SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.
Mari M, Bujny MV, Zeuschner D, Geerts WJ, Griffith J, Petersen CM, Cullen PJ, Klumperman J, Geuze HJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesPoor replication of candidate genes for major depressive disorder using genome-wide association data.
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, DeRijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.
Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease.
Kölsch H, Ptok U, Majores M, Schmitz S, Rao ML, Maier W, Heun R. | 03/13/2008 |
| All 5 MPRci-deficient lines resisted infection by cell-free, but not cell-associated, VZV, secreted lysosomal enzymes, and released infectious virions when infected by cell-associated VZV | Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster.
Chen JJ, Zhu Z, Gershon AA, Gershon MD. | 01/21/2010 |
| sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations | Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.
Nair P, Schaub BE, Rohrer J. | 01/21/2010 |
| We conclude that the CI-MPR participates in lysosomal and granular targeting of serglycin and basic proteins such as lysozyme associated with the proteoglycan in hematopoietic cells. | The cation-independent mannose 6-phosphate receptor is involved in lysosomal delivery of serglycin.
Lemansky P, Fester I, Smolenova E, Uhländer C, Hasilik A. | 01/21/2010 |