| Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway. | Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
Que X, Ren L, Yang L, Wang L, Li J, Wu R, Chen Q. | 05/9/2024 |
| Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway. | Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway.
Chen H, Li C, Zhou T, Li X, Duarte MEL, Daubs MD, Buser Z, Brochmann EJ, Wang JC, Murray SS, Jiao L, Tian H. | 07/31/2023 |
| A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis. | A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis.
Gregson CL, Bergen DJM, Leo P, Sessions RB, Wheeler L, Hartley A, Youlten S, Croucher PI, McInerney-Leo AM, Fraser W, Tang JC, Anderson L, Marshall M, Sergot L, Paternoster L, Davey Smith G, AOGC Consortium, Brown MA, Hammond C, Kemp JP, Tobias JH, Duncan EL., Free PMC Article | 09/18/2021 |
| Cyclic AMP appears to promote SMAD1/5/8 pathway activity intracellularly and has the ability to activate canonical SMAD1/5/8 downstream targets. | Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.
Bertoldo MJ, Cheung MY, Sia ZK, Agapiou D, Corley SM, Wilkins MR, Richani D, Harrison CA, Gilchrist RB. | 01/18/2020 |
| The SNPs of the rs6435156 and rs1048829 locus in the BMPR2 gene, the rs121909287 loci in the ACVRL1 gene, and the rs397514716 locus in the SMAD9 gene were associated with a risk of essential hypertension (EH) in Han Chinese. | Association of the gene polymorphisms of BMPR2, ACVRL1, SMAD9 and their interactions with the risk of essential hypertension in the Chinese Han population.
Chen Y, Ye C, Chen J, Lin D, Wang H, Wang S., Free PMC Article | 07/27/2019 |
| Our results exclude a significant role for the SMAD9v90m mutation in juvenile polyposis syndrome | Absence of SMAD9(v90m) mutation in juvenile polyposis syndrome.
Graafmans LDC, Morsink FHM, Offerhaus GJA, Giardiello FM, Brosens LAA. | 10/27/2018 |
| Differential expression of TGF-beta superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation. | Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.
Dexheimer V, Gabler J, Bomans K, Sims T, Omlor G, Richter W., Free PMC Article | 05/5/2018 |
| Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension. | New targets for pulmonary arterial hypertension: going beyond the currently targeted three pathways.
Huertas A, Tu L, Guignabert C. | 03/17/2018 |
| Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. | Smad8/9 Is Regulated Through the BMP Pathway.
Katakawa Y, Funaba M, Murakami M. | 09/16/2017 |
| Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression. | Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas.
Ngeow J, Yu W, Yehia L, Niazi F, Chen J, Tang X, Heald B, Lei J, Romigh T, Tucker-Kellogg L, Lim KH, Song H, Eng C. | 01/2/2016 |
| a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. | Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.
Nicklas D, Saiz L., Free PMC Article | 02/8/2014 |
| ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad8 | Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.
Nishida T, Kubota S, Aoyama E, Takigawa M. | 10/19/2013 |
| TNF activated NF-kappaB pathway and inhibited the phosphorylation of Smad 1/5/8 and BMP-2-induced osteoblastic differentiation in BMMSCs | Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.
Tang Y, Xie H, Chen J, Geng L, Chen H, Li X, Hou Y, Lu L, Shi S, Zeng X, Sun L., Free PMC Article | 07/27/2013 |
| CREBZF, a novel Smad8-binding protein. | CREBZF, a novel Smad8-binding protein.
Lee JH, Lee GT, Kwon SJ, Jeong J, Ha YS, Kim WJ, Kim IY. | 12/8/2012 |
| Data suggest that Smads 1, 5 and 8 as potential prognostic markers and therapeutic targets for mTOR inhibition therapy of prostate cancer. | Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.
Wahdan-Alaswad RS, Bane KL, Song K, Shola DT, Garcia JA, Danielpour D., Free PMC Article | 11/3/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH. | A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.
Shintani M, Yagi H, Nakayama T, Saji T, Matsuoka R. | 01/21/2010 |
| 5-HT transactivates the serine kinase receptor, BMPR 1A, to activate Smads 1/5/8 via Rho and Rho kinase in in bovine and human pulmonary artery smooth muscle cells | Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.
Liu Y, Ren W, Warburton R, Toksoz D, Fanburg BL. | 01/21/2010 |
| increases of p16(INK4a) and p21(WAF1/cip1) expression in response to BMP4 were mediated by the Smad1/5/8 signaling pathway. | BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells.
Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, Pan L, Zhang Y, Lu J, Huang B., Free PMC Article | 01/21/2010 |
| Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC | Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
Lee NY, Ray B, How T, Blobe GC., Free PMC Article | 01/21/2010 |