| ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy. | ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.
Wang YM, Tang H, Tang YJ, Liu J, Yin YF, Tang YL, Feng YG, Gu HF., Free PMC Article | 10/1/2024 |
| Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells. | Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BK(Ca) channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells.
Pissas KP, Gründer S, Tian Y., Free PMC Article | 09/23/2024 |
| Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. | Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury.
Lai K, Pritišanac I, Liu ZQ, Liu HW, Gong LN, Li MX, Lu JF, Qi X, Xu TL, Forman-Kay J, Shi HB, Wang LY, Yin SK., Free PMC Article | 07/31/2024 |
| ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy. | ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy.
Wang Y, Zhang J, Jiang P, Li K, Sun Y, Huang Y. | 07/25/2024 |
| ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA/AP-1 signaling pathway. | ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA/AP-1 signaling pathway.
Liu Y, Wang B, Cheng Y, Fang Y, Hou Y, Mao Y, Wu X, Jiang D, He Y, Jin C. | 06/20/2024 |
| ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction. | ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction.
Wang T, Wang Q, Pan G, Jia G, Li X, Wang C, Zhang L, Zuo C., Free PMC Article | 08/7/2023 |
| ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3beta/Snail pathway driven by TGFbeta/Smad signals. | ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3β/Snail pathway driven by TGFβ/Smad signals.
Zhang Y, Cao N, Gao J, Liang J, Liang Y, Xie Y, Zhou S, Tang X., Free PMC Article | 05/21/2022 |
| Regulation of gliomagenesis and stemness through acid sensor ASIC1a. | Regulation of gliomagenesis and stemness through acid sensor ASIC1a.
King P, Wan J, Guo AA, Guo S, Jiang Y, Liu M., Free PMC Article | 01/29/2022 |
| Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD. | Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.
Han X, Zhang Y, Lee A, Li Z, Gao J, Wu X, Zhao J, Wang H, Chen D, Zou D, Owyang C., Free PMC Article | 01/15/2022 |
| Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury. | Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.
Redd MA, Scheuer SE, Saez NJ, Yoshikawa Y, Chiu HS, Gao L, Hicks M, Villanueva JE, Joshi Y, Chow CY, Cuellar-Partida G, Peart JN, See Hoe LE, Chen X, Sun Y, Suen JY, Hatch RJ, Rollo B, Xia D, Alzubaidi MAH, Maljevic S, Quaife-Ryan GA, Hudson JE, Porrello ER, White MY, Cordwell SJ, Fraser JF, Petrou S, Reichelt ME, Thomas WG, King GF, Macdonald PS, Palpant NJ. | 01/1/2022 |
| Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. | Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.
Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM., Free PMC Article | 10/23/2021 |
| Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression. | Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression.
Nakanishi M, Korechika A, Yamakawa H, Kawabe N, Nakai K, Muragaki Y. | 10/23/2021 |
| Structure and analysis of nanobody binding to the human ASIC1a ion channel. | Structure and analysis of nanobody binding to the human ASIC1a ion channel.
Wu Y, Chen Z, Sigworth FJ, Canessa CM., Free PMC Article | 10/16/2021 |
| Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate. | Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate.
Vullo S, Ambrosio N, Kucera JP, Bignucolo O, Kellenberger S., Free PMC Article | 09/11/2021 |
| ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration. | ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C., Free PMC Article | 08/21/2021 |
| Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors. | Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors.
Ackermann K, Wallner S, Brochhausen C, Schreml S., Free PMC Article | 07/17/2021 |
| Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis. | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis.
Xu Y, Chen F., Free PMC Article | 06/19/2021 |
| Evidence for role of acid-sensing ion channel 1a in chronic rhinosinusitis with nasal polyps. | Evidence for role of acid-sensing ion channel 1a in chronic rhinosinusitis with nasal polyps.
Tang R, Ba G, Li M, Li Z, Ye H, Lin H, Zhang W. | 06/5/2021 |
| Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1. | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L., Free PMC Article | 02/27/2021 |
| ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells. | ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells.
Zhu L, Yin J, Zheng F, Ji L, Yu Y, Liu H. | 02/13/2021 |
| ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca(2+)/Rac1 pathway. | ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca(2+)/Rac1 pathway.
Niu R, Hang X, Feng Y, Zhang Y, Qian X, Song S, Wang C, Tao J, Peng X, Chen F. | 12/12/2020 |
| ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc. | ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc.
Cai F, Hong X, Tang X, Liu NC, Wang F, Zhu L, Xie XH, Xie ZY, Wu XT., Free PMC Article | 09/26/2020 |
| ASIC1a localized in the proximal tubular and contributed to ischemia/reperfusion induced kidney injury. | Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.
Song N, Lu Z, Zhang J, Shi Y, Ning Y, Chen J, Jin S, Shen B, Fang Y, Zou J, Teng J, Chu XP, Shen L, Ding X., Free PMC Article | 07/18/2020 |
| Using electrophysiological measurements of injected Xenopus oocytes, we show that Q276 in beta9 strand works with L415 and N416 to mediate both types of desensitization in ASIC1a, ASIC2a and ASIC3. | A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels.
Wu Y, Chen Z, Canessa CM., Free PMC Article | 02/29/2020 |
| Ligand Docking to the Acidic Pocket of the Proton-Gated Ion Channel Asic1A. | Ligand Docking to the Acidic Pocket of the Proton-Gated Ion Channel Asic1A.
Korkosh VS, Tikhonov DB. | 07/20/2019 |