| A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis. | A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis.
Inoue H, Kanda T, Hayashi G, Munenaga R, Yoshida M, Hasegawa K, Miyagawa T, Kurumada Y, Hasegawa J, Wada T, Horiuchi M, Yoshimatsu Y, Itoh F, Maemoto Y, Arasaki K, Wakana Y, Watabe T, Matsushita H, Harada H, Tagaya M., Free PMC Article | 02/15/2024 |
| Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway. | Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.
Guo Y, Shen M, Dong Q, Méndez-Albelo NM, Huang SX, Sirois CL, Le J, Li M, Jarzembowski ED, Schoeller KA, Stockton ME, Horner VL, Sousa AMM, Gao Y, Birth Defects Research Laboratory, Levine JE, Wang D, Chang Q, Zhao X., Free PMC Article | 07/5/2023 |
| The miR-223-3p/MAP1B axis aggravates TGF-beta-induced proliferation and migration of BPH-1 cells. | The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Wang Z, Zhang Y, Zhao C, Li Y, Hu X, Wu L, Chen M, Tong S. | 04/9/2022 |
| Epilepsy phenotypes associated with MAP1B-related brain malformations. | Epilepsy phenotypes associated with MAP1B-related brain malformations.
Arya R, Spaeth C, Zhang W. | 12/18/2021 |
| Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss. | Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Cui L, Zheng J, Zhao Q, Chen JR, Liu H, Peng G, Wu Y, Chen C, He Q, Shi H, Yin S, Friedman RA, Chen Y, Guan MX., Free PMC Article | 05/29/2021 |
| These neuritic defects result from impaired Nrf2 activity on antioxidant response elements (AREs) localized to a microtubule-associated protein (Map1b) gene enhancer and are rescued by forced expression of Map1b as well as by both Nrf2 overexpression and pharmaceutical activation in Parkinson's disease (PD) neurons | Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.
Czaniecki C, Ryan T, Stykel MG, Drolet J, Heide J, Hallam R, Wood S, Coackley C, Sherriff K, Bailey CDC, Ryan SD., Free PMC Article | 04/4/2020 |
| Knockdown of microtubule-associated protein 1B light chain (MAP 1B-LC1) represses E-cadherin downregulation, vimentin upregulation and actin filament remodeling, decreases cell migration and invasion during TGF-beta1-induced epithelial to mesenchymal transition (EMT) in A549 cells. Heterogeneous nuclear ribonucleoprotein K (hnRNP K) promotes the EMT of lung cancer cells induced by TGF-beta1 through interacting with MAP... | Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells.
Li L, Yan S, Zhang H, Zhang M, Huang G, Chen M., Free PMC Article | 02/22/2020 |
| Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B | Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.
Hatta T, Iemura SI, Ohishi T, Nakayama H, Seimiya H, Yasuda T, Iizuka K, Fukuda M, Takeda J, Natsume T, Horikawa Y., Free PMC Article | 11/2/2019 |
| MAP1B-LC1 links microtubules and Stx17 in fed cells, and starvation causes the dephosphorylation of MAP1B-LC1 at Thr217, allowing Stx17 to dissociate from MAP1B-LC1 and bind to Atg14L. | MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
Arasaki K, Nagashima H, Kurosawa Y, Kimura H, Nishida N, Dohmae N, Yamamoto A, Yanagi S, Wakana Y, Inoue H, Tagaya M., Free PMC Article | 05/18/2019 |
| High MAP1B expression is associated with resistance to mTOR inhibition in glioblastoma. | A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma.
Laks DR, Oses-Prieto JA, Alvarado AG, Nakashima J, Chand S, Azzam DB, Gholkar AA, Sperry J, Ludwig K, Condro MC, Nazarian S, Cardenas A, Shih MYS, Damoiseaux R, France B, Orozco N, Visnyei K, Crisman TJ, Gao F, Torres JZ, Coppola G, Burlingame AL, Kornblum HI., Free PMC Article | 01/19/2019 |
| All of the patients with a microtubule associated protein 1B (MAP1B) variant had a similar brain abnormality, and at least one of the parents who transmitted the variant to their child was also similarly affected. | De novo and inherited private variants in MAP1B in periventricular nodular heterotopia.
Heinzen EL, O'Neill AC, Zhu X, Allen AS, Bahlo M, Chelly J, Chen MH, Dobyns WB, Freytag S, Guerrini R, Leventer RJ, Poduri A, Robertson SP, Walsh CA, Zhang M, Epi4K Consortium, Epilepsy Phenome/Genome Project., Free PMC Article | 06/30/2018 |
| MAP1B heavy chain has a unique binding site for a calcium-binding protein ALG-2. | A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2.
Takahara T, Arai Y, Kono Y, Shibata H, Maki M. | 04/7/2018 |
| These results suggest that a change in the intracellular calcium level plays a role in regulation of the secretory pathway via interaction of ALG-2 with MISSL and MAP1B. | The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins.
Takahara T, Inoue K, Arai Y, Kuwata K, Shibata H, Maki M., Free PMC Article | 10/21/2017 |
| The found of this study suggested that possible roles of MAP1B genes in working memory performance in ADHD patients | MAP1B and NOS1 genes are associated with working memory in youths with attention-deficit/hyperactivity disorder.
Salatino-Oliveira A, Wagner F, Akutagava-Martins GC, Bruxel EM, Genro JP, Zeni C, Kieling C, Polanczyk GV, Rohde LA, Hutz MH. | 02/4/2017 |
| KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. | Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
Liu YF, Sowell SM, Luo Y, Chaubey A, Cameron RS, Kim HG, Srivastava AK., Free PMC Article | 04/16/2016 |
| signal transduction pathways downstream of 5-HT6R are regulated by MAP1B, which might play a role in 5-HT6R-mediated signaling in the brain. | Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1).
Kim SH, Kim DH, Lee KH, Im SK, Hur EM, Chung KC, Rhim H., Free PMC Article | 04/2/2016 |
| The the MAP1B-LC1-mediated regulation most likely involves an internalization of the channels via a dynamin and clathrin-dependent pathway. | The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.
Gandini MA, Sandoval A, Zamponi GW, Felix R., Free PMC Article | 10/3/2015 |
| An interaction between MAP1B LC1 and the ubiquitin-conjugating enzyme UBE2L3. | CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation.
Gandini MA, Henríquez DR, Grimaldo L, Sandoval A, Altier C, Zamponi GW, Felix R, González-Billault C. | 06/27/2015 |
| Localization of MAP1B is altered in amyotrophic lateral sclerosis spinal cords in a transgenic animal model. | Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.
Coyne AN, Siddegowda BB, Estes PS, Johannesmeyer J, Kovalik T, Daniel SG, Pearson A, Bowser R, Zarnescu DC., Free PMC Article | 01/31/2015 |
| Yeast-two-hybrid screening using human LRRK2 kinase domain as bait identified microtubule associated protein 1B (MAP1B) as a LRRK2 interactor. | MAP1B rescues LRRK2 mutant-mediated cytotoxicity.
Chan SL, Chua LL, Angeles DC, Tan EK., Free PMC Article | 10/4/2014 |
| We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression | Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
Lebeau G, Miller LC, Tartas M, McAdam R, Laplante I, Badeaux F, DesGroseillers L, Sossin WS, Lacaille JC. | 08/6/2011 |
| These observations define a new and crucial function of MAP1B that is required for efficient cross-talk between microtubules and the actin cytoskeleton during neuronal polarization. | MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity.
Montenegro-Venegas C, Tortosa E, Rosso S, Peretti D, Bollati F, Bisbal M, Jausoro I, Avila J, Cáceres A, Gonzalez-Billault C., Free PMC Article | 03/19/2011 |
| a new protein involved in the terminal differentiation of odontoblasts | Microtubule-associated protein 1b, a neuronal marker involved in odontoblast differentiation.
Maurin JC, Couble ML, Staquet MJ, Carrouel F, About I, Avila J, Magloire H, Bleicher F. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.
Gregório SP, Sallet PC, Do KA, Lin E, Gattaz WF, Dias-Neto E. | 01/11/2009 |
| MAP1B light chain can interact with the tumor suppressor p53. | Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
Lee SY, Kim JW, Jeong MH, An JH, Jang SM, Song KH, Choi KH. | 01/21/2010 |