| CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation. | CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, Hollande F, Mariadason JM, Cheng HC. | 08/7/2024 |
| After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. | IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.
Radhakrishnan Y, Shen X, Maile LA, Xi G, Clemmons DR., Free PMC Article | 01/7/2012 |
| CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. | Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.
Zagozdzon R, Fu Y, Avraham HK. | 01/21/2010 |
| These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. | Decreased CHK protein levels are associated with Src activation in colon cancer cells.
Zhu S, Bjorge JD, Cheng HC, Fujita DJ. | 01/21/2010 |
| Progesterone increases MATK in mast cells and reducs cell proliferation. | Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.
Belot MP, Abdennebi-Najar L, Gaudin F, Emilie D, Machelon V. | 01/21/2010 |
| Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms | Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.
Zagozdzon R, Bougeret C, Fu Y, Avraham HK. | 01/21/2010 |
| CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase | Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.
Mikkola ET, Bergman M. | 01/21/2010 |
| Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. | Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.
Nakayama Y, Kawana A, Igarashi A, Yamaguchi N. | 01/21/2010 |
| Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. | Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.
Nakayama Y, Yamaguchi N. | 01/21/2010 |
| ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines | Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
Kim S, Zagozdzon R, Meisler A, Baleja JD, Fu Y, Avraham S, Avraham H. | 01/21/2010 |
| This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. | Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner.
Zagozdzon R, Kaminski R, Fu Y, Fu W, Bougeret C, Avraham HK. | 01/21/2010 |
| Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses | Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice.
Lee BC, Avraham S, Imamoto A, Avraham HK., Free PMC Article | 01/21/2010 |
| striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains | Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.
Ayrapetov MK, Nam NH, Ye G, Kumar A, Parang K, Sun G. | 01/21/2010 |
| Loss of CHK expression is associated with human brain tumors | Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors.
Kim SO, Avraham S, Jiang S, Zagozdzon R, Fu Y, Avraham HK. | 01/21/2010 |