| MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma. | MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.
Kang EY, Millstein J, Popovic G, Meagher NS, Bolithon A, Talhouk A, Chiu DS, Anglesio MS, Leung B, Tang K, Lambie N, Pavanello M, Da-Anoy A, Lambrechts D, Loverix L, Olbrecht S, Bisinotto C, Garcia-Donas J, Ruiz-Llorente S, Yagüe-Fernandez M, Edwards RP, Elishaev E, Olawaiye A, Taylor S, Ataseven B, du Bois A, Harter P, Lester J, Høgdall CK, Armasu SM, Huang Y, Vierkant RA, Wang C, Winham SJ, Heublein S, Kommoss FKF, Cramer DW, Sasamoto N, van-Wagensveld L, Lycke M, Mateoiu C, Joseph J, Pike MC, Odunsi K, Tseng CC, Pearce CL, Bilic S, Conrads TP, Hartmann A, Hein A, Jones ME, Leung Y, Beckmann MW, Ruebner M, Schoemaker MJ, Terry KL, El-Bahrawy MA, Coulson P, Etter JL, LaVigne-Mager K, Andress J, Grube M, Fischer A, Neudeck N, Robertson G, Farrell R, Barlow E, Quinn C, Hettiaratchi A, Casablanca Y, Erber R, Stewart CJR, Tan A, Yu Y, Boros J, Brand AH, Harnett PR, Kennedy CJ, Nevins N, Morgan T, Fasching PA, Vergote I, Swerdlow AJ, Candido Dos Reis FJ, Maxwell GL, Neuhausen SL, Barquin-Garcia A, Modugno F, Moysich KB, Crowe PJ, Hirasawa A, Heitz F, Karlan BY, Goode EL, Sinn P, Horlings HM, Høgdall E, Sundfeldt K, Kommoss S, Staebler A, Wu AH, Cohen PA, DeFazio A, Lee CH, Steed H, Le ND, Gayther SA, Lawrenson K, Pharoah PDP, Konecny G, Cook LS, Ramus SJ, Kelemen LE, Köbel M., Free PMC Article | 05/7/2022 |
| MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency. | MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
Knapp KM, Jenkins DE, Sullivan R, Harms FL, von Elsner L, Ockeloen CW, de Munnik S, Bongers EMHF, Murray J, Pachter N, Denecke J, Kutsche K, Bicknell LS., Free PMC Article | 03/12/2022 |
| Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome. | Single-cell chromatin accessibility landscape of human umbilical cord blood in trisomy 18 syndrome.
Qiu X, Yu H, Wu H, Hu Z, Zhou J, Lin H, Xue W, Cai W, Chen J, Yan Q, Dai W, Yang M, Tang D, Dai Y., Free PMC Article | 02/5/2022 |
| Bioinformatics Analysis Reveals MCM3 as an Important Prognostic Marker in Cervical Cancer. | Bioinformatics Analysis Reveals MCM3 as an Important Prognostic Marker in Cervical Cancer.
Ma H, Liu Z, Li H, Guo X, Guo S, Qu P, Wang Y., Free PMC Article | 01/15/2022 |
| The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids. | The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C., Free PMC Article | 10/2/2021 |
| PLK1 promotes proliferation and suppresses apoptosis of renal cell carcinoma cells by phosphorylating MCM3. | PLK1 promotes proliferation and suppresses apoptosis of renal cell carcinoma cells by phosphorylating MCM3.
Gao Z, Man X, Li Z, Bi J, Liu X, Li Z, Li J, Zhang Z, Kong C. | 08/21/2021 |
| MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors. | MCM3 proliferative index is worthier over Ki-67 in the characterization of salivary gland tumors.
Raja R, Shetty DC, Chandrakanta, Juneja S, Tandon A, Gulati N. | 07/24/2021 |
| Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. | Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer.
Zhou H, Xiong Y, Zhang G, Liu Z, Li L, Hou S, Zhou T., Free PMC Article | 04/17/2021 |
| Gene expression profiling revealed MCM3 to be a better marker than Ki67 in prognosis of invasive ductal breast carcinoma patients. | Gene expression profiling revealed MCM3 to be a better marker than Ki67 in prognosis of invasive ductal breast carcinoma patients.
Zhao Y, Wang Y, Zhu F, Zhang J, Ma X, Zhang D. | 02/27/2021 |
| Results show that found DNA replication initiation protein MCM3 was upregulated in hepatocellular carcinoma (HCC) tissues and cells and its expression correlated with poor outcome and radioresistance. MCM3 promoted radioresistance through activating NF-kappaB pathway, strengthening the role of MCM subunits in the tumor progression. These Findings revealed an independent prognostic factor of MCM3 for HCC. | Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway.
Yang Q, Xie B, Tang H, Meng W, Jia C, Zhang X, Zhang Y, Zhang J, Li H, Fu B., Free PMC Article | 12/7/2019 |
| Study characterize the interaction of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target - Nrf2 master transactivator of oxidative stress response genes - may have evolved in evolution to mimic the conserved helix-2-insert motif of MCM3. | Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa.
Tamberg N, Tahk S, Koit S, Kristjuhan K, Kasvandik S, Kristjuhan A, Ilves I., Free PMC Article | 11/2/2019 |
| Data report that MCM3 is a novel target of Pin1 through directly interacting with Pin1 WW domain. Proline-directed phosphorylation of MCM3 at S112 and T722 are crucial for the interaction with Pin1. MCM3 as a subunit of the MCM2-7 heterocomplex is part of the pre-replication complex responsible for replication licensing and is implicated in the formation of the replicative helicase during the replication progression. | Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1.
Schumann M, Malešević M, Hinze E, Mathea S, Meleshin M, Schutkowski M, Haehnel W, Schiene-Fischer C. | 09/28/2019 |
| Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors. | Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.
Aporowicz M, Czopnik P, Kubicka E, Piotrowska A, Dziegiel P, Bolanowski M, Domoslawski P. | 03/16/2019 |
| this study shows that MCM3 is a novel proliferation marker in oral squamous cell carcinoma | MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.
Valverde LF, de Freitas RD, Pereira TA, de Resende MF, Agra IMG, Dos Santos JN, Dos Reis MG, Sales CBS, Gurgel Rocha CA. | 08/25/2018 |
| High MCM3 expression is associated with bone metastasis and advanced human prostate cancer. | Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer.
Stewart PA, Khamis ZI, Zhau HE, Duan P, Li Q, Chung LWK, Sang QA., Free PMC Article | 06/9/2018 |
| the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent. | Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis.
Cheng DD, Zhang HZ, Yuan JQ, Li SJ, Yang QC, Fan CY., Free PMC Article | 03/10/2018 |
| reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR-183. | Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.
Lodrini M, Poschmann G, Schmidt V, Wünschel J, Dreidax D, Witt O, Höfer T, Meyer HE, Stühler K, Eggert A, Deubzer HE. | 11/11/2017 |
| The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents. | Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study.
Zieliński R, Kobos J, Zakrzewska A. | 07/29/2017 |
| These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase. | Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.
Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB., Free PMC Article | 06/3/2017 |
| The aim of this study is to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors. | The evaluation of Ki67, p53, MCM3 and PCNA immunoexpressions at the level of the dental follicle of impacted teeth, dentigerous cysts and keratocystic odontogenic tumors.
Coşarcă AS, Mocan SL, Păcurar M, Fülöp E, Ormenişan A. | 04/8/2017 |
| High MCM-3 expression correlated with Cutaneous T-cell Lymphomas. | Expression of MCM-3 and MCM-7 in Primary Cutaneous T-cell Lymphomas.
Jankowska-Konsur A, Kobierzycki C, Reich A, Grzegrzolka J, Maj J, Dziegiel P. | 02/20/2016 |
| normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1 | Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation.
Han X, Mayca Pozo F, Wisotsky JN, Wang B, Jacobberger JW, Zhang Y., Free PMC Article | 08/8/2015 |
| Results show that in Glioma patients, MCM 2, MCM3 and MCM7 mRNA are up-regulated and correlated with poor outcome. | Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas.
Hua C, Zhao G, Li Y, Bie L., Free PMC Article | 02/28/2015 |
| Of the total, the deregulation of several genes (CDK1, CDK2, CDK4, MCM2, MCM3, MCM4, EIF3a and RPN2) were potentially associated with disease development and progression. | Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.
Lian M, Fang J, Han D, Ma H, Feng L, Wang R, Yang F., Free PMC Article | 02/28/2015 |
| The relatively lower MCM3 protein expression in FVPTC. | MCM3 protein expression in follicular and classical variants of papillary thyroid carcinoma.
Igci YZ, Erkilic S, Igci M, Arslan A. | 10/4/2014 |