| In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene. | In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene.
Kamal MM, Mia MS, Faruque MO, Rabby MG, Islam MN, Talukder MEK, Wani TA, Rahman MA, Hasan MM., Free PMC Article | 05/29/2024 |
| High MCM6 expression promotes proliferation and correlates with poor prognosis in triple-negative breast cancer. | High MCM6 expression promotes proliferation and correlates with poor prognosis in triple-negative breast cancer.
Zhang H, Lin YD, Zhuang MX, Zhu L, Yu Y, Chen XG, Wang QS, Lin MB. | 04/24/2024 |
| Hypoxia Induces Tumor-Derived Exosome SNHG16 to Mediate Nasopharyngeal Carcinoma Progression through the miR-23b-5p/MCM6 Pathway. | Hypoxia Induces Tumor-Derived Exosome SNHG16 to Mediate Nasopharyngeal Carcinoma Progression through the miR-23b-5p/MCM6 Pathway.
Hou W, Xu L, Su T, Wu Y, Liu Y, Wei Y. | 01/26/2024 |
| UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells. | UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
Luo Y, Yang Y, Yang C, Li C, Hu R, Geng W, Kang X, Lin H., Free PMC Article | 09/6/2023 |
| De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues. | De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues.
Smits DJ, Schot R, Popescu CA, Dias KR, Ades L, Briere LC, Sweetser DA, Kushima I, Aleksic B, Khan S, Karageorgou V, Ordonez N, Sleutels FJGT, van der Kaay DCM, Van Mol C, Van Esch H, Bertoli-Avella AM, Roscioli T, Mancini GMS., Free PMC Article | 07/12/2023 |
| MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition. | MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition.
Gao C, Li J, Zeng F, Wang L, Chen K, Chen D, Hong J, Qu C. | 06/30/2023 |
| MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. | MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.
Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W., Free PMC Article | 10/8/2022 |
| A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes. | A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.
Shastri VM, Subramanian V, Schmidt KH., Free PMC Article | 09/11/2021 |
| High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma. | High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma.
Jang NR, Baek J, Ko Y, Song PH, Gu MJ., Free PMC Article | 07/31/2021 |
| Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma. | Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma.
Li X, Ren Z, Xiong C, Geng J, Li Y, Liu C, Ren C, Liu H., Free PMC Article | 05/8/2021 |
| The impact of MCM6 on hepatocellular carcinoma in a Southern Chinese Zhuang population. | The impact of MCM6 on hepatocellular carcinoma in a Southern Chinese Zhuang population.
Jia W, Xie L, Wang X, Zhang Q, Wei B, Li H, Qin S, Chen S, Liu J, Tan Y, Zheng S, Liang X, Yang X. | 02/13/2021 |
| Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome. | Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome.
Almazar AE, Chang JY, Larson JJ, Atkinson EJ, Locke GR, Talley NJ, Saito YA., Free PMC Article | 09/12/2020 |
| GTSE1, together with CDC20, PCNA, and MCM6, may synergistically promote adverse prognosis in hepatocellular carcinoma by activating cell cycle. | GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.
Zheng Y, Shi Y, Yu S, Han Y, Kang K, Xu H, Gu H, Sang X, Chen Y, Wang J., Free PMC Article | 08/13/2020 |
| MCM2, MCM4, and MCM6 labeling seems to outperform Ki67 as tools to assess cellular proliferation in breast cancer. The onset of sustained Ki67 expression occurs only in late G1 phase, while MCM can label all proliferative cells during the active phases of cell cycle | MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.
Issac MSM, Yousef E, Tahir MR, Gaboury LA., Free PMC Article | 04/25/2020 |
| Study have demonstrated that high expression rates of proliferative markers TOP2A and MCM6 in colorectal cancer is linked to a beneficial patient outcome. According to the general opinion, a high expression rate correlates with a poor patient outcome and study was able to refute this assertion. | Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer.
Hendricks A, Gieseler F, Nazzal S, Bräsen JH, Lucius R, Sipos B, Claasen JH, Becker T, Hinz S, Burmeister G, Schafmayer C, Schrader C., Free PMC Article | 09/14/2019 |
| Patients with IDH1 mutation and low MCM6 expression exhibited the longest survival | Overexpression of MCM6 predicts poor survival in patients with glioma.
Cai HQ, Cheng ZJ, Zhang HP, Wang PF, Zhang Y, Hao JJ, Wang MR, Wan JH. | 05/11/2019 |
| Our findings indicate that MCM6 predicts poor prognosis and promotes metastasis in HCC. Postoperative serum MCM6 level could be valuable to detect preclinical early recurrence, indicative of a need for more careful surveillance and aggressive therapeutic intervention. | MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence.
Liu M, Hu Q, Tu M, Wang X, Yang Z, Yang G, Luo R., Free PMC Article | 05/11/2019 |
| Data suggest that MCM4 phosphorylation by CDK2 plays role in DNA replication licensing system MCM4/MCM6/MCM7; this phosphorylation interferes with MCM complex function by lowering stability of MCM complex; MCM4 is highly phosphorylated in S phase. (MCM = minichromosome maintenance complex [hexamer of components 4/6/7]; CDK2 = cyclin-dependent kinase-2) | Function of the amino-terminal region of human MCM4 in helicase activity.
Wang X, Ishimi Y. | 01/12/2019 |
| Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. | Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization.
Smith CE, Coltell O, Sorlí JV, Estruch R, Martínez-González MÁ, Salas-Salvadó J, Fitó M, Arós F, Dashti HS, Lai CQ, Miró L, Serra-Majem L, Gómez-Gracia E, Fiol M, Ros E, Aslibekyan S, Hidalgo B, Neuhouser ML, Di C, Tucker KL, Arnett DK, Ordovás JM, Corella D., Free PMC Article | 06/2/2018 |
| MCM6 is a highly reproducible marker of poor prognosis in endometrial cancer | Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma.
Hotton J, Agopiantz M, Leroux A, Charra-Brunaud C, Marie B, Busby-Venner H, Morel O, Guéant JL, Vignaud JM, Battaglia-Hsu SF, Gauchotte G. | 05/12/2018 |
| genetic association studies in population in Western Europe: Data confirm an SNP in MCM6 (rs4988235) is predictive of milk consumption; lack of association of genetically predicted milk consumption with prevention of osteoporosis, ischemic heart disease, or type 2 diabetes suggests few beneficial effects of milk consumption but is more consistent with milk promoting adiposity/overweight. | Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study.
Yang Q, Lin SL, Au Yeung SL, Kwok MK, Xu L, Leung GM, Schooling CM. | 05/5/2018 |
| MCM2-MCM6 complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells. | Minichromosome Maintenance Complex is Required for Checkpoint Kinase 2 Chromatin Loading and its Phosphorylation to DNA Damage Response in SCC-4 Cells.
Li L, Feng Y, Luo R. | 08/5/2017 |
| This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. | An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.
Tatsumi R, Ishimi Y. | 05/20/2017 |
| knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei. | Knockdown of Minichromosome Maintenance Proteins Inhibits Foci Forming of Mediator of DNA-Damage Checkpoint 1 in Response to DNA Damage in Human Esophageal Squamous Cell Carcinoma TE-1 Cells.
Yu J, Wang R, Wu J, Dang Z, Zhang Q, Li B. | 01/14/2017 |
| Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma | Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.
Vigouroux C, Casse JM, Battaglia-Hsu SF, Brochin L, Luc A, Paris C, Lacomme S, Gueant JL, Vignaud JM, Gauchotte G. | 05/7/2016 |