| RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells. | RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.
Sun Q, Sui Y, Li S, Zhou R, Fu Z, Luo J, Zhao W. | 09/25/2024 |
| Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells. | Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.
Wang J, Amin A, Cheung MH, Shi L, Liang C. | 05/28/2022 |
| Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability. | Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability.
Ravindran E, Gutierrez de Velazco C, Ghazanfar A, Kraemer N, Zaqout S, Waheed A, Hanif M, Mughal S, Prigione A, Li N, Fang X, Hu H, Kaindl AM., Free PMC Article | 04/30/2022 |
| MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway. | MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
Su D. | 03/19/2022 |
| MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency. | MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
Knapp KM, Jenkins DE, Sullivan R, Harms FL, von Elsner L, Ockeloen CW, de Munnik S, Bongers EMHF, Murray J, Pachter N, Denecke J, Kutsche K, Bicknell LS., Free PMC Article | 03/12/2022 |
| miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway. | miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
Zhao M, Wang Y, Jiang C, Wang Q, Mi J, Zhang Y, Zuo L, Geng Z, Song X, Ge S, Li J, Wen H, Wang J, Wang Z, Su F. | 11/22/2021 |
| MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer. | MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
Hsu EC, Shen M, Aslan M, Liu S, Kumar M, Garcia-Marques F, Nguyen HM, Nolley R, Pitteri SJ, Corey E, Brooks JD, Stoyanova T., Free PMC Article | 11/6/2021 |
| The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids. | The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
Rubisz P, Hirnle L, Kobierzycki C., Free PMC Article | 10/2/2021 |
| MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. | MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway.
Yang Y, Ma S, Ye Z, Zhou X. | 05/15/2021 |
| MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas. | MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.
Hallén T, Olsson DS, Hammarstrand C, Örndal C, Engvall A, Ragnarsson O, Skoglund T, Johannsson G. | 03/20/2021 |
| In this study, we demonstrated for the first time that MCM2 among MCM2-7 except for MCM5 is specifically degraded, and that MCM2 and MCM7 are localized in the cytoplasm in senescent cells. To examine the relationship between the cytoplasmic localization of MCM proteins and cell cycle phase, the distribution of DNA content of cells showing cytoplasmic localization of MCM2 and MCM7 was examined. | Changes in MCM2-7 proteins at senescence.
Suzuki Y, Yamaguchi Y, Hanada H, Ishimi Y. | 12/28/2019 |
| Our study confirms that MCM7 is a valuable marker for assessing the progression of pancreatic neuroendocrine tumors, especially in patients with early stage disease and without distant metastasis. | High minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery.
Ban X, Yan J, Yu S, Lu Z, Chang X, Jia C, Gao C, Shao H, Wu Y, Mao X, Zhang Y, Li Y, Chen J. | 11/30/2019 |
| Depletion of a second MCM (MCM7), which functions in complex with MCM2 during its canonical functions, reveals an overlapping cilia-deficiency phenotype likely unconnected to replication, although MCM7 appears to regulate a distinct subset of genes and pathways. Our data suggests that MCM2 and 7 exert a role in ciliogenesis in post-mitotic tissues. | Resting cells rely on the DNA helicase component MCM2 to build cilia.
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M., Free PMC Article | 08/24/2019 |
| Here, the authors show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2-7 and the kinase DDK. Cohesin and its loader SCC2/4 (NIPBL/MAU2 in humans) associate with DDK and phosphorylated MCM2-7. | MCM2-7-dependent cohesin loading during S phase promotes sister-chromatid cohesion.
Zheng G, Kanchwala M, Xing C, Yu H., Free PMC Article | 06/8/2019 |
| Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors. | Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.
Aporowicz M, Czopnik P, Kubicka E, Piotrowska A, Dziegiel P, Bolanowski M, Domoslawski P. | 03/16/2019 |
| Our results indicate that MCM7 may exert certain functions on spindle formation to prevent cytokinesis during early mitosis by regulating CDK1 activity. | Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity.
Zheng D, Ye S, Wang X, Zhang Y, Yan D, Cai X, Gao W, Shan H, Gao Y, Chen J, Hu Z, Li H, Li J., Free PMC Article | 12/22/2018 |
| MCM7 is helpful for us to make differential diagnosis in pathological grade, MCM7 combination of Ki67 may serve as more sensitive proliferation markers for evaluation of gastric carcinoma and precancerous lesions | The Expression of MCM7 is a Useful Biomarker in the Early Diagnostic of Gastric Cancer.
Yang JY, Li D, Zhang Y, Guan BX, Gao P, Zhou XC, Zhou CJ. | 09/1/2018 |
| CDT1, MCM7, and NUDT1 were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone. | Five Novel Oncogenic Signatures Could Be Utilized as AFP-Related Diagnostic Biomarkers for Hepatocellular Carcinoma Based on Next-Generation Sequencing.
Yu Z, Wang R, Chen F, Wang J, Huang X. | 05/26/2018 |
| High expression of MCM-7 was reduced in BVP-treated cancer cells. | Breviscapine (BVP) inhibits prostate cancer progression through damaging DNA by minichromosome maintenance protein-7 (MCM-7) modulation.
Guan YB, Yang DR, Nong SJ, Ni J, Hu CH, Li J, Zhu J, Shan YX. | 04/28/2018 |
| Data indicate that RACK1 increases interactions between Akt and MCM7 and promotes Akt-dependent MCM7 phosphorylation, which in turn increases MCM7 binding to chromatin and miniature chromosome maintenance (MCM) complex formation. | RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex.
Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W, Han Y., Free PMC Article | 04/14/2018 |
| our findings suggested that MCM7 promoted tumor cell proliferation, colony formation and migration of ESCC cells via activating AKT1/mTOR signaling pathway | MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.
Qiu YT, Wang WJ, Zhang B, Mei LL, Shi ZZ. | 03/3/2018 |
| Results proved that MCM7 proliferative index is a better method for identifying patients with risk of recurrence in patients surgically resected for meningiomas compared with the traditional methods used in the current clinical practice. | MCM7 expression is a promising predictor of recurrence in patients surgically resected for meningiomas.
Winther TL, Torp SH. | 12/16/2017 |
| MCM7-cyclin D1 pathway may participate in cancer progression. | MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinoma.
Qu K, Wang Z, Fan H, Li J, Liu J, Li P, Liang Z, An H, Jiang Y, Lin Q, Dong X, Liu P, Liu C., Free PMC Article | 11/4/2017 |
| The MCM7 directly binds to the centrosomal linker protein Cep68 in vitro and complexes with Cep68 and VHL in vivo. | Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.
Kong L, Yin H, Yuan L. | 09/23/2017 |
| The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer. | Amplified 7q21-22 gene MCM7 and its intronic miR-25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features.
Tamilzhalagan S, Rathinam D, Ganesan K. | 09/9/2017 |