| Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance. | Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.
Ran M, Zhou Y, Guo Y, Huang D, Zhang SL, Tam KY. | 10/6/2023 |
| Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1? | Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?
Subbiah V, Gan B. | 09/10/2022 |
| Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species. | Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.
Lee D, Zhang MS, Tsang FH, Bao MH, Xu IM, Lai RK, Chiu DK, Tse AP, Law CT, Chan CY, Yuen VW, Chui NN, Ng IO, Wong CM, Wong CC. | 01/8/2022 |
| miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1. | miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1.
Jiang Z, Cui H, Zeng S, Li L. | 05/15/2021 |
| Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas. | Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H., Free PMC Article | 02/27/2021 |
| In which ME1 transcripts are upregulated. | Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C, Li Y. | 03/28/2020 |
| A small molecule inhibitor of ME1 suppressed growth of human CRC cells in vitro, but had little effect on normal rat intestinal epithelial cells. Targeting of ME1 may add to the armentarium of therapies for cancers of the gastrointestinal tract. | Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min/+) mice.
Fernandes LM, Al-Dwairi A, Simmen RCM, Marji M, Brown DM, Jewell SW, Simmen FA., Free PMC Article | 11/2/2019 |
| ME1 promotes basal-like breast cancer progression and associates with poor prognosis | ME1 promotes basal-like breast cancer progression and associates with poor prognosis.
Liao R, Ren G, Liu H, Chen X, Cao Q, Wu X, Li J, Dong C., Free PMC Article | 11/2/2019 |
| results shed light on crucial roles of ME1-mediated production of NADPH in gastric cancer growth and metastasis | ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis.
Lu YX, Ju HQ, Liu ZX, Chen DL, Wang Y, Zhao Q, Wu QN, Zeng ZL, Qiu HB, Hu PS, Wang ZQ, Zhang DS, Wang F, Xu RH. | 07/6/2019 |
| Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues. | Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression.
Liu M, Chen Y, Huang B, Mao S, Cai K, Wang L, Yao X., Free PMC Article | 10/13/2018 |
| Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs). | Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H., Free PMC Article | 06/23/2018 |
| The critical roles of miR-30a and ME1 in the development of KRAS-mutant colorectal cancer indicate therapy potentials for this subtype of cancer. | MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1.
Shen H, Xing C, Cui K, Li Y, Zhang J, Du R, Zhang X, Li Y., Free PMC Article | 03/31/2018 |
| these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer. | Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions.
Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P, Du W., Free PMC Article | 10/21/2017 |
| ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. | Expression of Malic Enzymes in Sebaceous Lesions.
Su TF, Gao HW. | 01/28/2017 |
| ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance. | Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer.
Chakrabarti G., Free PMC Article | 03/26/2016 |
| ME1 overexpression associates with unfavorable prognoses in patients with HCC, suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma. | Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma.
Wen D, Liu D, Tang J, Dong L, Liu Y, Tao Z, Wan J, Gao D, Wang L, Sun H, Fan J, Wu W. | 11/21/2015 |
| essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells | Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines.
Zheng FJ, Ye HB, Wu MS, Lian YF, Qian CN, Zeng YX., Free PMC Article | 08/31/2013 |
| the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME | Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme.
Murugan S, Hung HC., Free PMC Article | 06/22/2013 |
| p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells | Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.
Jiang P, Du W, Mancuso A, Wellen KE, Yang X., Free PMC Article | 02/16/2013 |
| cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption | Malic enzyme gene polymorphism is associated with responsiveness in circulating parathyroid hormone after long-term calcium supplementation.
Chailurkit L, Chanprasertyothin S, Charoenkiatkul S, Krisnamara N, Rajatanavin R, Ongphiphadhanakul B. | 07/7/2012 |
| ME1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers | Functional roles of the tetramer organization of malic enzyme.
Hsieh JY, Chen SH, Hung HC., Free PMC Article | 01/21/2010 |
| although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets | Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ., Free PMC Article | 01/21/2010 |
| A series of R98/D102 mutants examined the possible interactions between Arg98 and Asp102 using double-mutant cycle analysis. Kinetic analysis revealed that the catalytic efficiency of was severely affected by mutating both Arg98 and Asp102 residues. | Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme.
Hsieh JY, Su KL, Ho PT, Hung HC. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |