| A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. | A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.
Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK., | 10/30/2024 |
| Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling. | Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling.
Wu S, Xue S, Tang Y, Zhao W, Zheng M, Cheng Z, Hu X, Sun J, Ren J., Free PMC Article | 10/25/2024 |
| MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer. | MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer.
Kuo SH, Wei MF, Lee YH, Lin JC, Yang WC, Yang SY, Huang CS. | 11/20/2023 |
| Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. | Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B, SGBCC Investigators, Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J., Free PMC Article | 10/19/2023 |
| Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer. | Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.
Fatemi N, Tu SJ, Chung CC, Moghadam PK, Mojarad EN, Sadeghi A, Totonchi M, Aghdaei HA, Chang JG. | 09/18/2023 |
| MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta-analysis. | MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta-analysis.
Aziz MA, Islam MS., Free PMC Article | 02/11/2023 |
| Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study. | Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study.
Kwak JH, Eun CS, Han DS, Kim YS, Song KS, Choi BY, Kim HJ., Free PMC Article | 12/24/2022 |
| Pathogenic Variants in MAP3K1 Cause 46,XY Gonadal Dysgenesis: A Review. | Pathogenic Variants in MAP3K1 Cause 46,XY Gonadal Dysgenesis: A Review.
Ostrer H. | 11/12/2022 |
| Identification of a novel MAP3K1 variant in a family with 46, XY DSD and partial growth hormone deficiency. | Identification of a novel MAP3K1 variant in a family with 46, XY DSD and partial growth hormone deficiency.
Cheng Y, Xu C, Yang J, Zhou X, Chen N., Free PMC Article | 10/1/2022 |
| MicroRNA-203a-3p may prevent the development of thyroid papillary carcinoma via repressing MAP3K1 and activating autophagy. | MicroRNA-203a-3p may prevent the development of thyroid papillary carcinoma via repressing MAP3K1 and activating autophagy.
Dai L, Zhang W, Wu X, Zhou S., Free PMC Article | 06/11/2022 |
| LncRNA KCNQ1OT1 activated by c-Myc promotes cell proliferation via interacting with FUS to stabilize MAP3K1 in acute promyelocytic leukemia. | LncRNA KCNQ1OT1 activated by c-Myc promotes cell proliferation via interacting with FUS to stabilize MAP3K1 in acute promyelocytic leukemia.
Tang D, Luo Y, Jiang Y, Hu P, Peng H, Wu S, Zhang G, Wang Y., Free PMC Article | 01/29/2022 |
| RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA. | RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
Zhang M, Zhao S, Tan C, Gu Y, He X, Du X, Li D, Wei P., Free PMC Article | 01/1/2022 |
| [Gonadal dysgenesis 46,XY DSD associated with variants in the MAP3K1 gene]. | [Gonadal dysgenesis 46,XY DSD associated with variants in the MAP3K1 gene].
Kalinchenko NY, Tiulpakov AN. | 10/30/2021 |
| MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival. | MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.
Bacher S, Stekman H, Farah CM, Karger A, Kracht M, Schmitz ML., Free PMC Article | 10/16/2021 |
| Characteristics and possible mechanisms of 46, XY differences in sex development caused by novel compound variants in NR5A1 and MAP3K1. | Characteristics and possible mechanisms of 46, XY differences in sex development caused by novel compound variants in NR5A1 and MAP3K1.
Cheng Y, Chen J, Zhou X, Yang J, Ji Y, Xu C., Free PMC Article | 07/17/2021 |
| Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma. | Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma.
Wang J, Zuo J, Wahafu A, Wang MD, Li RC, Xie WF., Free PMC Article | 07/3/2021 |
| A novel missense heterozygous mutation in MAP3K1 gene causes 46, XY disorder of sex development: case report and literature review. | A novel missense heterozygous mutation in MAP3K1 gene causes 46, XY disorder of sex development: case report and literature review.
Al Shamsi A, Al Hassani N, Hamchou M, Almazrouei R, Mhanni A., Free PMC Article | 06/12/2021 |
| Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development. | Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development.
Igarashi M, Masunaga Y, Hasegawa Y, Kinjo K, Miyado M, Saitsu H, Kato-Fukui Y, Horikawa R, Okubo Y, Ogata T, Fukami M., Free PMC Article | 03/13/2021 |
| A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers. | A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.
Filipčík P, Latham SL, Cadell AL, Day CL, Croucher DR, Mace PD., Free PMC Article | 10/24/2020 |
| miR-101 expression and RISC binding is increased after cyclosporine treatment in kidney cells; targets and reduces expression of MAP3K1 in vitro | Defining a microRNA-mRNA interaction map for calcineurin inhibitor induced nephrotoxicity.
Benway CJ, Iacomini J. | 03/10/2020 |
| These mutations increase the binding of the RHOA, MAP3K4 and FRAT1 proteins and generally decrease the binding of RAC1. Thus, pathologies in MAP3K1 disrupt the balance between the pro-kinase activities of the RHOA and MAP3K4 binding partners and the inhibitory activity of RAC1. | Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.
Chamberlin A, Huether R, Machado AZ, Groden M, Liu HM, Upadhyay K, O V, Gomes NL, Lerario AM, Nishi MY, Costa EMF, Mendonca B, Domenice S, Velasco J, Loke J, Ostrer H. | 02/8/2020 |
| Of note, the enforced expression of MEKK1 or the exposure of medulloblastoma cells to the MEKK1 activator, Nocodazole, resulted in a marked inhibitory effect on GLI1 activity and tumor cell proliferation and viability. Taken together, the results of this study shed light on a novel regulatory mechanism of HH signaling, with potentially relevant implications in cancer therapy. | Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.
Antonucci L, Di Magno L, D'Amico D, Manni S, Serrao SM, Di Pastena F, Bordone R, Yurtsever ZN, Caimano M, Petroni M, Giorgi A, Schininà ME, Yates Iii JR, Di Marcotullio L, De Smaele E, Checquolo S, Capalbo C, Agostinelli E, Maroder M, Coni S, Canettieri G., Free PMC Article | 04/6/2019 |
| CXCL12 activates the MEKK1/JNK signaling pathway, which in turn initiates SMAD3 phosphorylation, its translocation to nuclei, and recruitment of SMAD3 to the CTGF promoter, which ultimately induces CTGF expression in human lung fibroblasts. | MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts.
Lin CH, Shih CH, Lin YC, Yang YL, Chen BC., Free PMC Article | 08/18/2018 |
| Through a stratification analysis, 5q11.2/MAP3K1 (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B. | Association Study Confirmed Three Breast Cancer-Specific Molecular Subtype-Associated Susceptibility Loci in Chinese Han Women.
Xu Y, Chen M, Liu C, Zhang X, Li W, Cheng H, Zhu J, Zhang M, Chen Z, Zhang B., Free PMC Article | 04/28/2018 |
| findings show a robust association between the variant allele of rs832582 (MAP3K1906Val) and decreased VFDs in patients with ARDS and suggest that this variant may predispose individuals to a greater inflammatory response. | Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.
Morrell ED, O'Mahony DS, Glavan BJ, Harju-Baker S, Nguyen C, Gunderson S, Abrahamson A, Radella F 2nd, Rona G, Black RA, Wurfel MM., Free PMC Article | 02/24/2018 |