| Low expression of MEOX2 is associated with poor survival in patients with breast cancer. | Low expression of MEOX2 is associated with poor survival in patients with breast cancer.
Wang H, Tang Y, Wang M, Zhao J, Ding C, Yang X, Han P, Liu P. | 02/4/2023 |
| MEOX2 homeobox gene promotes growth of malignant gliomas. | MEOX2 homeobox gene promotes growth of malignant gliomas.
Schönrock A, Heinzelmann E, Steffl B, Demirdizen E, Narayanan A, Krunic D, Bähr M, Park JW, Schmidt C, Özduman K, Pamir MN, Wick W, Bestvater F, Weichenhan D, Plass C, Taranda J, Mall M, Turcan Ş., Free PMC Article | 11/5/2022 |
| MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma. | MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma.
Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, Wu G, Zhou H, Xiao Z, Chen Y, Zhang T, Lan Q., Free PMC Article | 07/23/2022 |
| Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways. | Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways.
Cai Y, Liu Y, Sun Y, Ren Y. | 03/5/2022 |
| Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis. | Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis.
Huang Y, Liang B, Chen X., Free PMC Article | 01/22/2022 |
| Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies. | Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies.
Yu R, Zhang J, Zhuo Y, Hong X, Ye J, Tang S, Zhang Y., Free PMC Article | 01/8/2022 |
| Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX). | Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX).
Wang W, Hong G, Wang S, Gao W, Wang P., Free PMC Article | 11/22/2021 |
| Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion. | Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion.
Kim TY, Park JK, Prasad Aryal Y, Lee ES, Neupane S, Sung S, Pokharel E, Yeon CY, Kim JY, Jung JK, Yamamoto H, An CH, Lee Y, Sohn WJ, Jang IH, An SY, Kim JY., Free PMC Article | 03/6/2021 |
| our results may be the first to provide insight into the clinical significance of MEOX2 in gliomas | Prognostic significance of MEOX2 in gliomas.
Tachon G, Masliantsev K, Rivet P, Petropoulos C, Godet J, Milin S, Wager M, Guichet PO, Karayan-Tapon L. | 04/25/2020 |
| Over-expression of MEOX2 in laryngeal cancer cells inhibited cell viability and promoted apoptosis, via regulating apoptosis and PI3K/Akt pathway related factors. | Over-expression of MEOX2 promotes apoptosis through inhibiting the PI3K/Akt pathway in laryngeal cancer cells.
Tian L, Tao ZZ, Ye HP, Li GY, Zhan ZF, Tuo HW. | 07/6/2019 |
| MEOX2 polymorphism is associated with nonsyndromic cleft palate. | Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population.
Tran DL, Imura H, Mori A, Suzuki S, Niimi T, Ono M, Sakuma C, Nakahara S, Nguyen TTH, Pham PT, Hoang V, Tran VTT, Nguyen MD, Natsume N. | 10/20/2018 |
| MEOX2 may serve a protective role, enabling increased vessel formation despite exposure to a diabetes mellitus intrauterine environment. | Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus.
Gohn CR, Blue EK, Sheehan BM, Varberg KM, Haneline LS., Free PMC Article | 05/20/2017 |
| 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. | Activation of Transcription Factor GAX and Concomitant Downregulation of IL-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds.
Lin S, Mequanint K. | 06/4/2016 |
| MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients | Overexpression of MEOX2 and TWIST1 is associated with H3K27me3 levels and determines lung cancer chemoresistance and prognosis.
Ávila-Moreno F, Armas-López L, Álvarez-Moran AM, López-Bujanda Z, Ortiz-Quintero B, Hidalgo-Miranda A, Urrea-Ramírez F, Rivera-Rosales RM, Vázquez-Manríquez E, Peña-Mirabal E, Morales-Gómez J, Vázquez-Minero JC, Téllez-Becerra JL, Ramírez-Mendoza R, Ávalos-Bracho A, de Alba EG, Vázquez-Santillán K, Maldonado-Lagunas V, Santillán-Doherty P, Piña-Sánchez P, Zúñiga-Ramos J., Free PMC Article | 01/16/2016 |
| Genetic variation in MEOX2, but not TCF15, is a strong predictor of CHD. Further experimental studies should elucidate the underlying molecular mechanisms. | Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.
Yang WY, Petit T, Thijs L, Zhang ZY, Jacobs L, Hara A, Wei FF, Salvi E, Citterio L, Delli Carpini S, Gu YM, Knez J, Cauwenberghs N, Barcella M, Barlassina C, Manunta P, Coppiello G, Aranguren XL, Kuznetsova T, Cusi D, Verhamme P, Luttun A, Staessen JA., Free PMC Article | 01/16/2016 |
| Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium. | Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.
Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A. | 05/9/2015 |
| downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients | Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma.
Zhou P, Chen Z, Chang RM, Jiang W, Wu LL, Wang ZM. | 07/20/2013 |
| MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner. | Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
Douville JM, Cheung DY, Herbert KL, Moffatt T, Wigle JT., Free PMC Article | 04/28/2012 |
| Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. | MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta.
Chen Y, Rabson AB, Gorski DH., Free PMC Article | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Loss of MEOX2 gene is associated with Wilms tumor. | Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.
Ohshima J, Haruta M, Arai Y, Kasai F, Fujiwara Y, Ariga T, Okita H, Fukuzawa M, Hata J, Horie H, Kaneko Y. | 01/21/2010 |
| MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter | A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
Irelan JT, Gutierrez Del Arroyo A, Gutierrez A, Peters G, Quon KC, Miraglia L, Chanda SK., Free PMC Article | 01/21/2010 |
| ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. | Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Valcourt U, Thuault S, Pardali K, Heldin CH, Moustakas A., Free PMC Article | 01/21/2010 |
| miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 | Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5.
Chen Y, Gorski DH., Free PMC Article | 01/21/2010 |
| MEOX2 binding to RNF10 protein, human, was characterized. | Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT. | 01/21/2010 |