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    SCGB2A1 secretoglobin family 2A member 1 [ Homo sapiens (human) ]

    Gene ID: 4246, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients.

    Detection of gene expression in sentinel lymph node of primary breast cancer patients.
    Soleimani S, Alizadeh Shargh S, Keramatinia A, Mehrvar N, Mansouri N, Doosti A, Mortazavi-Tabatabaei SA, Hashemi M, Movafagh A.

    09/22/2018
    novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples

    The Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast Cancer in Surgical and Cytology Specimens of Metastatic and Matched Primary Tumors.
    Sangoi AR, Shrestha B, Yang G, Mego O, Beck AH., Free PMC Article

    12/17/2016
    The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome.

    GATA-binding protein 3, gross cystic disease fluid protein-15 and mammaglobin have distinct prognostic implications in different invasive breast carcinoma subgroups.
    Ni YB, Tsang JY, Chan SK, Tse GM.

    03/19/2016
    Results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients.

    The clinical utility of circulating tumor cells in breast cancer patients: detection by a quantitative assay of h-MAM gene expression.
    Cheng M, Chen Y, Zou D, Shen G, Bian G, Shen G, Hu S.

    07/4/2015
    Results indicated that SCGB2A1 represented a novel, prognostic factor for colorectal cancer, and its expression correlated with chemoresistance, radioresistance and cancer cell stemness.

    SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.
    Munakata K, Uemura M, Takemasa I, Ozaki M, Konno M, Nishimura J, Hata T, Mizushima T, Haraguchi N, Noura S, Ikenaga M, Okamura S, Fukunaga M, Murata K, Yamamoto H, Doki Y, Mori M.

    11/22/2014
    The data indicate that MGB1, MGB2 and LIPB mRNAs are expressed at low levels in human tissues but basal expression is upregulated in ovarian cancer.

    Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.
    Fischer K, von Brünneck AC, Hornung D, Denkert C, Ufer C, Schiebel H, Kuhn H, Borchert A.

    05/31/2014
    SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers.

    Mammaglobin B (SCGB2A1) is a novel tumour antigen highly differentially expressed in all major histological types of ovarian cancer: implications for ovarian cancer immunotherapy.
    Bellone S, Tassi R, Betti M, English D, Cocco E, Gasparrini S, Bortolomai I, Black JD, Todeschini P, Romani C, Ravaggi A, Bignotti E, Bandiera E, Zanotti L, Pecorelli S, Ardighieri L, Falchetti M, Donzelli C, Siegel ER, Azodi M, Silasi DA, Ratner E, Schwartz PE, Rutherford TJ, Santin AD., Free PMC Article

    10/19/2013
    MGB has the highest expression in HER2-overexpressing breast cancers and may be a potentially useful marker for this subtype.

    Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas.
    Luo MH, Huang YH, Ni YB, Tsang JY, Chan SK, Shao MM, Tse GM.

    08/31/2013
    Data show that plasma mammaglobin mRNA alone or in combination with CA15.3 (CD227) may be used as a valuable noninvasive approach for the diagnosis and the detection of metastasis in breast cancer at the time of diagnosis.

    Plasma mammaglobin messenger RNA in breast cancer patients as an addition to serum tumor.
    El-Attar NI, Gaefar HA.

    05/3/2010
    MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome

    Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence.
    Tassi RA, Calza S, Ravaggi A, Bignotti E, Odicino FE, Tognon G, Donzelli C, Falchetti M, Rossi E, Todeschini P, Romani C, Bandiera E, Zanotti L, Pecorelli S, Santin AD., Free PMC Article

    01/21/2010
    MGB-2 is highly expressed in endometrioid endometrial cancer [EEC], particularly in well- and moderately differentiated tumors, and may represent a novel molecular marker for EEC

    Mammaglobin B expression in human endometrial cancer.
    Tassi RA, Bignotti E, Falchetti M, Calza S, Ravaggi A, Rossi E, Martinelli F, Bandiera E, Pecorelli S, Santin AD.

    01/21/2010
    Expression levels of mammaglobins A and B in nasal polyps are not different between patients with and without AR

    Expression of mammaglobins A and B in nasal polyps is similar in patients with and without allergic rhinitis.
    Chusakul S, Phannaso C, Tongkobpetch S, Aeumjaturapat S, Poovorawan Y, Suphapeetiporn K, Shotelersuk V.

    01/21/2010
    Results indicate that mammaglobin, as measured by the ELISA, holds significant promise for breast cancer screening with the realistic potential to impact management of this disease.

    Identification of mammaglobin as a novel serum marker for breast cancer.
    Bernstein JL, Godbold JH, Raptis G, Watson MA, Levinson B, Aaronson SA, Fleming TP.

    01/21/2010
    MGB2 markers may be useful for identifying micrometastases in sentinel lymph nodes of breast cancer patients.

    RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.
    Ouellette RJ, Richard D, Maïcas E.

    01/21/2010
    The mammaglobin/lipophilin B complex is a promising diagnostic marker for breast cancer.

    Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.
    Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS.

    01/21/2010
    SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors.

    Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors.
    Xiao F, Mirwald A, Papaioannou M, Baniahmad A, Klug J.

    01/21/2010
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