| Detection of HPP1 mfcDNA can be used as a prognostic marker and an early marker for response (as early as 3-4 weeks after start of treatment compared with radiological staging after 12 or 24 weeks) to identify patients who will likely benefit from a combination chemotherapy with bevacizumab | Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer.
Herbst A, Vdovin N, Gacesa S, Ofner A, Philipp A, Nagel D, Holdt LM, Op den Winkel M, Heinemann V, Stieber P, Graeven U, Reinacher-Schick A, Arnold D, Ricard I, Mansmann U, Hegewisch-Becker S, Kolligs FT. | 09/22/2024 |
| HPP1 tumor suppressive effects are mediated through JAK-STAT-Interferon pathways. | The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways.
Hernandez JM, Elahi A, Clark W, Humphries LA, Wang J, Achille A, Seto E, Shibata D., Free PMC Article | 09/22/2024 |
| We were able to provide evidence that methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker | Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer.
Philipp AB, Nagel D, Stieber P, Lamerz R, Thalhammer I, Herbst A, Kolligs FT., Free PMC Article | 09/22/2024 |
| Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia. | Stem cell factor and cKIT modulate endothelial glycolysis in hypoxia.
Jeong H, Kim RI, Koo H, Choi YH, Kim M, Roh H, Park SG, Sung JH, Kim KL, Suh W. | 09/19/2024 |
| Effects of stem cell factor in follicular fluid and granulosa cells on oocyte maturity and clinical pregnancy. | Effects of stem cell factor in follicular fluid and granulosa cells on oocyte maturity and clinical pregnancy.
Wang X, Zhou L, Xu A, Nima D, Dong Z., Free PMC Article | 01/17/2024 |
| Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells. | Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells.
Franke K, Bal G, Li Z, Zuberbier T, Babina M., Free PMC Article | 05/19/2023 |
| DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway. | DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway.
Zhou Y, Huangfu S, Li M, Tang C, Qian J, Guo M, Zhou Z, Yang Y, Gu C., Free PMC Article | 10/29/2022 |
| KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect. | KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect.
Huang JC, Chen SC, Chang WA, Hung WW, Wu PH, Wu LY, Chang JM, Hsu YL, Tsai YC., Free PMC Article | 10/22/2022 |
| Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss. | Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss.
Vona B, Schwartzbaum DA, Rodriguez AA, Lewis SS, Toosi MB, Radhakrishnan P, Bozan N, Akın R, Doosti M, Manju R, Duman D, Sineni CJ, Nampoothiri S, Karimiani EG, Houlden H, Bademci G, Tekin M, Girisha KM, Maroofian R, Douzgou S., Free PMC Article | 08/27/2022 |
| The association of stem cell factor and soluble c-Kit (s-cKit) receptor serum concentrations with the severity and risk prediction of autism spectrum disorders. | The association of stem cell factor and soluble c-Kit (s-cKit) receptor serum concentrations with the severity and risk prediction of autism spectrum disorders.
Mashayekhi F, Shabani S, Sasani ST, Salehi Z. | 04/16/2022 |
| De novo mutation in KITLG gene causes a variant of Familial Progressive Hyper- and Hypo-pigmentation (FPHH). | De novo mutation in KITLG gene causes a variant of Familial Progressive Hyper- and Hypo-pigmentation (FPHH).
Gorenjak M, Fijačko N, Bogomir Marko P, Živanović M, Potočnik U., Free PMC Article | 03/26/2022 |
| Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation. | Identification of a novel mutation in the KITLG gene in a Chinese family with familial progressive hyper- and hypopigmentation.
Wang J, Li W, Zhou N, Liu J, Zhang S, Li X, Li Z, Yang Z, Sun M, Li M., Free PMC Article | 02/12/2022 |
| Tissue distribution of stem cell factor in adults. | Tissue distribution of stem cell factor in adults.
Foster BM, Langsten KL, Mansour A, Shi L, Kerr BA., Free PMC Article | 12/25/2021 |
| Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction. | Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction.
Mak ACY, Sajuthi S, Joo J, Xiao S, Sleiman PM, White MJ, Lee EY, Saef B, Hu D, Gui H, Keys KL, Lurmann F, Jain D, Abecasis G, Kang HM, Nickerson DA, Germer S, Zody MC, Winterkorn L, Reeves C, Huntsman S, Eng C, Salazar S, Oh SS, Gilliland FD, Chen Z, Kumar R, Martínez FD, Wu AC, Ziv E, Hakonarson H, Himes BE, Williams LK, Seibold MA, Burchard EG., Free PMC Article | 08/21/2021 |
| Stem cell factor is implicated in microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia. | Stem cell factor is implicated in microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia.
Gavriilidis GI, Ntoufa S, Papakonstantinou N, Kotta K, Koletsa T, Chartomatsidou E, Moysiadis T, Stavroyianni N, Anagnostopoulos A, Papadaki E, Tsiftsoglou AS, Stamatopoulos K., Free PMC Article | 07/10/2021 |
| Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. | Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.
Cao Z, Xie Y, Yu L, Li Y, Wang Y., Free PMC Article | 05/29/2021 |
| The mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes. | The mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes.
Frach L, Tierling S, Schwaiger M, Moser D, Heinrichs M, Hengstler JG, Walter J, Kumsta R. | 04/24/2021 |
| Novel mutation in the KITLG gene in familial progressive hyperpigmentation with or without hypopigmentation. | Novel mutation in the KITLG gene in familial progressive hyperpigmentation with or without hypopigmentation.
Kato M, Yagami A, Tsukamoto T, Shinkai Y, Kato T, Kurahashi H. | 03/20/2021 |
| High expression of KITLG is a new hallmark activating the MAPK pathway in type A and AB thymoma. | High expression of KITLG is a new hallmark activating the MAPK pathway in type A and AB thymoma.
Yang Z, Liu S, Wang Y, Chen Y, Zhang P, Liu Y, Zhang H, Zhang P, Tao Z, Xiong K., Free PMC Article | 03/13/2021 |
| The Mast Cell-SCF-CB1 Interaction Is a Key Player in Seborrheic Keratosis. | The Mast Cell-SCF-CB1 Interaction Is a Key Player in Seborrheic Keratosis.
Yamanaka-Takaichi M, Sugawara K, Sumitomo R, Tsuruta D., Free PMC Article | 12/12/2020 |
| SCF could help c-Kit(+) cancer stem cell survival in selective culture conditions and promote their canonical stemness properties, thus indicating the possible existence of a juxtacrine/paracrine circuit in epithelial ovarian cancer. | A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Mazzoldi EL, Pavan S, Pilotto G, Leone K, Pagotto A, Frezzini S, Nicoletto MO, Amadori A, Pastò A., Free PMC Article | 06/20/2020 |
| High SCF expression is associated with Hyperpigmented Skin Lesions. | The Role of Stem Cell Factor in Hyperpigmented Skin Lesions.
Atef A, El-Rashidy MA, Abdel Azeem A, Kabel AM., Free PMC Article | 06/6/2020 |
| Our findings suggest that SCF and C-kit receptors have a direct effect on the severity of aspirin-induced asthma. | Serum level of stem cell factor and its soluble receptor in aspirin-exacerbated respiratory disease.
Kalmarzi RN, Foroutan A, Abdi M, Ataee P, Jalili A, Babaei E, Kashefi H, Mohamadi S, Sigari N, Kooti W. | 05/23/2020 |
| The single nucleotide polymorphisms rs995030 and rs4474514 of the KITLG gene were not significantly correlated with male infertility | [Correlation of single nucleotide polymorphisms rs995030 and rs4474514 of the KITLG gene with male infertility].
Yin YL, Guo YM, Zhi HJ, Wu QY, Zhu PR, Liu HH, Xia XY. | 04/25/2020 |
| KITLG rs995030 A>G polymorphism might be associated with increased risk of testicular germ cell tumors. (Systematic Review; Meta-analysis) | Association between KITLG Gene Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-analysis.
Qin JX, Cai ZL, Yang YF, Xing JC, Zhuang X. | 02/22/2020 |