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    MICB MHC class I polypeptide-related sequence B [ Homo sapiens (human) ]

    Gene ID: 4277, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients.

    Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients.
    Niu Q, Li Z, Jiang H, Hu B.

    02/20/2024
    MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.

    MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.
    Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR.,

    01/5/2024
    Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).

    Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).
    Wang S, Onyeaghala GC, Pankratz N, Nelson HH, Thyagarajan B, Tang W, Norby FL, Ugoji C, Joshu CE, Gomez CR, Couper DJ, Coresh J, Platz EA, Prizment AE., Free PMC Article

    06/5/2023
    Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis.

    Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis.
    Wei A, Zhang L, Ma H, Cui L, Zhang Q, Wang D, Chen S, Du J, Zhao X, Wang T, Zhang R, Zheng H, Li Z.

    04/26/2023
    HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.

    HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.
    Al Hadra B, Lukanov TI, Ivanova MI.

    06/25/2022
    Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.

    Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.
    Petillo S, Capuano C, Molfetta R, Fionda C, Mekhloufi A, Pighi C, Antonangeli F, Zingoni A, Soriani A, Petrucci MT, Galandrini R, Paolini R, Santoni A, Cippitelli M., Free PMC Article

    01/29/2022
    Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus.

    Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus.
    Oliveira ERA, Li L, Bouvier M., Free PMC Article

    12/11/2021
    Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus.

    Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus.
    Hervier B, Ribon M, Tarantino N, Mussard J, Breckler M, Vieillard V, Amoura Z, Steinle A, Klein R, Kötter I, Decker P., Free PMC Article

    09/25/2021
    Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.

    Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.
    Ivanova M, Al Hadra B, Yordanov S, Lesichkova S, Stoyanov H, Shivarov V, Deliverska E.

    09/18/2021
    Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy.

    Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy.
    Basher F, Dhar P, Wang X, Wainwright DA, Zhang B, Sosman J, Ji Z, Wu JD., Free PMC Article

    05/22/2021
    Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.

    Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.
    Luangtrakool P, Vejbaesya S, Luangtrakool K, Ngamhawornwong S, Apisawes K, Kalayanarooj S, Macareo LR, Fernandez S, Jarman RG, Collins RWM, Cox ST, Srikiatkhachorn A, Rothman AL, Stephens HAF., Free PMC Article

    05/15/2021
    The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.

    The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.
    Sekiba K, Otsuka M, Seimiya T, Tanaka E, Funato K, Miyakawa Y, Koike K., Free PMC Article

    12/19/2020
    Expression of MIC B and upregulation of this molecule in response to IFN-gamma in cancer ASCs.

    Expression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals.
    Mansourabadi Z, Razmkhah M, Mohtasebi MS, Talei AR, Ghaderi A.

    08/1/2020
    For stage I-IV colorectal cancer (CRC) patients, MICB was confirmed a novel independent prognostic factor. It could help better stratification of CRC prognosis

    High MICB expression as a biomarker for good prognosis of colorectal cancer.
    Feng Q, Yu S, Mao Y, Ji M, Wei Y, He G, Chang W, Zhu D, Ren L, Xu J., Free PMC Article

    06/13/2020
    New haplotypes have been found in 3' untranslated regions of MICA and MICB genes in international histocompatibility workshop lymphoblastoid cell lines.

    Diversity and characterisation of polymorphic 3' untranslated region haplotypes of MICA and MICB genes.
    Cox ST, Hernandez D, Danby R, Turner TR, Madrigal JA.

    08/24/2019
    MICB gene seems to present two different lineages showing functional variations mainly in nucleotides of the promoter region

    Genetic polymorphism analysis of MICB gene in Jing ethnic minority of Southern China.
    Liu X, Chen X, Wei X, Meng Y, Liu L, Dai S.

    07/27/2019
    MiR-34a induces MICB expression in paratumor liver tissues.

    MicroRNA-34a promotes MICB expression in hepatocytes.
    Zhou MT, Zhao C, Chen X, Zhang HC, Li G, Lou H, Huang WJ, Wei LJ, Li DW, Wu X, Zhang ZC, Liu H, Ou R, Yang WJ, Hu S, Xu Y, Tang KF.

    06/15/2019
    Han Chinese people from Hainan Island carrying MICA*009 or MICA*A6 allele have a higher risk to rheumatoid arthritis while MICB*002 and MICB*014 provide a protective role against RA.

    MICB*002 and MICB*014 protect against rheumatoid arthritis, whereas MICA*009 and MICA*A6 are associated with rheumatoid arthritis in a Hainan Han Chinese population.
    Wang Y, Li S, Chen C, Luo Q, Li Y, Liu L, Fu X, Yu P, Wang F.

    06/1/2019
    MICB role in the genetic susceptibility to dengue disease.[meta-analysis]

    Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.
    Cahill ME, Conley S, DeWan AT, Montgomery RR., Free PMC Article

    05/4/2019
    MICB*005:03 allele (699G) is associated with acute lymphocytic (lymphoblastic) leukemia (ALL), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) in Korean population.

    Association of MICA and MICB polymorphisms with the susceptibility of leukemia in Korean patients.
    Baek IC, Shin DH, Choi EJ, Kim HJ, Yoon JH, Cho BS, Kim YJ, Lee S, Min WS, Kim HJ, Kim TG., Free PMC Article

    04/27/2019
    allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with respiratory syncytial virus respiratory tract infections.

    The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children.
    Luo Q, Guo X, Peng S, Luo W, Tian F, Yu P, Zou Y.

    06/30/2018
    the present study revealed that DNA damagedependent MICA/B expression in insensitive cancer cells can be restored by chromatin relaxation via the HDAC/Suv39/G9a pathway. Collectively, manipulation of chromatin status by therapeutic cancer drugs may potentiate the antitumor effect by enhancing immune activation following radiotherapy and DNA damage-associated chemotherapy.

    Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.
    Nakajima NI, Niimi A, Isono M, Oike T, Sato H, Nakano T, Shibata A., Free PMC Article

    04/7/2018
    The results of this study suggested that the MICB*009N allele might be a risk factor for SLE, whereas the MICB*014, MICA*010 and MICB*002 alleles were associated with reduced incidence of SLE in the study population.

    Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.
    Yu P, Zhu Q, Chen C, Fu X, Li Y, Liu L, Luo Q, Wang F, Wang Y.

    11/4/2017
    No association between MICB genotype and early viremia level in dengue patients.

    Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue.
    Whitehorn J, Kien DTH, Quyen NTH, Wills B, Van Vinh Chau N, Tam DTH, Tuan NM, Jaenisch T, Hibberd M, Khor CC, Simmons CP., Free PMC Article

    09/30/2017
    This demonstrates for the first time that MICA/B is more broadly expressed in normal tissue and that expression is mainly intracellular with only a small fraction appearing on the cell surface of some epithelia and tumour cells.

    MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.
    Ghadially H, Brown L, Lloyd C, Lewis L, Lewis A, Dillon J, Sainson R, Jovanovic J, Tigue NJ, Bannister D, Bamber L, Valge-Archer V, Wilkinson RW., Free PMC Article

    08/12/2017
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