| Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice. | Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice.
da Mata GE, Bricola R, Ribeiro DN, Simabuco FM, Pauli JR, de Freitas EC, Ropelle ER, da Silva ASR, Pinto AP. | 02/2/2024 |
| Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth. | Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Neyroud D, Laitano O, Dasgupta A, Lopez C, Schmitt RE, Schneider JZ, Hammers DW, Sweeney HL, Walter GA, Doles J, Judge SM, Judge AR., Free PMC Article | 05/15/2023 |
| Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics. | Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics.
Baehr LM, Hughes DC, Lynch SA, Van Haver D, Maia TM, Marshall AG, Radoshevich L, Impens F, Waddell DS, Bodine SC., Free PMC Article | 02/10/2023 |
| Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits. | Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits.
Lindqvist J, Kolb J, de Winter J, Tonino P, Hourani Z, Labeit S, Ottenheijm C, Granzier H., Free PMC Article | 08/6/2022 |
| Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility. | Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility.
Adams V, Schauer A, Augstein A, Kirchhoff V, Draskowski R, Jannasch A, Goto K, Lyall G, Männel A, Barthel P, Mangner N, Winzer EB, Linke A, Labeit S., Free PMC Article | 06/18/2022 |
| MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice. | MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
Sugiura K, Hirasaka K, Maeda T, Uchida T, Kishimoto K, Oarada M, Labeit S, Ulla A, Sakakibara I, Nakao R, Sairyo K, Nikawa T. | 04/16/2022 |
| MiR-29ab1 Cluster Resists Muscle Atrophy Through Inhibiting MuRF1. | MiR-29ab1 Cluster Resists Muscle Atrophy Through Inhibiting MuRF1.
Liu C, Li L, Ge M, Gu L, Zhang K, Su Y, Zhang Y, Liu C, Lan M, Yu Y, Wang T, Zhang B, Zhou G, Meng Q. | 09/25/2021 |
| Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model. | Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.
Nguyen T, Bowen TS, Augstein A, Schauer A, Gasch A, Linke A, Labeit S, Adams V., Free PMC Article | 07/31/2021 |
| Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1. | Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.
Labeit S, Hirner S, Bogomolovas J, Cruz A, Myrzabekova M, Moriscot A, Bowen TS, Adams V., Free PMC Article | 06/5/2021 |
| Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase. | Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase.
Hughes DC, Baehr LM, Driscoll JR, Lynch SA, Waddell DS, Bodine SC. | 12/19/2020 |
| The study reveals mechanisms by which MuRF1 may transcriptionally regulate anti-oxidant systems in the face of chronic hypoxia leading to right heart failure. | Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.
Oakley RH, Campen MJ, Paffett ML, Chen X, Wang Z, Parry TL, Hillhouse C, Cidlowski JA, Willis MS., Free PMC Article | 05/25/2019 |
| Oligonol-mediated downregulation of Atrogin-1 and MuRF1 gene expression alleviates muscle loss and improves the impaired myotube formation, indicating that oligonol supplementation may be useful for the attenuation of myotube loss. | Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1.
Liu HW, Chen YJ, Chang YC, Chang SJ., Free PMC Article | 09/8/2018 |
| the present study indicates that excessive glucocorticoids increased ubiquitin-proteasome system -dependent protein proteolysis via stimulating MuRF1, but not atrogin-1. | Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway.
Wang XJ, Xiao JJ, Liu L, Jiao HC, Lin H., Free PMC Article | 06/30/2018 |
| Dexamethasone-induced MuRF1 upregulation was significantly attenuated in C2C12 myotubes by resveratrol in vitro, but this effect on C2C12 myotubes was abrogated by a knockdown of NF-kappaB, suggesting that the beneficial effect of resveratrol was NF-kappaB dependent. Our findings provide novel information about the ability of resveratrol to prevent or treat muscle atrophy induced by CKD. | Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway.
Sun LJ, Sun YN, Chen SJ, Liu S, Jiang GR. | 06/24/2017 |
| Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase mediated by the reduction of Akt-FOXO3a signaling by oxidative stress. | Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway.
Ikeda Y, Imao M, Satoh A, Watanabe H, Hamano H, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. | 12/24/2016 |
| MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 mRNA expression was less affected by ageing | Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle.
Wagatsuma A, Shiozuka M, Takayama Y, Hoshino T, Mabuchi K, Matsuda R. | 11/5/2016 |
| MuRF1 directly interacts with PPARalpha, mono-ubiquitinates it, and targets it for nuclear export to inhibit fatty acid oxidation in a proteasome independent manner. | The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.
Rodríguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DJ, Frederick CB, Yoder BC, Lalush DS, Patterson C, Willis MS., Free PMC Article | 04/9/2016 |
| Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy. | Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy.
Han X, Pires L, Browne JD, Sullivan CA, Zhao W, Feng X. | 02/20/2016 |
| MURF1 was upregulated in cancer cachexia mice. | Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study.
Yuan L, Han J, Meng Q, Xi Q, Zhuang Q, Jiang Y, Han Y, Zhang B, Fang J, Wu G. | 01/2/2016 |
| Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles | Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS. | 11/28/2015 |
| Sunitinib is able to restrain the overactivation of STAT3 and MuRF-1 pathways, involved in enhanced muscle protein catabolism during cancer cachexia. | Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle.
Pretto F, Ghilardi C, Moschetta M, Bassi A, Rovida A, Scarlato V, Talamini L, Fiordaliso F, Bisighini C, Damia G, Bani MR, Piccirillo R, Giavazzi R., Free PMC Article | 11/28/2015 |
| provide evidence that high CO2 activates skeletal muscle atrophy via AMPKalpha2-FoxO3a-MuRF1, which is of biological and potentially clinical significance in patients with lung diseases and hypercapnia | High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1).
Jaitovich A, Angulo M, Lecuona E, Dada LA, Welch LC, Cheng Y, Gusarova G, Ceco E, Liu C, Shigemura M, Barreiro E, Patterson C, Nader GA, Sznajder JI., Free PMC Article | 06/20/2015 |
| an atrophic role for MuRF1 regulating the magnitude of right ventricular hypertrophy | Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling.
Campen MJ, Paffett ML, Colombo ES, Lucas SN, Anderson T, Nysus M, Norenberg JP, Gershman B, Hesterman J, Hoppin J, Willis M., Free PMC Article | 06/20/2015 |
| This data provides evidence for MuRF1 as a novel regulator of cardiac ROS, offering another mechanism by which increased MuRF1 expression may be cardioprotective in ischemia reperfusion injury. | MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo.
Mattox TA, Young ME, Rubel CE, Spaniel C, Rodríguez JE, Grevengoed TJ, Gautel M, Xu Z, Anderson EJ, Willis MS., Free PMC Article | 01/10/2015 |
| Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1. | Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line.
Bogomolovas J, Gasch A, Simkovic F, Rigden DJ, Labeit S, Mayans O., Free PMC Article | 01/10/2015 |