| A novel signature predicts recurrence risk and therapeutic response in breast cancer patients. | A novel signature predicts recurrence risk and therapeutic response in breast cancer patients.
Tran QH, Than VT, Luu PL, Clarke D, Lam HN, Nguyen TT, Nguyen DT, Duy PQ, Phung D, Nguyen MN. | 09/18/2021 |
| [Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].", trans "Assotsiatsiya polimorfizmov genov DDC (AADC), AANAT i ASMT, kodiruyushchikh fermenty sinteza melatonina, s riskom razvitiya psikhonevrologicheskikh rasstroistv. | [Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].
Moskaleva PV, Shnayder NA, Nasyrova RF. | 07/24/2021 |
| The pseudoautosomal region of human X and Y chromosome encoded ASMT protein was predicted to interact with many small molecules than that of interacting proteins. | Bioinformatics Annotation of Human Y Chromosome-Encoded Protein Pathways and Interactions.
Rengaraj D, Kwon WS, Pang MG. | 04/6/2020 |
| Low HIOMT expression is associated with lung cancer. | Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression.
Chen HL, Yuan CY, Cheng HH, Chang TC, Huang SK, Kuo CC, Wu KK., Free PMC Article | 02/16/2019 |
| Even when considering only high-grade glioma patients, a low ASMT:CYP1B1 value, which suggests decreased melatonin and enhanced aggressiveness, was strongly associated with poor survival. Overall, our data reveal the prognostic value of the melatonergic system of gliomas and provide insights into the therapeutic role of melatonin. | Melatonergic system-based two-gene index is prognostic in human gliomas.
Kinker GS, Oba-Shinjo SM, Carvalho-Sousa CE, Muxel SM, Marie SK, Markus RP, Fernandes PA. | 12/17/2016 |
| two single nucleotide polymorphisms (rs4446909 and rs5989681)in the promoter of ASMT do not contribute to the pathogenesis of schizophrenia in Chinese-Han subjects | ASMT gene polymorphisms have no association with schizophrenia in a Han Chinese sample.
Cong Z, Li X, Lin A, Zhu G, Peng M, Wang Y, Huang Y, Jiang W, Zhao X, Peng L, Ma H. | 06/11/2016 |
| results indicate that expression of sleep onset delay relates to melatonin pathway genes. | Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.
Veatch OJ, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, Malow BA., Free PMC Article | 08/15/2015 |
| These data suggest a relationship between decreased mRNA and protein expression levels of ASMT gene and cognitive impairment. | ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder.
Talarowska M, Szemraj J, Zajączkowska M, Gałecki P., Free PMC Article | 12/20/2014 |
| Bipolar disorder-associated SNP influences sleep and circadian rhythms in bipolar patients in remission and controls. | An ASMT variant associated with bipolar disorder influences sleep and circadian rhythms: a pilot study.
Geoffroy PA, Boudebesse C, Henrion A, Jamain S, Henry C, Leboyer M, Bellivier F, Etain B. | 11/8/2014 |
| study presents the X-ray crystal structure of ASMT; analysis of nonsynonymous variants found that the majority of these mutations reduced or abolished ASMT activity; estimate the allelic frequency of ASMT deleterious mutations ranges from 0.66% in Europe to 2.97% in Asia | Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.
Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T. | 09/27/2014 |
| results support the possible involvement of the ASMT gene in autism spectrum disorders | Association between ASMT and autistic-like traits in children from a Swedish nationwide cohort.
Jonsson L, Anckarsäter H, Zettergren A, Westberg L, Walum H, Lundström S, Larsson H, Lichtenstein P, Melke J. | 08/9/2014 |
| ASMT might be a susceptibility gene for autism | Sequencing ASMT identifies rare mutations in Chinese Han patients with autism.
Wang L, Li J, Ruan Y, Lu T, Liu C, Jia M, Yue W, Liu J, Bourgeron T, Zhang D., Free PMC Article | 07/13/2013 |
| Rare and common variations in ASMT might play a role in bipolar disorder vulnerability. | Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.
Etain B, Dumaine A, Bellivier F, Pagan C, Francelle L, Goubran-Botros H, Moreno S, Deshommes J, Moustafa K, Le Dudal K, Mathieu F, Henry C, Kahn JP, Launay JM, Mühleisen TW, Cichon S, Bourgeron T, Leboyer M, Jamain S. | 01/26/2013 |
| Data found a splice site mutation in ASMT (IVS5+2T>C) and one stop mutation in MTNR1A (Y170X) - detected exclusively in patients with ADHD - for which biochemical analyses indicated that they abolish the activity of ASMT and MTNR1A. | Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.
Chaste P, Clement N, Botros HG, Guillaume JL, Konyukh M, Pagan C, Scheid I, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg IC, Melke J, Delorme R, Leblond C, Toro R, Huguet G, Fauchereau F, Durand C, Boudarene L, Serrano E, Lemière N, Launay JM, Leboyer M, Jockers R, Gillberg C, Bourgeron T. | 06/2/2012 |
| There is dysregulation of the AANAT/ASMT/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth. | Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.
Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, Meng F, Venter J, Bernuzzi F, White M, Francis H, Lleo A, Marzioni M, Onori P, Alvaro D, Torzilli G, Gaudio E, Alpini G., Free PMC Article | 11/19/2011 |
| The expression of HIOMT in epithelial cells of striated ducts in human submandibular glands. | Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands.
Shimozuma M, Tokuyama R, Tatehara S, Umeki H, Ide S, Mishima K, Saito I, Satomura K. | 10/15/2011 |
| study of genetic variability of ASMT in a cohort of patients with intellectual disability (ID)and controls; identifed patients with deleterious ASMT mutations and decreased ASMT activity; however, study does not support ASMT as a causative gene for ID | Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.
Pagan C, Botros HG, Poirier K, Dumaine A, Jamain S, Moreno S, de Brouwer A, Van Esch H, Delorme R, Launay JM, Tzschach A, Kalscheuer V, Lacombe D, Briault S, Laumonnier F, Raynaud M, van Bon BW, Willemsen MH, Leboyer M, Chelly J, Bourgeron T., Free PMC Article | 06/18/2011 |
| Results show the AA genotype and the GG genotype of ASMT were associated with lower risk for having recurrent depressive disorder. In turn, patients with depression were characterised by reduced mRNA expression for ASMT. | Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.
Gałecki P, Szemraj J, Bartosz G, Bieńkiewicz M, Gałecka E, Florkowski A, Lewiński A, Karbownik-Lewińska M, Gałecki P, Szemraj J, Bartosz G, Bieńkiewicz M, Gałecka E, Florkowski A, Lewiński A, Karbownik-Lewińska M. | 08/9/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Linkage and candidate gene studies of autism spectrum disorders in European populations.
Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP, EU Autism MOLGEN Consortium., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesSingle-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.
Gałecki P, Szemraj J, Bartosz G, Bieńkiewicz M, Gałecka E, Florkowski A, Lewiński A, Karbownik-Lewińska M, Gałecki P, Szemraj J, Bartosz G, Bieńkiewicz M, Gałecka E, Florkowski A, Lewiński A, Karbownik-Lewińska M. Mutation screening of melatonin-related genes in patients with autism spectrum disorders.
Jonsson L, Ljunggren E, Bremer A, Pedersen C, Landén M, Thuresson K, Giacobini M, Melke J. | 06/30/2010 |
| The results of this study indicated that HIOMT immunohistochemistry may be useful for the diagnosis of PPTs and be a prognostic factor in pineal parenchymal cell tumors. | Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, Akimoto J, Tanaka M, Okada Y, Saito S. | 05/31/2010 |
| Two polymorphisms located in the acetylserotonin methyltransferase (ASMT)promoter were more frequent in autism spectrum disorders (ASD); analyses revealed a highly significant decrease in ASMT activity and melatonin level in individuals with ASD. | Abnormal melatonin synthesis in autism spectrum disorders.
Melke J, Goubran Botros H, Chaste P, Betancur C, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg IC, Delorme R, Chabane N, Mouren-Simeoni MC, Fauchereau F, Durand CM, Chevalier F, Drouot X, Collet C, Launay JM, Leboyer M, Gillberg C, Bourgeron T., Free PMC Article | 01/21/2010 |
| The data of this study does not support a correleation between asmt gene and autism. | Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.
Toma C, Rossi M, Sousa I, Blasi F, Bacchelli E, Alen R, Vanhala R, Monaco AP, Järvelä I, Maestrini E, International Molecular Genetic Study of Autism Consortium. | 01/21/2010 |