| Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis. | Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis.
Falkowski K, Bielecka E, Thøgersen IB, Bocheńska O, Płaza K, Kalińska M, Sąsiadek L, Magoch M, Pęcak A, Wiśniewska M, Gruba N, Wysocka M, Wojtysiak A, Brzezińska-Bodal M, Sychowska K, Pejkovska A, Rehders M, Butler G, Overall CM, Brix K, Dubin G, Lesner A, Kozik A, Enghild JJ, Potempa J, Kantyka T., Free PMC Article | 02/13/2021 |
| The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. | The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.
Kryza T, Bock N, Lovell S, Rockstroh A, Lehman ML, Lesner A, Panchadsaram J, Silva LM, Srinivasan S, Snell CE, Williams ED, Fazli L, Gleave M, Batra J, Nelson C, Tate EW, Harris J, Hooper JD, Clements JA., Free PMC Article | 02/6/2021 |
| Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature. | Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature.
Gouin O, Barbieux C, Leturcq F, Bonnet des Claustres M, Petrova E, Hovnanian A. | 01/9/2021 |
| There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. High KLK14 mRNA levels were significantly associated with prolonged PFS (HR = 0.44, P = 0.017) and showed a trend towards significance for OS (HR = 0.55, P = 0.070). | Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis.
Dettmar L, Ahmed N, Kotzsch M, Diersch S, Napieralski R, Darmoul D, Schmitt M, Weichert W, Kiechle M, Dorn J, Magdolen V. | 06/16/2018 |
| In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled. | KLK14 interactions with HAI-1 and HAI-2 serine protease inhibitors: A molecular dynamics and relative free-energy calculations study.
Solís-Calero C, Carvalho HF. | 04/14/2018 |
| increased KLK14 activity could contribute at multiple levels to HGF/Met-mediated processes in prostate and other cancers | In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B.
Reid JC, Bennett NC, Stephens CR, Carroll ML, Magdolen V, Clements JA, Hooper JD. | 07/8/2017 |
| KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients. | Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7KLK14) in colon cancer.
Devetzi M, Trangas T, Scorilas A, Xynopoulos D, Talieri M. | 11/16/2013 |
| KLK8 and KLK14 can signal differentially via the PARs to affect tissue function | Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14.
Ramachandran R, Eissa A, Mihara K, Oikonomopoulou K, Saifeddine M, Renaux B, Diamandis E, Hollenberg MD. | 09/1/2012 |
| KLK14, acting via PAR-2, represents an autocrine/paracrine regulator of colon tumorigenesis | Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Chung H, Hamza M, Oikonomopoulou K, Gratio V, Saifeddine M, Virca GD, Diamandis EP, Hollenberg MD, Darmoul D. | 09/1/2012 |
| genetic variants in the KLK14 locus are associated with risk and/or aggressiveness of prostate cancer | The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness.
Lose F, Lawrence MG, Srinivasan S, O'Mara T, Marquart L, Chambers S, Gardiner RA, Aitken JF, Spurdle AB, Batra J, Clements JA, Australian Prostate Cancer BioResource. | 09/1/2012 |
| KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies. | Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues.
Papachristopoulou G, Avgeris M, Charlaftis A, Scorilas A. | 05/21/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Klein RJ, Halldén C, Cronin AM, Ploner A, Wiklund F, Bjartell AS, Stattin P, Xu J, Scardino PT, Offit K, Vickers AJ, Grönberg H, Lilja H., Free PMC Article | 06/30/2010 |
| The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. | Human kallikrein 14 (KLK14) expression in salivary gland tumors.
Hashem NN, Mara TW, Mohamed M, Zhang I, Fung K, Kwan KF, Daley TD, Diamandis EP, Darling MR. | 06/28/2010 |
| Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 showed very strong discriminatory potential for semen liquefaction and viscosity, respectively. | Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility.
Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis EP. | 01/21/2010 |
| synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. | Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor.
Paliouras M, Diamandis EP., Free PMC Article | 01/21/2010 |
| KLK4 is only expressed in breast and prostate cancers that express the progesterone receptor (PR) and androgen receptor (AR), respectively. | Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer.
Lai J, Myers SA, Lawrence MG, Odorico DM, Clements JA. | 01/21/2010 |
| positive staining was significantly associated with NSCLC adenocarcinoma histotype (KLK13, p=0.014) and tumor size (KLK14, p=0.048) | Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung.
Planque C, Bléchet C, Ayadi-Kaddour A, Heuzé-Vourc'h N, Dumont P, Guyétant S, Diamandis EP, El Mezni F, Courty Y. | 01/21/2010 |
| semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity. | Major role of human KLK14 in seminal clot liquefaction.
Emami N, Deperthes D, Malm J, Diamandis EP. | 01/21/2010 |
| Expression of the KLK14 protein correlated with the pathological tumor status in prostate cancer and was associated with disease progression defined by prostate-specific antigen relapse in univariate Kaplan-Meier analysis. | High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse.
Rabien A, Fritzsche F, Jung M, Diamandis EP, Loening SA, Dietel M, Jung K, Stephan C, Kristiansen G. | 01/21/2010 |
| KLK14 is a new activator component of the KLK proteolytic cascade with a possible role in seminal plasma and skin | Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin.
Emami N, Diamandis EP. | 01/21/2010 |
| KLK5 and KLK14, but neither KLK7 nor KLK8, induced PAR2 signalling. | Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.
Stefansson K, Brattsand M, Roosterman D, Kempkes C, Bocheva G, Steinhoff M, Egelrud T. | 01/21/2010 |
| may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance. | A proteolytic cascade of kallikreins in the stratum corneum.
Brattsand M, Stefansson K, Lundh C, Haasum Y, Egelrud T. | 01/21/2010 |
| The majority of KLK14 in the plantar stratum corneum is present in its catalytically active form. KLK14 could be immunohistochemically detected in sweat ducts, preferentially in the intraepidermal parts (the acrosyringium), and in sweat glands. | Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.
Stefansson K, Brattsand M, Ny A, Glas B, Egelrud T. | 01/21/2010 |
| KLK14 may be implicated in several facets of tumor progression, including growth, invasion, and angiogenesis, as well as in arthritic disease via deterioration of cartilage | Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.
Borgoño CA, Michael IP, Shaw JL, Luo LY, Ghosh MC, Soosaipillai A, Grass L, Katsaros D, Diamandis EP. | 01/21/2010 |
| KLK14 expression upregulated in advanced and more aggressive prostate tumors; may play role in tumor spread and may be new marker for prostate cancer diagnosis and prognosis | Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues.
Yousef GM, Stephan C, Scorilas A, Ellatif MA, Jung K, Kristiansen G, Jung M, Polymeris ME, Diamandis EP. | 01/21/2010 |