| PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport. | PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
Miner GE, So CM, Edwards W, Ragusa JV, Wine JT, Wong Gutierrez D, Airola MV, Herring LE, Coleman RA, Klett EL, Cohen S., Free PMC Article | 08/3/2023 |
| Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I. | Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I.
Ethem İ, Hacıoğlu C., Free PMC Article | 10/1/2022 |
| Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative Tissues. | Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative Tissues.
Zhang X, Xu W, Xu R, Wang Z, Zhang X, Wang P, Peng K, Li M, Li J, Tan Y, Wang X, Pei H., Free PMC Article | 04/30/2022 |
| Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes. | Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes.
Fachada V, Rahkila P, Fachada N, Turpeinen T, Kujala UM, Kainulainen H. | 04/16/2022 |
| Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals. | Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals.
Gemmink A, Daemen S, Brouwers B, Hoeks J, Schaart G, Knoops K, Schrauwen P, Hesselink MKC. | 04/24/2021 |
| Lsdp5 expression is instrumental for reducing lipotoxicity in cultured liver cells. | Lipid storage droplet protein 5 reduces sodium palmitate‑induced lipotoxicity in human normal liver cells by regulating lipid metabolism‑related factors.
Ma X, Cheng F, Yuan K, Jiang K, Zhu T., Free PMC Article | 12/14/2019 |
| Even though total PLIN5 protein content was almost double in Trained versus type 2 diabetes patients, PLIN5 coating did not affect lipid droplet number or size significantly. | Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?
Gemmink A, Daemen S, Brouwers B, Huntjens PR, Schaart G, Moonen-Kornips E, Jörgensen J, Hoeks J, Schrauwen P, Hesselink MKC., Free PMC Article | 08/24/2019 |
| perilipin 5 is not restricted to certain cell types but localizes to distinct lipid droplet subpopulations reflecting a possible function in oxidative energy supply in normal tissues and in diseases. | Widespread expression of perilipin 5 in normal human tissues and in diseases is restricted to distinct lipid droplet subpopulations.
Hashani M, Witzel HR, Pawella LM, Lehmann-Koch J, Schumacher J, Mechtersheimer G, Schnölzer M, Schirmacher P, Roth W, Straub BK. | 06/22/2019 |
| Using two super-resolution imaging approaches, the study shows that in sections of human skeletal muscle PLIN2 and PLIN5 localize to lipid droplets (LD) at distinct sites, with abundance of PLIN5 at LD-mitochondria tethering sites. | Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2.
Gemmink A, Daemen S, Kuijpers HJH, Schaart G, Duimel H, López-Iglesias C, van Zandvoort MAMJ, Knoops K, Hesselink MKC. | 06/8/2019 |
| The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. | Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle.
Laurens C, Bourlier V, Mairal A, Louche K, Badin PM, Mouisel E, Montagner A, Marette A, Tremblay A, Weisnagel JS, Guillou H, Langin D, Joanisse DR, Moro C., Free PMC Article | 06/2/2018 |
| Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. | Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.
Bernsmeier C, Dill MT, Provenzano A, Makowska Z, Krol I, Muscogiuri G, Semela D, Tornillo L, Marra F, Heim MH, Duong FH. | 06/24/2017 |
| High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. | Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men.
Vigelso A, Prats C, Ploug T, Dela F, Helge JW. | 03/18/2017 |
| PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. | Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise.
Mason RR, Meex RC, Russell AP, Canny BJ, Watt MJ., Free PMC Article | 11/21/2015 |
| Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization | Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.
Kimmel AR, Sztalryd C., Free PMC Article | 11/8/2014 |
| Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 | Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5.
Shepherd SO, Cocks M, Tipton KD, Ranasinghe AM, Barker TA, Burniston JG, Wagenmakers AJ, Shaw CS., Free PMC Article | 08/3/2013 |
| PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. | Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training.
Peters SJ, Samjoo IA, Devries MC, Stevic I, Robertshaw HA, Tarnopolsky MA. | 09/29/2012 |
| The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. | The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.
Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, Duimel H, Kersten S, Bickel PE, Schrauwen P, Hesselink MK., Free PMC Article | 07/7/2012 |
| Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] | Oxidative tissue: perilipin 5 links storage with the furnace.
Wang H, Sztalryd C., Free PMC Article | 10/22/2011 |
| interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. | Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein.
Wang H, Bell M, Sreenivasan U, Sreenevasan U, Hu H, Liu J, Dalen K, Londos C, Yamaguchi T, Rizzo MA, Coleman R, Gong D, Brasaemle D, Sztalryd C., Free PMC Article | 07/2/2011 |
| Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. | Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
Minnaard R, Schrauwen P, Schaart G, Jorgensen JA, Lenaers E, Mensink M, Hesselink MK. | 01/21/2010 |