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    MIR302B microRNA 302b [ Homo sapiens (human) ]

    Gene ID: 442894, updated on 13-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFbeta/SMAD2 axis.

    Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis.
    Paw M, Kusiak AA, Nit K, Litewka JJ, Piejko M, Wnuk D, Sarna M, Fic K, Stopa KB, Hammad R, Barczyk-Woznicka O, Cathomen T, Zuba-Surma E, Madeja Z, Ferdek PE, Bobis-Wozowicz S., Free PMC Article

    11/3/2023
    LncRNA XIST facilitates hypertrophy of ligamentum flavum by activating VEGFA-mediated autophagy through sponging miR-302b-3p.

    LncRNA XIST facilitates hypertrophy of ligamentum flavum by activating VEGFA-mediated autophagy through sponging miR-302b-3p.
    Cao Y, Li J, Qiu S, Ni S, Duan Y., Free PMC Article

    05/26/2023
    Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma.

    Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma.
    Cheng S, Wang W.

    07/9/2022
    Silencing of miR-302b-3p alleviates isoflurane-induced neuronal injury by regulating PTEN expression and AKT pathway.

    Silencing of miR-302b-3p alleviates isoflurane-induced neuronal injury by regulating PTEN expression and AKT pathway.
    Li L, Lu S, Fan X.

    01/8/2022
    Low expression of lncRNA SBF2-AS1 regulates the miR-302b-3p/TGFBR2 axis, promoting metastasis in laryngeal cancer.

    Low expression of lncRNA SBF2-AS1 regulates the miR-302b-3p/TGFBR2 axis, promoting metastasis in laryngeal cancer.
    Li Y, Tang B, Lyu K, Yue H, Wei F, Xu Y, Chen S, Lin Y, Cai Z, Guo X, Li C, Lei W.

    12/25/2021
    SOX-17 is involved in invasion and apoptosis of colorectal cancer cells through regulating miR-302b-3p expression.

    SOX-17 is involved in invasion and apoptosis of colorectal cancer cells through regulating miR-302b-3p expression.
    Hu F, Li M, Mo L, Xiao Y, Wang X, Xie B.

    11/27/2021
    LncUBE2R2-AS1 acts as a microRNA sponge of miR-302b to promote HCC progression via activation EGFR-PI3K-AKT signaling pathway.

    LncUBE2R2-AS1 acts as a microRNA sponge of miR-302b to promote HCC progression via activation EGFR-PI3K-AKT signaling pathway.
    Wu Z, Wei ZH, Chen SH., Free PMC Article

    11/22/2021
    Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis.

    Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis.
    Wang D, Jiang X, Liu Y, Cao G, Zhang X, Kuang Y.

    07/17/2021
    MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in OSCC.

    MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in OSCC.
    Sun S, Wang J, Liu J, Yin F, Xin C, Zeng X, Li J, Chen Q.

    07/17/2021
    MiR-302b-5p enhances the neuroprotective effect of IGF-1 in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease by regulating inducible nitric-oxide synthase.

    MiR-302b-5p enhances the neuroprotective effect of IGF-1 in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease by regulating inducible nitric-oxide synthase.
    Cui X, Li M, He Z, Hu L, Liu J, Yan J, Hua L.

    05/29/2021
    Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1alpha Activation.

    Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.
    Mas-Bargues C, Sanz-Ros J, Román-Domínguez A, Gimeno-Mallench L, Inglés M, Viña J, Borrás C., Free PMC Article

    04/17/2021
    miRNA-302s may act as oncogenes in human testicular germ cell tumours.

    miRNA-302s may act as oncogenes in human testicular germ cell tumours.
    Das MK, Evensen HSF, Furu K, Haugen TB., Free PMC Article

    10/24/2020
    The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity.

    The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity.
    Yasukawa K, Kinoshita D, Yaku K, Nakagawa T, Koshiba T., Free PMC Article

    09/19/2020
    Our findings indicate that miR-302b-5p might suppress hepatocellular carcinoma progression

    Evaluation of miR-302b-5p expression and molecular mechanism in hepatocellular carcinoma: Findings based on RT-qPCR and in silico analysis.
    Wu HY, Cai KT, Ma J, Chen G, Dang YW, Lu HP, Pan SL.

    01/18/2020
    our results indicate that miR-302b functions as a tumour repressor in the invasion and migration of osteosarcoma by directly downregulating Runx2 expression and may be a potential therapeutic target for osteosarcoma.

    MiR-302b Suppresses Osteosarcoma Cell Migration and Invasion by Targeting Runx2.
    Xie Y, Sun W, Deng Z, Zhu X, Hu C, Cai L., Free PMC Article

    07/6/2019
    the aim of the present study was to compare the plasma levels of miR-302b between patients following acute myocardial infarction and healthy subjects.

    Serum microRNA-302b: the novel biomarker for diagnosis of acute myocardial infarction.
    Yang S, Fu C, Xu R, Xun Z, Zhao X, Fang R.

    06/29/2019
    Data show that interleukin 1 receptor associated kinase 4 (IRAK4) and EPH receptor A2 (EphA2) were the functional targets of miR-302b.

    MicroRNA-302b negatively regulates IL-1β production in response to MSU crystals by targeting IRAK4 and EphA2.
    Ma T, Liu X, Cen Z, Xin C, Guo M, Zou C, Song W, Xie R, Wang K, Zhou H, Zhang J, Wang Z, Bian C, Cui K, Li J, Wei YQ, Li J, Zhou X., Free PMC Article

    05/18/2019
    The abrogation of DDX6 expression inhibited iPSC generation, which was mediated by RNA decay targeting parental mRNAs supporting mesenchymal phenotypes, along with microRNAs, such as miR-302b-3p

    The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency.
    Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S., Free PMC Article

    03/9/2019
    The overexpression of miR-302b-3p downregulated the protein levels of GCNT3, N-cadherin, vimentin, and p-Erk and elevated the levels of E-cadherin.

    Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion.
    Li Q, Ran P, Zhang X, Guo X, Yuan Y, Dong T, Zhu B, Zheng S, Xiao C.

    11/10/2018
    Study showed that miR-302 microRNA cluster genes are involved in in vitro dedifferentiation of human pancreatic islet cells and inhibits the expression of multiple genes involved in the maintenance of beta-cell mature phenotype.

    MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s.
    Sebastiani G, Grieco GE, Brusco N, Ventriglia G, Formichi C, Marselli L, Marchetti P, Dotta F., Free PMC Article

    09/15/2018
    Low miR302b expression is associated with epithelial-mesenchymal transition in gastric cancer.

    miR-302b inhibits tumorigenesis by targeting EphA2 via Wnt/ β-catenin/EMT signaling cascade in gastric cancer.
    Huang J, He Y, Mcleod HL, Xie Y, Xiao D, Hu H, Chen P, Shen L, Zeng S, Yin X, Ge J, Li L, Tang L, Ma J, Chen Z., Free PMC Article

    08/18/2018
    These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC.

    miR-302b inhibits cancer-related inflammation by targeting ERBB4, IRF2 and CXCR4 in esophageal cancer.
    Zhang M, Zhang L, Cui M, Ye W, Zhang P, Zhou S, Wang J., Free PMC Article

    04/28/2018
    The upregulation of miR-302b reduced the expression of CDK2, and inhibited ERK signaling pathway, thereby inhibiting cell proliferation and G1/S phase conversion rate.

    miR-302b regulates cell cycles by targeting CDK2 via ERK signaling pathway in gastric cancer.
    Liu FY, Wang LP, Wang Q, Han P, Zhuang WP, Li MJ, Yuan H., Free PMC Article

    11/18/2017
    MicroRNA-302b-3p suppresses cell proliferation through AKT pathway by targeting IGF-1R in human gastric cancer.

    MicroRNA-302b-3p Suppresses Cell Proliferation Through AKT Pathway by Targeting IGF-1R in Human Gastric Cancer.
    Guo B, Zhao Z, Wang Z, Li Q, Wang X, Wang W, Song T, Huang C.

    10/28/2017
    We verified that NFIA binds to the IGFBP2 promoter and transcriptionally enhances IGFBP2 expression levels. We identified that NFIA-mediated IGFBP2 signaling pathways are involved in miR-302b-induced glioma cell death.

    The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA.
    Lee CC, Chen PH, Ho KH, Shih CM, Cheng CH, Lin CW, Cheng KT, Liu AJ, Chen KC., Free PMC Article

    08/26/2017
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