| MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression. | MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression.
Wang S, Wang K, Yue D, Yang X, Pan X, Kong F, Zhao R, Bie Q, Tian D, Zhu S, He B, Bin Z., Free PMC Article | 09/27/2024 |
| Bioinformatics analysis and validation of mesenchymal stem cells related gene MT1G in osteosarcoma. | Bioinformatics analysis and validation of mesenchymal stem cells related gene MT1G in osteosarcoma.
Zheng S, Cheng X, Ke S, Zhang L, Wu H, He D, Cheng X., Free PMC Article | 05/28/2024 |
| MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation, Invasion and Migration and Promote Apoptosis in Colon Cancer Cells. | MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation, Invasion and Migration and Promote Apoptosis in Colon Cancer Cells.
Li J, Hu Q, Li Z, Feng K, Li K. | 04/8/2024 |
| The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. | The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity.
Tong ZB, Braisted J, Chu PH, Gerhold D., Free PMC Article | 08/21/2021 |
| Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-kappaB inhibition. | Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition.
Li K, Zhang Z, Mei Y, Yang Q, Qiao S, Ni C, Yao Y, Li X, Li M, Wei D, Fu W, Guo X, Huang X, Yang H., Free PMC Article | 07/31/2021 |
| Upregulation of Metallothionein-1G Accelerates G1/S Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells. | Upregulation of Metallothionein-1G Accelerates G1/S Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells.
Hirako N, Takahashi S. | 07/3/2021 |
| Multivariate analysis indicated that RUNX3 and CDH1 promoter methylation were independent prognostic factors for overall survival (P = 0.03 and 0.04; respectively), while DAPK1, RUNX3 and MT1G PM were independent prognostic factors for disease free survival. | The prognostic impact of hypermethylation for a panel of tumor suppressor genes and cell of origin subtype on diffuse large B-cell lymphoma.
Shawky SA, El-Borai MH, Khaled HM, Guda I, Mohanad M, Abdellateif MS, Zekri AN, Bahanasy AA. | 02/15/2020 |
| In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression | DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
Maleckaite R, Zalimas A, Bakavicius A, Jankevicius F, Jarmalaite S, Daniunaite K. | 08/24/2019 |
| These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells. | Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
Houessinon A, François C, Sauzay C, Louandre C, Mongelard G, Godin C, Bodeau S, Takahashi S, Saidak Z, Gutierrez L, Régimbeau JM, Barget N, Barbare JC, Ganne N, Chauffert B, Coriat R, Galmiche A., Free PMC Article | 06/24/2017 |
| A new tumor-suppressor activity of MT1G in colorectal cancer cells.MT1G role in cell differentiation. | Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells.
Arriaga JM, Bravo AI, Mordoh J, Bianchini M., Free PMC Article | 06/24/2017 |
| PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation | A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation.
Hirako N, Nakano H, Takahashi S., Free PMC Article | 11/14/2015 |
| MT1G was down-regulated in renal cell carcinogenesis. | An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
Alkamal I, Ikromov O, Tölle A, Fuller TF, Magheli A, Miller K, Krause H, Kempkensteffen C. | 11/7/2015 |
| MT1M and MT1G promoter methylation may be used as serum biomarkers for noninvasive detection of hepatocellular carcinoma. | MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma.
Ji XF, Fan YC, Gao S, Yang Y, Zhang JJ, Wang K., Free PMC Article | 04/18/2015 |
| Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. | Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy.
Arriaga JM, Greco A, Mordoh J, Bianchini M. | 01/3/2015 |
| Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. | Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway.
Fu J, Lv H, Guan H, Ma X, Ji M, He N, Shi B, Hou P., Free PMC Article | 06/28/2014 |
| GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired multidrug resistance of lung adenocarcinoma. | Promoter methylation profiles between human lung adenocarcinoma multidrug resistant A549/cisplatin (A549/DDP) cells and its progenitor A549 cells.
Guo R, Wu G, Li H, Qian P, Han J, Pan F, Li W, Li J, Ji F. | 02/22/2014 |
| MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts. | Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH. | 04/30/2011 |
| Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia. | Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
Raymond AD, Gekonge B, Giri MS, Hancock A, Papasavvas E, Chehimi J, Kossenkov AV, Nicols C, Yousef M, Mounzer K, Shull J, Kostman J, Showe L, Montaner LJ., Free PMC Article | 10/4/2010 |
| Results describe MT1G promoter hypermethylation in hepatoblastoma and demonstrate that aberrant methylation is a frequent event in this malignancy. | MT1G hypermethylation: a potential prognostic marker for hepatoblastoma.
Sakamoto LH, DE Camargo B, Cajaiba M, Soares FA, Vettore AL. | 05/31/2010 |
| p16INK4A, DAPK1, PTEN and MT1G genes were not frequently methylated in the stage I non-small cell lung cancer in China. | RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, Bao G, Chen Y, Zhang H, He Y, Luo X, Feng X, Zhu J. | 01/21/2010 |
| MT1G acts as a tumor suppressor gene in hepatocellular carcinoma | Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis.
Kanda M, Nomoto S, Okamura Y, Nishikawa Y, Sugimoto H, Kanazumi N, Takeda S, Nakao A. | 01/21/2010 |
| Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively. | Genome-wide screen of promoter methylation identifies novel markers in melanoma.
Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro AM, Halaban R, Weissman SM., Free PMC Article | 01/21/2010 |
| Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC. | Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma.
Adams L, Roth MJ, Abnet CC, Dawsey SP, Qiao YL, Wang GQ, Wei WQ, Lu N, Dawsey SM, Woodson K., Free PMC Article | 01/21/2010 |
| MT1G is hypermethylated in renal cell carcinoma. | Identification of novel epigenetic markers for clear cell renal cell carcinoma.
Dalgin GS, Drever M, Williams T, King T, DeLisi C, Liou LS. | 01/21/2010 |
| Induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors. | Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.
Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S. | 01/21/2010 |