| Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro. | Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro.
Yao W, Chen X, Cui X, Zhou B, Zhao B, Lin Z, Miao J. | 10/25/2023 |
| Single-cell transcriptome analysis revealing the intratumoral heterogeneity of ccRCC and validation of MT2A in pathogenesis. | Single-cell transcriptome analysis revealing the intratumoral heterogeneity of ccRCC and validation of MT2A in pathogenesis.
Wang J, Zuo Z, Yu Z, Chen Z, Meng X, Ma Z, Niu J, Guo R, Tran LJ, Zhang J, Jiang T, Ye F, Ma B, Sun Z. | 09/18/2023 |
| An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies. | An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies.
Michalczyk K, Kapczuk P, Witczak G, Tousty P, Bosiacki M, Kurzawski M, Chlubek D, Cymbaluk-Płoska A., Free PMC Article | 03/30/2023 |
| Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese. | Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese.
Chen RF, Chen PM, Pan CS, Huang CC, Chiang EI., Free PMC Article | 02/4/2023 |
| ptk2 and mt2a Genes Expression in Gastritis and Gastric Cancer Patients with Helicobacter pylori Infection. | ptk2 and mt2a Genes Expression in Gastritis and Gastric Cancer Patients with Helicobacter pylori Infection.
Ahmadi Hedayati M, Khani D, Sheikhesmaeili F, Nouri B., Free PMC Article | 09/17/2022 |
| Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells. | Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells.
Dias AM, de Mendonça RP, da Silva Kataoka MS, Jaeger RG, de Jesus Viana Pinheiro J, de Melo Alves Junior S. | 06/18/2022 |
| Structural basis of the ligand binding and signaling mechanism of melatonin receptors. | Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y., Free PMC Article | 02/19/2022 |
| Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice. | Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice.
Huang S, Wang J, Men H, Tan Y, Lin Q, Gozal E, Zheng Y, Cai L., Free PMC Article | 02/5/2022 |
| Effect of MT2A on apoptosis and proliferation in HL60 cells. | Effect of MT2A on apoptosis and proliferation in HL60 cells.
Pan YQ, Niu M, Liu SM, Bao YX, Yang K, Ma XB, He L, Li YX, Cao JX, Zhang X, Du Y., Free PMC Article | 12/11/2021 |
| Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk. | Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk.
Wang J, Huang P, Zhao W, Ren W, Ai L, Wu L., Free PMC Article | 07/10/2021 |
| MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells. | MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells.
Zhao Z, Zhang G, Li W. | 05/22/2021 |
| Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions. | Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions.
Jakovac H, Stašić N, Krašević M, Jonjić N, Radošević-Stašić B., Free PMC Article | 04/13/2021 |
| MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma. | MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma.
Mangelinck A, da Costa MEM, Stefanovska B, Bawa O, Polrot M, Gaspar N, Fromigué O., Free PMC Article | 10/24/2020 |
| Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels? | Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels?
Bilde K, Olesen RH, Ernst EH, Mamsen LS, Amoushahi M, Lykke-Hartmann K, Ernst E, Larsen A. | 10/3/2020 |
| Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers. | Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers.
Liu HL, Chuang HY, Hsu CN, Lee SS, Yang CC, Liu KT., Free PMC Article | 09/26/2020 |
| Metallothionein 2A (MT2A)/myeloid zinc-finger 1 (MZF1) may serve as a prognostic marker and a therapeutic target for human gastric cancer. | Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A.
Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang G, Chen K, He Y, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J. | 04/18/2020 |
| this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure. | Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions.
Shin CH, Lee MG, Han J, Jeong SI, Ryu BK, Chi SG., Free PMC Article | 05/19/2018 |
| There are evidence for implicating MT2A polymorphisms in the development of Sinonasal Inverted Papilloma. The findings also illustrate the key role played by the MT2A gene in inducing an aggressive Schneiderian Papilloma phenotype. | Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E. | 03/10/2018 |
| MT2A A-5G polymorphism may be associated with risk of developing chronic kidney disease and diabetes. | Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.
Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K., Free PMC Article | 01/20/2018 |
| Data suggest that genotype AA for SNP rs28366003 in MT2A is associated with higher blood zinc levels in subjects with diabetes type 2 (with chronic kidney disease) as compared to control subjects. This case-control, genetic association study was conducted in the Czech Republic. | Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease.
Raudenska M, Dvorakova V, Pacal L, Chalasova K, Kratochvilova M, Gumulec J, Ruttkay-Nedecky B, Zitka O, Kankova K, Adam V, Masarik M. | 12/30/2017 |
| We found a significant association of SNP rs28366003 at MT2A gene with susceptibility to the dry form of AMD in a Northern Spanish population. | Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration.
García M, Álvarez L, Fernández Á, González-Iglesias H, Escribano J, Fernández-Vega B, Villota E, Fernández-Vega Cueto L, Fernández-Vega Á, Coca-Prados M. | 12/2/2017 |
| Our results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased breast cancer risk in Northwest Chinese Han population. | Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population.
Liu D, Wang M, Tian T, Wang XJ, Kang HF, Jin TB, Zhang SQ, Guan HT, Yang PT, Liu K, Liu XH, Xu P, Zheng Y, Dai ZJ., Free PMC Article | 11/25/2017 |
| the association of the blood lead level and HDL-C may be modified by the MT2A genetic combination | The association of the blood lead level and serum lipid concentrations may be modified by the genetic combination of the metallothionein 2A polymorphisms rs10636 GC and rs28366003 AA.
Yang CC, Chuang CS, Lin CI, Wang CL, Huang YC, Chuang HY. | 10/28/2017 |
| The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes. | Zinc binds non-cooperatively to human liver metallothionein 2a at physiological pH.
Jayawardena DP, Heinemann IU, Stillman MJ. | 10/21/2017 |
| MT2A may be a chemosensitivity indicator in gastric cancer patients receiving docetaxel-based treatment. | Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation.
Pan Y, Lin S, Xing R, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J, Lu Y., Free PMC Article | 07/29/2017 |