| Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma. | Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma.
Lau HC, Yuan X, Huang H, Zhang M, Hsueh CY, Gong H., Free PMC Article | 10/30/2023 |
| Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Nakamura T, Koga-Ogawa Y, Fujimiya K, Chirifu M, Goto M, Ikemizu S, Nakabeppu Y, Yamagata Y. | 07/13/2023 |
| miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1. | miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1.
Zhang J, Liu R, Mo L, Liu C, Jiang J., Free PMC Article | 02/17/2023 |
| MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. | MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3.
Li J, Wang ZH, Dang YM, Li DN, Liu Z, Dai DP, Cai JP. | 07/23/2022 |
| Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer. | Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer.
Bialkowski K, Szpila A. | 12/11/2021 |
| Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. | Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma.
Oksvold MP, Berglund UW, Gad H, Bai B, Stokke T, Rein ID, Pham T, Sanjiv K, Øy GF, Norum JH, Smeland EB, Myklebust JH, Helleday T, Våtsveen TK., Free PMC Article | 10/16/2021 |
| A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis. | A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis.
Bialkowski K, Kasprzak KS. | 08/7/2021 |
| hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage. | hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
Arczewska KD, Krasuska W, Stachurska A, Karpińska K, Sikorska J, Kiedrowski M, Lange D, Stępień T, Czarnocka B. | 04/17/2021 |
| The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer. | The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.
Li DN, Yang CC, Li J, Ou Yang QG, Zeng LT, Fan GQ, Liu TH, Tian XY, Wang JJ, Zhang H, Dai DP, Cui J, Cai JP. | 04/17/2021 |
| Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension. | Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Vitry G, Paulin R, Grobs Y, Lampron MC, Shimauchi T, Lemay SE, Tremblay E, Habbout K, Awada C, Bourgeois A, Nadeau V, Paradis R, Breuils-Bonnet S, Roux-Dalvai F, Orcholski M, Potus F, Provencher S, Boucherat O, Bonnet S. | 04/13/2021 |
| Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1. | Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Chen H, Afrin S, Guo Y, Chu W, Benzinger TLS, Rogers BE, Garbow JR, Perlmutter JS, Zhou D, Xu J., Free PMC Article | 03/6/2021 |
| Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma. | Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma.
Ou Q, Ma N, Yu Z, Wang R, Hou Y, Wang Z, Chen F, Li W, Bi J, Ma J, Zhang L, Su Q, Huang X., Free PMC Article | 02/27/2021 |
| MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha. | MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha.
Bhavya B, Easwer HV, Vilanilam GC, Anand CR, Sreelakshmi K, Urulangodi M, Rajalakshmi P, Neena I, Padmakrishnan CJ, Menon GR, Krishnakumar K, Deepti AN, Gopala S. | 01/2/2021 |
| MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. | MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS., Free PMC Article | 12/19/2020 |
| The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway. | The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway.
Gul N, Karlsson J, Tängemo C, Linsefors S, Tuyizere S, Perkins R, Ala C, Zou Z, Larsson E, Bergö MO, Lindahl P., Free PMC Article | 10/31/2020 |
| [Proliferation-Inhibitory and Apoptosis-Inducing Effects of Targeting MTH1 on Multiple Myeloma Cells]. | [Proliferation-Inhibitory and Apoptosis-Inducing Effects of Targeting MTH1 on Multiple Myeloma Cells].
Wang X, Wu Y, Zhang L, Li YX, Han B, Shi X, Wang W, Wang LS. | 10/24/2020 |
| MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue | Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.
McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM., Free PMC Article | 05/23/2020 |
| NUDT1 expression was significantly increased in oral squamous cell carcinoma tissue and showed a strong association with histopathologic grades. Patients with high NUDT1 expression exhibited poorer overall survival rate and tumor-specific survival rate than those with low NUDT1 expression. | NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma.
Shen Y, Zhang L, Piao S, Li L, Li J, Xia Y, Li J, Saiyin W. | 04/4/2020 |
| NUDT1 protein conformation and substrate specificity revealed by X-ray crystallography. | Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P. | 11/30/2019 |
| Our results suggest that the contribution of NUDT1 and OGG1 germline mutations to hereditary colorectal cancer (CRC) and to polyposis is inexistent or, at most, negligible. The inclusion of these genes in routine genetic testing is not recommended. | Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.
Mur P, Jemth AS, Bevc L, Amaral N, Navarro M, Valdés-Mas R, Pons T, Aiza G, Urioste M, Valencia A, Lázaro C, Moreno V, Puente XS, Stenmark P, Warpman-Berglund U, Capellá G, Helleday T, Valle L. | 07/27/2019 |
| MTH1 is important for removal of methylated nucleotides from the nucleotide pool | MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T., Free PMC Article | 07/13/2019 |
| overall our cell viability data indicates that targeting MTH1 will likely not be an across-the-board effective non-small cell lung cancer therapeutic strategy; rather it induces non-cytotoxic DNA damage that could promote cancer heterogeneity and evolution. | MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?
Abbas HHK, Alhamoudi KMH, Evans MD, Jones GDD, Foster SS., Free PMC Article | 10/20/2018 |
| MTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells. | hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
Arczewska KD, Stachurska A, Wojewódzka M, Karpińska K, Kruszewski M, Nilsen H, Czarnocka B. | 10/13/2018 |
| PRDX1 and MTH1 cooperate to prevent accumulation of oxidized guanine in the genome | PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase.
Ahmed W, Lingner J., Free PMC Article | 07/14/2018 |
| Results provide evidence that MTH1 is not essential for cancer cell survival. | Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H., Free PMC Article | 05/26/2018 |