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    MTHFR methylenetetrahydrofolate reductase [ Homo sapiens (human) ]

    Gene ID: 4524, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case-control study.

    Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case-control study.
    Ren FJ, Fang GY, Zhang ZY., Free PMC Article

    11/1/2024
    Homozygous MTHFR C667T carriers </=45 years old develop central retinal vein occlusion five years earlier than wild type.

    Homozygous MTHFR C667T carriers ≤45 years old develop central retinal vein occlusion five years earlier than wild type.
    Ames PR, Arcaro A, D'Andrea G, Marottoli V, Iannaccone L, Maraglione M, Gentile F.

    10/30/2024
    Genetic association and computational analysis of MTHFR gene polymorphisms rs1801131 and rs1801133 with breast cancer in the Bangladeshi population.

    Genetic association and computational analysis of MTHFR gene polymorphisms rs1801131 and rs1801133 with breast cancer in the Bangladeshi population.
    Alam NF, Ahmed R, Mahmud Z, Tamanna S, Shaon MA, Howlader MZH., Free PMC Article

    10/25/2024
    The MTHFR C677T/A1298C polymorphism is associated with increased risk of microangiopathy in type 2 diabetes mellitus: A systematic review and meta-analysis.

    The MTHFR C677T/A1298C polymorphism is associated with increased risk of microangiopathy in type 2 diabetes mellitus: A systematic review and meta-analysis.
    Zhang Y, Zhang Y, Miao R, Fang X, Yin R, Guan H, Tian J.

    10/15/2024
    Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women.

    Epigenetic alterations in preeclampsia: a focus on microRNA149 and tetrahydrofolate reductase gene polymorphisms in Egyptian women.
    Ellakwa DE, Rashed LA, El-Mandoury AA, Younis NF.

    10/4/2024
    Association of Methylenetetrahydrofolate Reductase rs1801133 Polymorphism with osteoporosis and fracture risk in Taiwan.

    Association of Methylenetetrahydrofolate Reductase rs1801133 Polymorphism with osteoporosis and fracture risk in Taiwan.
    Li MH, Chen IC, Yang HW, Yen HC, Ke YY, Chen YM, Hsu CC., Free PMC Article

    10/1/2024
    Clinical characteristics and thrombophilia associated gene variants in Egyptians with unprovoked venous thromboembolism: three centers experience.

    Clinical characteristics and thrombophilia associated gene variants in Egyptians with unprovoked venous thromboembolism: three centers experience.
    Efat A, Shoeib S, Abdelmonem AA, Elamawy MM, Eleleimy HA, Ibrahem RA, Elmorshedy SM, Abdelaty MM.

    09/30/2024
    The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population.

    The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population.
    Liang Z, Li K, Chen H, Jia J, Li J, Huo Y, Fan F, Zhang Y., Free PMC Article

    09/25/2024
    The methylenetetrahydrofolate reductase C677T and A1298C genetic polymorphisms and plasma homocysteine in Alzheimer's disease in an Algerian population.

    The methylenetetrahydrofolate reductase C677T and A1298C genetic polymorphisms and plasma homocysteine in Alzheimer's disease in an Algerian population.
    Bouguerra K, Tazir M, Melouli H, Khelil M.

    09/10/2024
    MTHFR 677 C > T Gene Polymorphism is Associated with Large for Gestational Age Infants.

    MTHFR 677 C > T Gene Polymorphism is Associated with Large for Gestational Age Infants.
    Akcılar R, Yalınbaş EE, Mutlu F.

    08/30/2024
    SERPINE1 and MTHFR genetic variants in patients with embolic stroke of undetermined source: links with fibrin clot properties.

    SERPINE1 and MTHFR genetic variants in patients with embolic stroke of undetermined source: links with fibrin clot properties.
    Klajmon A, Ząbczyk M, Undas A, Natorska J.

    08/29/2024
    Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China.

    Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China.
    Yan J, Zhang Y, Zhou Y, Wan Y, Xiong H., Free PMC Article

    08/2/2024
    Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study.

    Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study.
    Pesqueda-Cendejas K, Parra-Rojas I, Campos-López B, Mora-García PE, Ruiz-Ballesteros AI, Rivera-Escoto M, Cerpa-Cruz S, De la Cruz-Mosso U.

    08/2/2024
    MTHFR gene polymorphisms in diabetes mellitus.

    MTHFR gene polymorphisms in diabetes mellitus.
    Cai Y, Liu B, Zhang Y, Zhou Y.

    07/31/2024
    Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic.

    Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic.
    Bai S, Li MZ, Wan YY, Hu XC, Liu YX, Tong XH, Guo TH, Zong L, Liu R, Zhao YQ, Xiang P, Xu B, Jiang XH., Free PMC Article

    07/25/2024
    Geographical distribution of MTHFR C677T gene polymorphisms among the reproductive-age women in Chinese Han populations: based on migration.

    Geographical distribution of MTHFR C677T gene polymorphisms among the reproductive-age women in Chinese Han populations: based on migration.
    Shen Y, Gu Y, Tang Y, Shen H, Liu C., Free PMC Article

    07/23/2024
    Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case-Control Study.

    Association of Maternal Dietary Habits and Infant MTHFR Gene Polymorphisms with Ventricular Septal Defect in Offspring: A Case-Control Study.
    Ruan X, Li Z, Zhong T, Lei R, Luo M, Sun M, Qin J., Free PMC Article

    07/18/2024
    [Analysis of MTHFR gene variants in fifteen children with hyperhomocysteinemia].

    [Analysis of MTHFR gene variants in fifteen children with hyperhomocysteinemia].
    Liu F, Liang LL, Qiu WJ, Zhang HW, Zhan X, Xu F, Zhang Y, Zhang JM, Yang SH, Han LS.

    07/9/2024
    Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.

    Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.
    Huang Y, Su T, Duan Q, Wei X, Fan X, Wan J, Liu L, Dian Z, Zhang G, Sun Y, Zhou T, Xu Y., Free PMC Article

    06/28/2024
    MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.

    MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.
    Romero-Bolaño YM, Bobadilla-Morales L, Corona-Rivera A, Cuero-Quezada I, Santana-Hernández J, Peña-Padilla C, Brukman-Jiménez A, Orozco-Vela M, Navia-Espinoza N, Corona-Rivera JR.

    06/12/2024
    Retrospective cohort study of the MTHFR C677T/A1298C polymorphisms and human homocysteine levels in Helicobacter pylori infection.

    Retrospective cohort study of the MTHFR C677T/A1298C polymorphisms and human homocysteine levels in Helicobacter pylori infection.
    Oliveira APG, de Matos GCB, Vieira MCDS, Corvelo TCO.

    06/3/2024
    Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome.

    Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome.
    Zhao J, Li X, Chen Q.

    05/29/2024
    Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention.

    Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention.
    Shi Y, Zhang Z, Wang B, Wang Y, Kong X, Sun Y, Li A, Cui Y, Zhang Y, Li J, Huo Y, Huang H., Free PMC Article

    05/13/2024
    Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects.

    Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects.
    Nasri K, Ben Jamaa N, Gaigi SS, Feki M, Marrakchi R.

    05/9/2024
    Homozygous MTHFR C677T carriers develop idiopathic portal vein thrombosis 20 years earlier than wild type.

    Homozygous MTHFR C677T carriers develop idiopathic portal vein thrombosis 20 years earlier than wild type.
    Ames PR, D'Andrea G, Arcaro A, Marottoli V, Iannaccone L, Margaglione M, Gentile F.

    05/9/2024
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