| A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling. | A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling.
Xiong S, Li S, Li Z, Song Y, Yang L, Yang H, Xiong J, Pan W, Guo J, Fu B, Xu S. | 09/4/2024 |
| Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease. | Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease.
Elmubarak I, Shril S, Mansour B, Bao A, Kolvenbach CM, Kari JA, Shalaby MA, El Desoky S, Hildebrandt F, Schneider R. | 08/28/2024 |
| RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C. | RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C.
Suo J, Wang Y, Wang L, Qiu B, Wang Z, Yan A, Qiang B, Han W, Peng X., Free PMC Article | 01/9/2024 |
| Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19. | Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19.
Kit Y, Starykovych M, Manko N, Orfin A, Alexanyan T, Bozhko L, Turchyna T, Kit O, Krishnankutty R, Anand A, Sibirny A, Souchelnytskyi S, Stoika R., Free PMC Article | 03/8/2023 |
| m[6]A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m[6]A/PD-L1 manner. | m(6)A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m(6)A/PD-L1 manner.
Guan H, Tian K, Luo W, Li M., Free PMC Article | 02/16/2023 |
| SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line. | SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.
Di Pisa F, Pesenti E, Bono M, Mazzarello AN, Bernardi C, Lisanti MP, Renzone G, Scaloni A, Ciccone E, Fais F, Bruno S, Scartezzini P, Ghiotto F., Free PMC Article | 01/1/2022 |
| Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer. | Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer.
Saidova AA, Potashnikova DM, Tvorogova AV, Paklina OV, Veliev EI, Knyshinsky GV, Setdikova GR, Rotin DL, Maly IV, Hofmann WA, Vorobjev IA., Free PMC Article | 10/23/2021 |
| Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value. | Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value.
Starykovych M, Antonyuk V, Nehrych T, Negrych N, Horák D, Souchelnytskyi S, Kit O, Stoika R, Kit Y. | 07/3/2021 |
| MYO1C stabilizes actin at the Golgi complex, facilitating the arrival of incoming transport carriers at the Golgi. | MYO1C stabilizes actin and facilitates the arrival of transport carriers at the Golgi complex.
Capmany A, Yoshimura A, Kerdous R, Caorsi V, Lescure A, Del Nery E, Coudrier E, Goud B, Schauer K. | 07/4/2020 |
| E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. | Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication.
Sankovski E, Abroi A, Ustav M Jr, Ustav M. | 05/26/2018 |
| The results establish a mechanistic connection between the calcium regulation of the motor function of myosin IC in the cytoplasm and the induction of its import into the nucleus. | Calcium-regulated import of myosin IC into the nucleus.
Maly IV, Hofmann WA. | 11/26/2017 |
| NTR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior. Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding to their kinetic diversity. We propose that this level of fine-tuning within MYO1C broadens its adaptability within cells. | N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.
Zattelman L, Regev R, Ušaj M, Reinke PYA, Giese S, Samson AO, Taft MH, Manstein DJ, Henn A., Free PMC Article | 11/4/2017 |
| Cells expressing excess of MYO1C had low basal level of phosphorylated protein kinase B. | Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT.
Visuttijai K, Pettersson J, Mehrbani Azar Y, van den Bout I, Örndal C, Marcickiewicz J, Nilsson S, Hörnquist M, Olsson B, Ejeskär K, Behboudi A., Free PMC Article | 06/24/2017 |
| Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1) ensues, which appears to be functionally linked to Upsilon-H2AX signaling. | Chromosome territory relocation during DNA repair requires nuclear myosin 1 recruitment to chromatin mediated by ϒ-H2AX signaling.
Kulashreshtha M, Mehta IS, Kumar P, Rao BJ., Free PMC Article | 06/10/2017 |
| Study presents structural demonstration of a cargo protein, Neph1, attached to Myo1c, providing novel insights into the role of Myo1c in intracellular movements of this critical slit diaphragm protein. | Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1.
Arif E, Sharma P, Solanki A, Mallik L, Rathore YS, Twal WO, Nath SK, Gandhi D, Holzman LB, Ostap EM, Ashish, Nihalani D., Free PMC Article | 05/27/2017 |
| In glioblastoma 1321 N1 cells, we recently identified Myo1c as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c depleted cells. In the absence of Myo1c, N1 cells tend to associate to form clusters. | The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells.
Edimo WE, Ramos AR, Ghosh S, Vanderwinden JM, Erneux C. | 05/27/2017 |
| Overexpression of MYO1C is associated with gastric cancer. | miR-137 plays tumor suppressor roles in gastric cancer cell lines by targeting KLF12 and MYO1C.
Du Y, Chen Y, Wang F, Gu L. | 02/18/2017 |
| Ablating MYO1C function causes abnormal cholesterol distribution, which has a major selective impact on the autophagy pathway | Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.
Brandstaetter H, Kishi-Itakura C, Tumbarello DA, Manstein DJ, Buss F., Free PMC Article | 12/12/2015 |
| Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination. | Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.
McIntosh BB, Holzbaur EL, Ostap EM., Free PMC Article | 12/5/2015 |
| NM1 phosphorylation by GSK3beta blocks NM1 ubiquitination by UBR5 and degradation by the proteasome, leads to NM1 association with the chromatin and promotes rDNA transcription activation at G1. | Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells.
Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P., Free PMC Article | 06/27/2015 |
| The relationship between MYO1C and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1) function of MYO1C. | Molecular motor MYO1C, acetyltransferase KAT6B and osteogenetic transcription factor RUNX2 expression in human masseter muscle contributes to development of malocclusion.
Desh H, Gray SL, Horton MJ, Raoul G, Rowlerson AM, Ferri J, Vieira AR, Sciote JJ., Free PMC Article | 01/17/2015 |
| myosin 1c manipulations lead to loss of the actin filaments and to similar endoplasmic reticulum phenotype as observed after actin depolymerization. | ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays.
Joensuu M, Belevich I, Rämö O, Nevzorov I, Vihinen H, Puhka M, Witkos TM, Lowe M, Vartiainen MK, Jokitalo E., Free PMC Article | 11/29/2014 |
| The structural context and the chemical environment of Myo1c mutations that are involved in sensorineural hearing loss in humans are described and their impact on motor function is discussed. | Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.
Münnich S, Taft MH, Manstein DJ. | 07/5/2014 |
| These results suggest a unique structural role for NM1 in which the interaction with SNF2h stabilizes B-WICH at the gene promoter and facilitates recruitment of the HAT PCAF | Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.
Sarshad A, Sadeghifar F, Louvet E, Mori R, Böhm S, Al-Muzzaini B, Vintermist A, Fomproix N, Östlund AK, Percipalle P., Free PMC Article | 06/29/2013 |
| Both nucleolar localization signals are functional and necessary for nucleolar localization of specifically myosin IC isoform B. | Identification of signals that facilitate isoform specific nucleolar localization of myosin IC.
Schwab RS, Ihnatovych I, Yunus SZ, Domaradzki T, Hofmann WA. | 06/15/2013 |