| The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-alpha. | The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF-α.
Song D, Peng K, Palmer BE, Lee FS., Free PMC Article | 11/29/2022 |
| These results suggest that PP1A dephosphorylates NACA at specific residues, impacting cJUN transcriptional activity and osteoblast differentiation and function. | Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation.
Addison WN, Pellicelli M, St-Arnaud R., Free PMC Article | 12/14/2019 |
| NAC is a potent suppressor of aggregation and proteotoxicity of mutant PolyQ-expanded proteins associated with human diseases like Huntington's disease and spinocerebellar ataxias. | Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies.
Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlömer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E., Free PMC Article | 10/19/2019 |
| depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway. | αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells.
Zeng W, Zhang J, Qi M, Peng C, Su J, Chen X, Yuan Z., Free PMC Article | 02/14/2015 |
| Low NACA expression is associated with rhabdomyosarcoma. | Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading.
Berkholz J, Kuzyniak W, Hoepfner M, Munz B. | 02/14/2015 |
| [review] First evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha). | Combinatorial control of ATF4-dependent gene transcription in osteoblasts.
St-Arnaud R, Hekmatnejad B., Free PMC Article | 01/7/2012 |
| NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. | Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, Cengiz B, Gogebakan B, Cakmak EA, Demiryurek AT. | 04/26/2011 |
| identified a region in the NAC domain of the human NAC alpha-subunit as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit | The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit .
Liu Y, Hu Y, Li X, Niu L, Teng M. | 05/31/2010 |
| Alpha NAC downregulation in hypoxic cells or NAC ablation by NAC short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase-dependent apoptosis. | alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia.
Hotokezaka Y, van Leyen K, Lo EH, Beatrix B, Katayama I, Jin G, Nakamura T. | 01/21/2010 |
| A 220 kDa isoform of Naca is expressed in mouse muscle tissues | Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factor.
Yotov WV, St-Arnaud R. | 12/28/2007 |
| Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome. | Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.
Kim SH, Shim KS, Lubec G. | 01/21/2010 |
| virtual Northern blots to analyze expression of NACA and ANX2 in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals | Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.
Hämmerle K, Shayan P, Niemeyer CM, Flotho C. | 01/21/2010 |
| Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation. | NACA is a positive regulator of human erythroid-cell differentiation.
Lopez S, Stuhl L, Fichelson S, Dubart-Kupperschmitt A, St Arnaud R, Galindo JR, Murati A, Berda N, Dubreuil P, Gomez S. | 01/21/2010 |
| a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen | Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.
Mossabeb R, Seiberler S, Mittermann I, Reininger R, Spitzauer S, Natter S, Verdino P, Keller W, Kraft D, Valenta R. | 01/21/2010 |