| Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p. | Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p.
He P, Liu Z, Qi J, Shan J, Sheng J., Free PMC Article | 02/2/2024 |
| Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells. | Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells.
Nuiyen A, Rattanasri A, Wipa P, Roytrakul S, Wangteeraprasert A, Pongcharoen S, Ngoenkam J., Free PMC Article | 08/6/2022 |
| LncRNA NCK1-AS1 Promotes Malignant Cellular Phenotypes of Laryngeal Squamous Cell Carcinoma via miR-137/NCK1 Axis. | LncRNA NCK1-AS1 Promotes Malignant Cellular Phenotypes of Laryngeal Squamous Cell Carcinoma via miR-137/NCK1 Axis.
Wan L, Gu D, Jin X. | 07/16/2022 |
| STAT3-induced NCK1 elevation promotes migration of triple-negative breast cancer cells via regulating ERK1/2 signaling. | STAT3-induced NCK1 elevation promotes migration of triple-negative breast cancer cells via regulating ERK1/2 signaling.
He P, Sheng J, Qi J, Bai X, Li J, Wang F, Yuan Y, Zheng X. | 03/26/2022 |
| NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC. | NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.
Zhou X, Bao W, Zhang D, Yang Y, Du X, Qiu G., Free PMC Article | 01/1/2022 |
| Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling. | Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.
Hartl FA, Ngoenkam J, Beck-Garcia E, Cerqueira L, Wipa P, Paensuwan P, Suriyaphol P, Mishra P, Schraven B, Günther S, Pongcharoen S, Schamel WWA, Minguet S., Free PMC Article | 10/23/2021 |
| LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/beta-catenin signaling. | LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling.
Guan B, Ma J, Yang Z, Yu F, Yao J. | 08/21/2021 |
| Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. | Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Alfaidi M, Bhattarai U, Orr AW., Free PMC Article | 03/13/2021 |
| Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents. | Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents.
Eduardo da Silva L, Russo LC, Forti FL. | 03/6/2021 |
| Selective role of Nck1 in atherogenic inflammation and plaque formation. | Selective role of Nck1 in atherogenic inflammation and plaque formation.
Alfaidi M, Acosta CH, Wang D, Traylor JG, Orr AW., Free PMC Article | 02/6/2021 |
| SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells. | SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells.
Pauls SD, Hou S, Marshall AJ. | 12/26/2020 |
| Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion. | Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.
Chaki SP, Barhoumi R, Rivera GM., Free PMC Article | 09/26/2020 |
| NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer. | NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
Chang H, Li B, Zhang X, Meng X. | 08/15/2020 |
| Together, these data support a model wherein TNK2, WASL, and NCK1 comprise a pathway important for the entry of multiple picornaviruses. | Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1.
Jiang H, Leung C, Tahan S, Wang D., Free PMC Article | 05/9/2020 |
| Actin polymerization promotes the recruitment of Nck to the TCR, enhancing downstream signaling, such as phosphorylation of CD3epsilon and lymphocyte activation. | Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.
Wipa P, Paensuwan P, Ngoenkam J, Woessner NM, Minguet S, Schamel WW, Pongcharoen S., Free PMC Article | 05/2/2020 |
| Study finds Nck1 RNA and protein was upregulated significantly in high grade astrocytoma tissues as compared to low grade and control tissue samples. Nck1 appears as possible biomarker for astrocytoma progression and may serve as an important therapeutic target. | Expression and clinicopathological significance of Nck1 in human astrocytoma progression.
Deshpande RP, Panigrahi M, Y B V K CS, Babu PP. | 04/27/2019 |
| Nck1 level gradually increased from normal cervical epithelia to high-grade CIN, overexpressed in CSCC and was associated with cancer MVD. | NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
Xia P, Huang M, Zhang Y, Xiong X, Yan M, Xiong X, Yu W, Song E. | 02/23/2019 |
| There was no difference in the Nck1 mRNA expression between the SLE patients and the healthy subjects. | A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.
Towiwat P, Buttham B. | 07/14/2018 |
| These findings suggest a novel STAT3 to NCK1 to PAK1/ERK signaling mechanism that is potentially critical for colorectal cancer metastasis and angiogenesis. | Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Zhang F, Lu YX, Chen Q, Zou HM, Zhang JM, Hu YH, Li XM, Zhang WJ, Zhang W, Lin C, Li XN. | 03/10/2018 |
| this study highlights an important role for Nck1 in fine-tuning IRE1alpha expression and signaling that regulate PTP1B expression and subsequent activation of the PI3K-Akt pathway in HepG2 cells. | IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells.
Li H, Li B, Larose L. | 03/10/2018 |
| Authors provide evidence that Nck is an upstream regulator of RhoA-dependent, MMP14-mediated breast carcinoma cell invasion. | Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis.
Morris DC, Popp JL, Tang LK, Gibbs HC, Schmitt E, Chaki SP, Bywaters BC, Yeh AT, Porter WW, Burghardt RC, Barhoumi R, Rivera GM., Free PMC Article | 01/20/2018 |
| Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. | Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.
Keyvani Chahi A, Martin CE, Jones N., Free PMC Article | 11/12/2016 |
| Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation. | Actin remodeling by Nck regulates endothelial lumen formation.
Chaki SP, Barhoumi R, Rivera GM., Free PMC Article | 06/11/2016 |
| the binding of Nck to the TCR requires partial phosphorylation of CD3epsilon, as it is based on two cooperating interactions. | Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.
Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S. | 05/21/2016 |
| Nck was the most potent activator of N-WASP-driven actin assembly. | Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J., Free PMC Article | 03/19/2016 |