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    NFATC2 nuclear factor of activated T cells 2 [ Homo sapiens (human) ]

    Gene ID: 4773, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.

    STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.
    Hammad AS, Yu F, Al-Hamaq J, Horgen FD, Machaca K.

    10/1/2024
    The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.

    The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma.
    Xiao ZJ, Wang SQ, Chen JJ, Li Y, Jiang Y, Tin VP, Liu J, Hu H, Wong MP, Pan Y, Yam JWP., Free PMC Article

    07/5/2024
    The RNA m[6]A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.

    The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.
    Ge L, Rui Y, Wang C, Wu Y, Wang H, Wang J., Free PMC Article

    03/12/2024
    Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.

    Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.
    Liu L, Li L, Ding Y, Kong F, Mo W, Ye H, Shen D., Free PMC Article

    02/12/2024
    Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.

    Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
    Vittal R, Walker NM, McLinden AP, Braeuer RR, Ke F, Fattahi F, Combs MP, Misumi K, Aoki Y, Wheeler DS, Wilke CA, Huang SK, Moore BB, Cao P, Lama VN.,

    01/7/2024
    Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.

    Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the Proliferation and Migration Behavior of Pancreatic Cancer Cells.
    Malsy M, Graf B, Bruendl E, Maier-Stocker C, Bundscherer A., Free PMC Article

    12/5/2023
    Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.

    Over-expression of cFos by the Transcription Factors NFATc2 and Sp1 in Pancreatic Cancer Cells.
    Malsy M, Graf B, Bruendl E, Maier-Stocker C, Bundscherer A.

    11/3/2023
    NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells.

    NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
    Shim JA, Lee SM, Jeong JW, Kim H, Son WJ, Park JH, Song P, Im SH, Bae S, Park JH, Jo Y, Hong C., Free PMC Article

    11/3/2023
    Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.

    Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
    Zhao W, Zhao J, Li K, Hu Y, Yang D, Tan B, Shi J.

    09/25/2023
    Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.

    Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
    Miao Y, Qian G, Zhang R, Yuan Y, Zuo Y, Ding Y, Li X, Tang Y, Zheng H, Lv H.

    09/13/2023
    No NFATC2 fusion in simple bone cyst of the jaw.

    No NFATC2 fusion in simple bone cyst of the jaw.
    Ong SLM, Gomes IP, Baelde HJ, Passador-Santos F, de Andrade BAB, Briaire-de Bruijn IH, Cavalcante IL, Schreuder WH, Cleton-Jansen AM, Cleven AHG, Szuhai K, Gomes CC, Bovée JVMG.

    07/24/2023
    PARP1 Is a Prognostic Marker and Targets NFATc2 to Promote Carcinogenesis in Melanoma.

    PARP1 Is a Prognostic Marker and Targets NFATc2 to Promote Carcinogenesis in Melanoma.
    Mou K, Zhou Y, Mu X, Zhang J, Wang L, Ge R.

    12/3/2022
    Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy.

    Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy.
    Sharma M, Fu MP, Lu HY, Sharma AA, Modi BP, Michalski C, Lin S, Dalmann J, Salman A, Del Bel KL, Waqas M, Terry J, Setiadi A, Lavoie PM, Wasserman WW, Mwenifumbo J, Kobor MS, Lee AF, Kuchenbauer F, Lehman A, Cheng S, Cooper A, Patel MS, Turvey SE.

    11/5/2022
    Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.

    Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
    Ni L, Lahiri SK, Nie J, Pan X, Abu-Taha I, Reynolds JO, Campbell HM, Wang H, Kamler M, Schmitz W, Müller FU, Li N, Wei X, Wang DW, Dobrev D, Wehrens XHT., Free PMC Article

    10/29/2022
    STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-beta1 pathway.

    STIM2 promotes the invasion and metastasis of breast cancer cells through the NFAT1/TGF-β1 pathway.
    Cheng H, Chen L, Fang Z, Wan Q, Du Z, Ma N, Guo G, Lu W.

    07/16/2022
    Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1beta-dependent response of Th17 cells.

    Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells.
    Kim DH, Kim HY, Cho S, Yoo SJ, Kim WJ, Yeon HR, Choi K, Choi JM, Kang SW, Lee WW., Free PMC Article

    02/5/2022
    TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3beta/NFATc2 signaling pathway.

    TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.
    Lin DC, Zheng SY, Zhang ZG, Luo JH, Zhu ZL, Li L, Chen LS, Lin X, Sham JSK, Lin MJ, Zhou RX.

    01/8/2022
    Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis.

    Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis.
    Imani SZH, Hojati Z, Khalilian S, Dehghanian F, Kheirollahi M, Khorrami M, Shaygannejad V, Mirmosayyeb O., Free PMC Article

    01/1/2022
    The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry.

    The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry.
    Kar P, Lin YP, Bhardwaj R, Tucker CJ, Bird GS, Hediger MA, Monico C, Amin N, Parekh AB., Free PMC Article

    12/11/2021
    Identification of direct transcriptional targets of NFATC2 that promote beta cell proliferation.

    Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
    Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD., Free PMC Article

    12/11/2021
    Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst.

    Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst.
    Ong SLM, Lam SW, van den Akker BEWM, Kroon HM, Briaire-de Bruijn IH, Cleven AHG, Savci-Heijink DC, Cleton-Jansen AM, Baumhoer D, Szuhai K, Bovée JVMG., Free PMC Article

    12/4/2021
    NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator.

    NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator.
    Muramatsu M, Ito T, Shimoji H, Komiya M, Miyamura Y, Nishiyama K, Suzuki T, Minami T.

    11/22/2021
    The role of molecular diagnostics in aneurysmal and simple bone cysts - a prospective analysis of 19 lesions.

    The role of molecular diagnostics in aneurysmal and simple bone cysts - a prospective analysis of 19 lesions.
    Pižem J, Šekoranja D, Matjašič A, Zupan A, Boštjančič E, Limpel Novak KA, Salapura V, Mavčič B, Gazič B, Dimnik K.

    10/30/2021
    Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma.

    Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma.
    Jakobi M, Kiefer A, Mirzakhani H, Rauh M, Zimmermann T, Xepapadaki P, Stanic B, Akdis M, Papadopoulos NG, Raby BA, Weiss ST, Finotto S., Free PMC Article

    09/25/2021
    FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells.

    FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells.
    Wang J, Zhao H, Zheng L, Zhou Y, Wu L, Xu Y, Zhang X, Yan G, Sheng H, Xin R, Jiang L, Lei J, Zhang J, Chen Y, Peng J, Chen Q, Yang S, Yu K, Li D, Xie Q, Li Y., Free PMC Article

    08/7/2021
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