| CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions. | CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions.
Tauziède-Espariat A, Lew-Derivry L, Abbou S, Métais A, Pierron G, Reynaud S, Masliah-Planchon J, Mariet C, Hasty L, Dangouloff-Ros V, Boddaert N, Csanyi M, Aline-Fardin A, Lamaison C, Chrétien F, Beccaria K, Puget S, Varlet P., Free PMC Article | 02/1/2024 |
| Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity. | Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity.
Kong S, Chen TX, Jia XL, Cheng XL, Zeng ML, Liang JY, He XH, Yin J, Han S, Liu WH, Fan YT, Zhou T, Liu YM, Peng BW., Free PMC Article | 11/14/2023 |
| SOX9/NFIA promotes human ovarian cancer metastasis through the Wnt/beta-catenin signaling pathway. | SOX9/NFIA promotes human ovarian cancer metastasis through the Wnt/β-catenin signaling pathway.
Lu R, Tang P, Zhang D, Lin S, Li H, Feng X, Sun M, Zhang H. | 08/20/2023 |
| Spatial control of astrogenesis progression by cortical arealization genes. | Spatial control of astrogenesis progression by cortical arealization genes.
Santo M, Rigoldi L, Falcone C, Tuccillo M, Calabrese M, Martínez-Cerdeño V, Mallamaci A. | 03/21/2023 |
| HIF-1alpha and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes. | HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes.
Malczewska-Lenczowska J, Orysiak J, Majorczyk E, Sitkowski D, Starczewski M, Żmijewski P. | 06/18/2022 |
| The miR-223/nuclear factor I-A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis. | The miR-223/nuclear factor I-A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis.
Wu YZ, Chan KYY, Leung KT, Lam HS, Tam YH, Lee KH, Li K, Ng PC., Free PMC Article | 04/9/2022 |
| Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers. | Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers.
Kaczorowski M, Matysiak J, Kielb P, Malkiewicz B, Halon A. | 01/15/2022 |
| Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles. | Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.
Uehara T, Sanuki R, Ogura Y, Yokoyama A, Yoshida T, Futagawa H, Yoshihashi H, Yamada M, Suzuki H, Takenouchi T, Matsubara K, Hirata H, Kosaki K, Takano-Shimizu T., Free PMC Article | 01/8/2022 |
| Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease. | Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.
Kim BH, Nho K, Lee JM, Alzheimer's Disease Neuroimaging Initiative. | 12/11/2021 |
| NFIA enhances cell radiosensitivity by downregulating p-AKT and p-ERK in non-small cell lung cancer | A novel role for NFIA in restoring radiosensitivity in radioresistant NSCLC cells by downregulating the AKT and ERK pathways.
Sun C, Li Y, Tan Y, Zhang H, Liang Y, Zeng J, Yu J, Zou H. | 07/11/2020 |
| NFIA is highly expressed in reactive astrocytes in neurological injury and we identify unique roles across distinct injury states and regions of the CNS. | Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury.
Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B., Free PMC Article | 06/13/2020 |
| Low expression of NFIA is associated with high-grade glioblastoma. | Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.
Chen KS, Bridges CR, Lynton Z, Lim JWC, Stringer BW, Rajagopal R, Wong KT, Ganesan D, Ariffin H, Day BW, Richards LJ, Bunt J. | 06/13/2020 |
| our results indicated that miR-212-3p targeting NFIA might serve as a promising target for bladder cancer (BC) | MiR-212-3p inhibits cell proliferation and promotes apoptosis by targeting nuclear factor IA in bladder cancer.
Wu X, Chen H, Zhang G, Wu J, Zhu W, Gu Y, He YI. | 02/1/2020 |
| This study reveals NFIA as a pro-endocrine factor in the pancreas, acting to repress Mib1, inhibit Dll1 endocytosis and thus promote escape from Notch activation. | Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.
Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M. | 12/7/2019 |
| High Nuclear factor I A expresion is associated with temozolomide resistance in glioblastoma via activation of nuclear factor kappaB pathway. | Nuclear factor I A promotes temozolomide resistance in glioblastoma via activation of nuclear factor κB pathway.
Yu X, Wang M, Zuo J, Wahafu A, Mao P, Li R, Wu W, Xie W, Wang J. | 11/9/2019 |
| High NFIA expression in tumors of patients with esophageal squamous cell carcinoma (ESCC) is correlated with lymph node metastasis and poor differentiation. NFIA is found to be an independent predictor of poor prognosis in patients with ESCC. | Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma.
Yang B, Zhou ZH, Chen L, Cui X, Hou JY, Fan KJ, Han SH, Li P, Yi SQ, Liu Y., Free PMC Article | 09/7/2019 |
| Transient expression of NFIA is sufficient to trigger glial competency of human pluripotent stem cell-derived neural stem cells within 5 days and to convert these cells into astrocytes in the presence of glial-promoting factors, as compared to 3-6 months using current protocols. | NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.
Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L., Free PMC Article | 04/6/2019 |
| The consistent overlap in clinical presentation provides further evidence of the critical role of NFIA haploinsufficiency in the development of the 1p32-p31 microdeletion syndrome phenotype. | Loss-of-function variants in NFIA provide further support that NFIA is a critical gene in 1p32-p31 deletion syndrome: A four patient series.
Revah-Politi A, Ganapathi M, Bier L, Cho MT, Goldstein DB, Hemati P, Iglesias A, Juusola J, Pappas J, Petrovski S, Wilson AL, Aggarwal VS, Anyane-Yeboa K. | 03/24/2018 |
| Data define a previously unknown nuclear factor I-A-nuclear factor-kappaB feed-forward regulation that may contribute to glioblastoma cell survival. | A novel NFIA-NFκB feed-forward loop contributes to glioblastoma cell survival.
Lee J, Hoxha E, Song HR., Free PMC Article | 12/23/2017 |
| Studies indicate the role of nuclear factor one (NFIs) as epigenetic regulators in cancer. | Nuclear factor one transcription factors as epigenetic regulators in cancer.
Fane M, Harris L, Smith AG, Piper M. | 09/23/2017 |
| Altogether, these results demonstrated that miR-370 suppressed hepatitis B virus gene expression and replication through repressing NFIA expression, which stimulates hepatitis B virus replication via direct regulation on hepatitis B virus Enhancer I activities. | miR-370 suppresses HBV gene expression and replication by targeting nuclear factor IA.
Fan H, Lv P, Lv J, Zhao X, Liu M, Zhang G, Tang H. | 09/9/2017 |
| We verified that NFIA binds to the IGFBP2 promoter and transcriptionally enhances IGFBP2 expression levels. We identified that NFIA-mediated IGFBP2 signaling pathways are involved in miR-302b-induced glioma cell death. | The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA.
Lee CC, Chen PH, Ho KH, Shih CM, Cheng CH, Lin CW, Cheng KT, Liu AJ, Chen KC., Free PMC Article | 08/26/2017 |
| miR-191 was upregulated in patients with middle- and late-stage NSCLC, and in NSCLC cell lines, under mild hypoxic conditions. miR-191 promoted the proliferation and migration of NSCLC under chronic hypoxic conditions, and this promotion may be associated with its targeting of NFIA. | A novel pathway in NSCLC cells: miR‑191, targeting NFIA, is induced by chronic hypoxia, and promotes cell proliferation and migration.
Zhao J, Qiao CR, Ding Z, Sheng YL, Li XN, Yang Y, Zhu DY, Zhang CY, Liu DL, Wu K, Zhao S. | 07/15/2017 |
| Dihydrocapsaicin can significantly decrease proinflammatory cytokines through enhancing NFIA and inhibiting NF-kappaB expression | Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner.
Zhao JJ, Hu YW, Huang C, Ma X, Kang CM, Zhang Y, Guo FX, Lu JB, Xiu JC, Qiu YR, Sha YH, Gao JJ, Wang YC, Li P, Xu BM, Zheng L, Wang Q. | 05/13/2017 |
| These results demonstrated that RP5833A20.1 inhibited tumor cell proliferation, induced apoptosis and inhibited cellcycle progression by suppressing the expression of NFIA in U251 cells. | Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells.
Kang CM, Hu YW, Nie Y, Zhao JY, Li SF, Chu S, Li HX, Huang QS, Qiu YR. | 04/8/2017 |