| The multifaceted functions of NFE2L1 in metabolism and associated disorders. | The multifaceted functions of NFE2L1 in metabolism and associated disorders.
Zhao X, Xu C, Ding Y, Yan N. | 07/30/2024 |
| Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy. | Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy.
Ward MA, Vangala JR, Kamber Kaya HE, Byers HA, Hosseini N, Diaz A, Cuervo AM, Kaushik S, Radhakrishnan SK., Free PMC Article | 05/3/2024 |
| Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate. | Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Deng R, Zheng Z, Hu S, Wang M, Feng J, Mattjus P, Zhang Z, Zhang Y. | 02/6/2024 |
| Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells. | Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells.
Liu K, Hu S, Qiu L, Wang M, Zhang Z, Sun G, Zhang Y., Free PMC Article | 12/21/2023 |
| NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma. | NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.
Zhang M, Wang Z, Yang G, Han L, Wang X. | 11/30/2023 |
| Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer. | Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.
Byers HA, Brooks AN, Vangala JR, Grible JM, Feygin A, Clevenger CV, Harrell JC, Radhakrishnan SK., Free PMC Article | 10/12/2023 |
| Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage. | Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage.
Elshani M, Um IH, Leung S, Reynolds PA, Chapman A, Kudsy M, Harrison DJ., Free PMC Article | 09/22/2023 |
| The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis. | The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.
Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A., Free PMC Article | 09/7/2023 |
| Unravelling the role of NFE2L1 in stress responses and related diseases. | Unravelling the role of NFE2L1 in stress responses and related diseases.
Liu X, Xu C, Xiao W, Yan N., Free PMC Article | 08/25/2023 |
| The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells. | The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells.
Oroń M, Grochowski M, Jaiswar A, Legierska J, Jastrzębski K, Nowak-Niezgoda M, Kołos M, Kaźmierczak W, Olesiński T, Lenarcik M, Cybulska M, Mikula M, Żylicz A, Miączyńska M, Zettl K, Wiśniewski JR, Walerych D. | 10/29/2022 |
| Ferroptosis regulation by the NGLY1/NFE2L1 pathway. | Ferroptosis regulation by the NGLY1/NFE2L1 pathway.
Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ., Free PMC Article | 05/14/2022 |
| Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival. | Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival.
Chen T, Ho M, Briere J, Moscvin M, Czarnecki PG, Anderson KC, Blackwell TK, Bianchi G., Free PMC Article | 04/30/2022 |
| Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28/I2 chondrocytes. | Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28/I2 chondrocytes.
Zhang S, Luo J, Zeng S. | 04/30/2022 |
| Feedback regulation of antioxidant transcription factor NFE2L1 and immunostimulatory factor 41BBL mediates the crosstalk between oxidative stress and tumor immunity. | Feedback regulation of antioxidant transcription factor NFE2L1 and immunostimulatory factor 41BBL mediates the crosstalk between oxidative stress and tumor immunity.
Qiu L, Ning H, Zhu Y, Yang Q, Liu L, Luo L, Gao Y, Xing Y. | 02/26/2022 |
| CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2. | CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.
Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H. | 09/25/2021 |
| Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. | Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN., Free PMC Article | 09/25/2021 |
| The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure. | The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure.
Han JJW, Ho DV, Kim HM, Lee JY, Jeon YS, Chan JY., Free PMC Article | 09/18/2021 |
| Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks. | Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks.
Zhang S, Deng Y, Xiang Y, Hu S, Qiu L, Zhang Y., Free PMC Article | 09/11/2021 |
| Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration. | Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration.
Northrop A, Byers HA, Radhakrishnan SK., Free PMC Article | 06/26/2021 |
| Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. | Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Wang S, Cheng H, Wang L, Zhao R, Guan D., Free PMC Article | 12/26/2020 |
| Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genes. | Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genes.
Wang M, Qiu L, Ru X, Song Y, Zhang Y., Free PMC Article | 10/24/2020 |
| DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1. | DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1.
Dirac-Svejstrup AB, Walker J, Faull P, Encheva V, Akimov V, Puglia M, Perkins D, Kümper S, Hunjan SS, Blagoev B, Snijders AP, Powell DJ, Svejstrup JQ., Free PMC Article | 09/5/2020 |
| NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression. | NFE2L1 and NFE2L3 Complementarily Maintain Basal Proteasome Activity in Cancer Cells through CPEB3-Mediated Translational Repression.
Waku T, Katayama H, Hiraoka M, Hatanaka A, Nakamura N, Tanaka Y, Tamura N, Watanabe A, Kobayashi A., Free PMC Article | 08/22/2020 |
| analysis provides a comprehensive description of differential and overlapping gene regulation by the transcriptional regulators NFE2L1(NRF1), NFE2L2 (NRF2), and NFE2L3 (NRF3). | Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells.
Liu P, Kerins MJ, Tian W, Neupane D, Zhang DD, Ooi A., Free PMC Article | 06/20/2020 |
| High nuclear immunohistochemical NRF1(NFE2L1) expression in pigment cells associated with a worse survival (p = 0.048) in patients with N0 disease at the time of diagnosis, and high nuclear NRF2 (NFE2L2) expression in pigment cells associated with a worse survival. | NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs.
Hämäläinen M, Teppo HR, Skarp S, Haapasaari KM, Porvari K, Vuopala K, Kietzmann T, Karihtala P., Free PMC Article | 04/4/2020 |