| Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. | Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen S, Lei M, Liu K, Min J., Free PMC Article | 04/4/2024 |
| The role of basic leucine zipper transcription factor E4BP4 in cancer: a review and update. | The role of basic leucine zipper transcription factor E4BP4 in cancer: a review and update.
Wang L, Li P, Zhang X, Gu Z, Pan X, Wu Y, Li H. | 01/16/2024 |
| A Potential Role of NFIL3 in Atherosclerosis. | A Potential Role of NFIL3 in Atherosclerosis.
Zeng GG, Zhou J, Jiang WL, Yu J, Nie GY, Li J, Zhang SQ, Tang CK. | 01/4/2024 |
| NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease. | NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease.
Chen L, Shangguan Z, Dong Z, Deng Q, Ding Y, Yang S. | 11/28/2023 |
| NFIL3 and its immunoregulatory role in rheumatoid arthritis patients. | NFIL3 and its immunoregulatory role in rheumatoid arthritis patients.
Du J, Zheng L, Chen S, Wang N, Pu X, Yu D, Yan H, Chen J, Wang D, Shen B, Li J, Pan S., Free PMC Article | 12/3/2022 |
| Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3. | Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3.
Kubo M., Free PMC Article | 05/1/2021 |
| E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. | E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, Liu A, Ouyang J, Min X, Rao S, Zhou W, Wu H, Yoshimura A, Lu Q., Free PMC Article | 02/6/2021 |
| NFIL3 is highly expressed in osteosarcoma tissues and thus promotes the proliferation, migration, and invasion of osteosarcoma cells. NFIL3 is potential to become a new target for development of novel treatment strategies of osteosarcoma. | NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression.
Xu J, Xu G, Zhang T, Chen T, Zhao W, Wang G., Free PMC Article | 05/16/2020 |
| our observations suggest that the NFIL3/PrPc axis, through regulating lamellipodium formation and cell mobility via JNK signaling, plays a critical role in lung cancer invasiveness and metastasis. | Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling.
Lin SC, Lin CH, Shih NC, Liu HL, Wang WC, Lin KY, Liu ZY, Tseng YJ, Chang HK, Lin YC, Yeh YC, Minato H, Fujii T, Wu YC, Chen MY, Chou TY. | 04/18/2020 |
| Depletion of E4BP4 inhibits cancer growth, reduces hepcidin secretion, and reduces G9a nuclear transportation. Iron homeostasis and tumor growth in thyroid cancer may be regulated by an E4BP4-dependent epigenetic mechanism. | E4BP4 promotes thyroid cancer proliferation by modulating iron homeostasis through repression of hepcidin.
Zhou Q, Chen J, Feng J, Wang J., Free PMC Article | 12/14/2019 |
| We propose that E4BP4, being the critical component for the regulation of the above signaling processes, may serve as a novel therapeutic target for Heart failure , and scientific investigations are merited in this direction. | A minireview of E4BP4/NFIL3 in heart failure.
Velmurugan BK, Chang RL, Marthandam Asokan S, Chang CF, Day CH, Lin YM, Lin YC, Kuo WW, Huang CY. | 09/28/2019 |
| E4BP4 contribute to enhance the GCs sensitivity. | E4BP4 facilitates glucocorticoid sensitivity of human bronchial epithelial cells via down-regulation of glucocorticoid receptor-beta.
Wang Z, Wang C, Wang Y, Mo B, Wei J, Ma L, Rao L, Wang J, Yao D, Huang J, Xu Q, Yang J, Chen G, Mo B. | 08/3/2019 |
| STAT3/NFIL3 axis-inhibited apoptosis is a novel mechanism of chemotherapy resistance in choriocarcinoma. With the suppression of STAT3/NFIL3 axis and apoptosis induction, RA is a potential agent or lead candidate for improving chemotherapy. | The STAT3/NFIL3 signaling axis-mediated chemotherapy resistance is reversed by Raddeanin A via inducing apoptosis in choriocarcinoma cells.
Peng Z, Zhang C, Zhou W, Wu C, Zhang Y., Free PMC Article | 05/18/2019 |
| Our results indicate that the action of E4bp4 in NK cells is highly regulated and can potentially be strongly influenced by extrinsic stimuli | Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Kostrzewski T, Borg AJ, Meng Y, Filipovic I, Male V, Wack A, DiMaggio PA, Brady HJM., Free PMC Article | 03/2/2019 |
| data provide evidence that E4BP4 attenuates RASSF8-mediated anti-proliferation and apoptosis, shedding mechanistic insights into RASSF8 down-regulation in breast cancers. | E4BP4/NFIL3 modulates the epigenetically repressed RAS effector RASSF8 function through histone methyltransferases.
Karthik IP, Desai P, Sukumar S, Dimitrijevic A, Rajalingam K, Mahalingam S., Free PMC Article | 12/22/2018 |
| Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies | The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases.
Yin J, Zhang J, Lu Q. | 09/2/2017 |
| glucocorticoid-mediated transactivating pathway may support eosinophil viability in IL-5-stimulated cells through synergistic upregulation of NFIL3 | Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3.
Pazdrak K, Moon Y, Straub C, Stafford S, Kurosky A., Free PMC Article | 12/17/2016 |
| E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1 | Glucocorticoid-mediated co-regulation of RCAN1-1, E4BP4 and BIM in human leukemia cells susceptible to apoptosis.
Saenz GJ, Hovanessian R, Gisis AD, Medh RD., Free PMC Article | 11/7/2015 |
| Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. | E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells.
Rawat A, Gopisetty G, Thangarajan R. | 09/26/2015 |
| NFIL3 plays a neuroprotective role in neurons and constitutes a potential therapeutic target for neurodegeneration. | Neuroprotective role of the basic leucine zipper transcription factor NFIL3 in models of amyotrophic lateral sclerosis.
Tamai S, Imaizumi K, Kurabayashi N, Nguyen MD, Abe T, Inoue M, Fukada Y, Sanada K., Free PMC Article | 03/22/2014 |
| Data indicate that E4BP4 can inhibit CD40L expression through epigenetic modifications in the promoter region of CD40L. | E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients.
Zhao M, Liu Q, Liang G, Wang L, Luo S, Tang Q, Zhao H, Su Y, Yung S, Chan TM, Lu Q. | 11/2/2013 |
| NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the menu of FOXO target genes | Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.
Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R., Free PMC Article | 06/29/2013 |
| The clock-regulated and immune system modulator transcription factor E4BP4/ NFIL3 likely regulates the expression of both appb in zebrafish and APP in humans. | Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans.
Shakes LA, Du H, Wolf HM, Hatcher C, Norford DC, Precht P, Sen R, Chatterjee PK., Free PMC Article | 06/15/2013 |
| G9a mediates E4BP4-dependent suppression of hepatic Fgf21 by enhancing histone methylation (H3K9me2) of the Fgf21 promoter | Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein.
Tong X, Zhang D, Buelow K, Guha A, Arthurs B, Brady HJ, Yin L., Free PMC Article | 04/27/2013 |
| Conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development. | E4BP4 is a cardiac survival factor and essential for embryonic heart development.
Weng YJ, Hsieh DJ, Kuo WW, Lai TY, Hsu HH, Tsai CH, Tsai FJ, Lin DY, Lin JA, Huang CY, Tung KC. | 09/27/2010 |