| Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner. | Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner.
Gu W, Fillebeen C, Pantopoulos K., Free PMC Article | 10/15/2022 |
| ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. | ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H. | 04/30/2022 |
| The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis. | The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis.
Hognon C, Bignon E, Harle G, Touche N, Grandemange S, Monari A., Free PMC Article | 01/15/2022 |
| Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis. | Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis.
Oskarsson GR, Oddsson A, Magnusson MK, Kristjansson RP, Halldorsson GH, Ferkingstad E, Zink F, Helgadottir A, Ivarsdottir EV, Arnadottir GA, Jensson BO, Katrinardottir H, Sveinbjornsson G, Kristinsdottir AM, Lee AL, Saemundsdottir J, Stefansdottir L, Sigurdsson JK, Davidsson OB, Benonisdottir S, Jonasdottir A, Jonasdottir A, Jonsson S, Gudmundsson RL, Asselbergs FW, Tragante V, Gunnarsson B, Masson G, Thorleifsson G, Rafnar T, Holm H, Olafsson I, Onundarson PT, Gudbjartsson DF, Norddahl GL, Thorsteinsdottir U, Sulem P, Stefansson K., Free PMC Article | 06/19/2021 |
| Cellular iron sensing and regulation: Nuclear IRP1 extends a classic paradigm. | Cellular iron sensing and regulation: Nuclear IRP1 extends a classic paradigm.
Hernández-Gallardo AK, Missirlis F. | 10/24/2020 |
| HIF-1alpha overexpression enhanced the mRNA levels of TfR1 and DMT1(+IRE), which reversed the inhibition of IRP1 on both. | The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia.
Yang L, Wang D, Wang XT, Lu YP, Zhu L. | 05/18/2019 |
| These results support the concept that IRP1 is an oxidative stress biosensor that mediates iron accumulation and cell death when deregulated by mitochondrial dysfunction. | Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1.
Urrutia PJ, Aguirre P, Tapia V, Carrasco CM, Mena NP, Núñez MT. | 12/1/2018 |
| Results indicate that there is a dysregulation of DMT1 + IRE in IA testes, which might due to the up-regulation of IRP1 and HIF-1A. | Pathological changes in Sertoli cells and dysregulation of divalent metal transporter 1 with iron responsive element in the testes of idiopathic azoospermia patients.
Jing T, Wang P, Liu Y, Zhao J, Niu X, Wang X. | 09/22/2018 |
| Evaluation of the iron regulatory protein-1 interactome has been presented. | Evaluation of the iron regulatory protein-1 interactome.
Connell GJ, Danial JS, Haastruthers CX. | 08/11/2018 |
| regulatory circuit involving FBXL5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth | A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.
Johnson NB, Deck KM, Nizzi CP, Eisenstein RS., Free PMC Article | 10/14/2017 |
| Data suggest that Fe-S cluster of IRP1 plays role in sensing/regulating cellular iron homeostasis; IRP1 alternates between function as cytosolic aconitase [which contains Fe(4)-S(4) cluster in active-site cleft] and function as apoenzyme [which lacks Fe-S cluster] that binds to iron response element stem-loop structures present in several iron regulatory protein transcripts. [REVIEW] | Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways.
Rouault TA, Maio N., Free PMC Article | 08/26/2017 |
| The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer. | Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.
Yuan C, Clish CB, Wu C, Mayers JR, Kraft P, Townsend MK, Zhang M, Tworoger SS, Bao Y, Qian ZR, Rubinson DA, Ng K, Giovannucci EL, Ogino S, Stampfer MJ, Gaziano JM, Ma J, Sesso HD, Anderson GL, Cochrane BB, Manson JE, Torrence ME, Kimmelman AC, Amundadottir LT, Vander Heiden MG, Fuchs CS, Wolpin BM., Free PMC Article | 07/16/2016 |
| Our results confirm the observation that mitoNEET is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET plays important role in this process. | His-87 ligand in mitoNEET is crucial for the transfer of iron sulfur clusters from mitochondria to cytosolic aconitase.
Tan G, Liu D, Pan F, Zhao J, Li T, Ma Y, Shen B, Lyu J. | 06/11/2016 |
| Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia. | Iron Regulatory Protein 1 Suppresses Hypoxia-Induced Iron Uptake Proteins Expression and Decreases Iron Levels in HepG2 Cells.
Cheng CM, Wang D, Cao X, Luo QQ, Lu YP, Zhu L. | 05/14/2016 |
| These in vitro studies suggest that human GLRX3 is important for cytosolic Fe-S protein maturation. | Human glutaredoxin 3 can bind and effectively transfer [4Fe-4S] cluster to apo-iron regulatory protein 1.
Xia H, Li B, Zhang Z, Wang Q, Qiao T, Li K. | 11/28/2015 |
| SIRT3 overexpression decreases TfR1 expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells. | SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC., Free PMC Article | 08/1/2015 |
| ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue. | Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis.
Moreno M, Ortega F, Xifra G, Ricart W, Fernández-Real JM, Moreno-Navarrete JM. | 06/27/2015 |
| ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy | Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy.
Kallianpur AR, Jia P, Ellis RJ, Zhao Z, Bloss C, Wen W, Marra CM, Hulgan T, Simpson DM, Morgello S, McArthur JC, Clifford DB, Collier AC, Gelman BB, McCutchan JA, Franklin D, Samuels DC, Rosario D, Holzinger E, Murdock DG, Letendre S, Grant I, CHARTER Study Group., Free PMC Article | 05/16/2015 |
| MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1. | The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1.
Ferecatu I, Gonçalves S, Golinelli-Cohen MP, Clémancey M, Martelli A, Riquier S, Guittet E, Latour JM, Puccio H, Drapier JC, Lescop E, Bouton C., Free PMC Article | 02/7/2015 |
| Polymer-dependent translocation of IRP-1 in Cd(2+)-exposed cells may underlie effects of Cd(2+) on iron homeostasis. | Cadmium-induced aggregation of iron regulatory protein-1.
Liu Y, Xiao W, Templeton DM. | 11/8/2014 |
| Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP mRNA. | Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.
Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT., Free PMC Article | 04/26/2014 |
| Aco1 encodes a moonlighting protein that has aconitase activity as well as mRNA binding ability. | The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.
Philpott CC, Klausner RD, Rouault TA., Free PMC Article | 01/27/2014 |
| Data indicate that silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, including iron-regulatory protein 1, a major component of posttranscriptional iron regulation. | Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation.
Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R, Berndt C, Lillig CH., Free PMC Article | 01/18/2014 |
| Studies indicate that several genes have been linked to iron homeostasis, including transferrin (TF), iron regulatory protein 1 (ACO1) and transferrin receptor 2 (TFR2). | Neuroimaging, nutrition, and iron-related genes.
Jahanshad N, Rajagopalan P, Thompson PM., Free PMC Article | 01/11/2014 |
| Lead specifically induces dysregulation of IRP1 protein by activating the ERK1/2 signaling pathway indicating a novel role for IRP1 and the ERK/MAPK pathway in vascular endothelial functions. | Lead induces dysregulation of iron regulatory protein 1 via the extracellular signal-regulated kinase pathway in human vascular endothelial cells.
Wang Q, Lin Y, Zhang W, Liu M, Chen Y, Chen J, Luo W. | 02/2/2013 |