| Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity. | Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
Berrocal M, Saez L, Mata AM., Free PMC Article | 07/17/2021 |
| Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases. | Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases.
Boczek T, Sobolczyk M, Mackiewicz J, Lisek M, Ferenc B, Guo F, Zylinska L., Free PMC Article | 05/8/2021 |
| Atomistic Structure and Dynamics of the Ca(2+)-ATPase Bound to Phosphorylated Phospholamban. | Atomistic Structure and Dynamics of the Ca(2+)-ATPase Bound to Phosphorylated Phospholamban.
Aguayo-Ortiz R, Espinoza-Fonseca LM., Free PMC Article | 03/6/2021 |
| Study demonstrated that (a) the distribution and the expression levels of total SERCA1 and SERCA2, the activity of SR Ca2+ ATPase, and the oligomerization of SERCA1 are similar in patients with myotonic dystrophy 1, myotonic dystrophy 2, hypothyroid myopathy and control subjects; and (b) SERCA1b is expressed in patients with myotonic dystrophy, mainly in myotonic dystrophy 2 muscles. | Characterization of sarcoplasmic reticulum Ca(2+) ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy.
Guglielmi V, Oosterhof A, Voermans NC, Cardani R, Molenaar JP, van Kuppevelt TH, Meola G, van Engelen BG, Tomelleri G, Vattemi G. | 01/27/2018 |
| These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity. | Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1).
Desmond PF, Labuza A, Muriel J, Markwardt ML, Mancini AE, Rizzo MA, Bloch RJ., Free PMC Article | 07/8/2017 |
| CAPN3 deficiency leads to degradation of SERCA proteins and Ca2+ dysregulation in the skeletal muscle. | Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.
Toral-Ojeda I, Aldanondo G, Lasa-Elgarresta J, Lasa-Fernández H, Fernández-Torrón R, López de Munain A, Vallejo-Illarramendi A., Free PMC Article | 10/22/2016 |
| The sphingolipid sphingosine increases the [Ca(2+)]i by inhibiting the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), in a similar manner to thapsigargin (Tg), a specific inhibitor of this Ca(2+) pump. | Sphingosine inhibits the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) activity.
Benaim G, Pimentel AA, Felibertt P, Mayora A, Colman L, Sojo F, Rojas H, De Sanctis JB. | 09/3/2016 |
| Thus the human SERCA1b has a different expression pattern from that of rodents and it is associated with DM2. | The neonatal sarcoplasmic reticulum Ca2+-ATPase gives a clue to development and pathology in human muscles.
Kósa M, Brinyiczki K, van Damme P, Goemans N, Hancsák K, Mendler L, Zádor E. | 02/6/2016 |
| Formalin evokes calcium transients from the endoplasmatic reticulum via SERCA1-dependent, TRPA1-independent mechanism that may underlie formaldehyde-induced pan-neuronal excitation and subsequent inflammation. | Formalin evokes calcium transients from the endoplasmatic reticulum.
Fischer MJ, Soller KJ, Sauer SK, Kalucka J, Veglia G, Reeh PW., Free PMC Article | 01/16/2016 |
| We conclude that PLB C-terminal residues are critical for localization, oligomerization, and regulatory function. In particular, the PLB C terminus is an important determinant of the quaternary structure of the SERCA regulatory complex. | Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex.
Abrol N, Smolin N, Armanious G, Ceholski DK, Trieber CA, Young HS, Robia SL., Free PMC Article | 02/21/2015 |
| Aberrant splicing of SERCA1 may alter intracellular Ca(2+) signalling in myotonic dystrophy 1 and 2 myotubes. The differing dysregulation of intracellular Ca(2+) handling in DM1 and DM2 may explain their distinct sarcolemmal hyperexcitabilities. | Alternative splicing alterations of Ca2+ handling genes are associated with Ca2+ signal dysregulation in myotonic dystrophy type 1 (DM1) and type 2 (DM2) myotubes.
Santoro M, Piacentini R, Masciullo M, Bianchi ML, Modoni A, Podda MV, Ricci E, Silvestri G, Grassi C. | 01/31/2015 |
| We performed a detailed study of SERCA1 protein expression in muscle of patients with BD and BS, and evaluated the alternative splicing of SERCA1 in primary cultures of normal human muscle | SERCA1 protein expression in muscle of patients with Brody disease and Brody syndrome and in cultured human muscle fibers.
Guglielmi V, Vattemi G, Gualandi F, Voermans NC, Marini M, Scotton C, Pegoraro E, Oosterhof A, Kósa M, Zádor E, Valente EM, De Grandis D, Neri M, Codemo V, Novelli A, van Kuppevelt TH, Dallapiccola B, van Engelen BG, Ferlini A, Tomelleri G. | 03/22/2014 |
| These results indicate that PKC signaling is involved in the splicing of SERCA1 and provide new evidence for a link between alternative splicing and PKC signaling. | Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.
Zhao Y, Koebis M, Suo S, Ohno S, Ishiura S. | 09/22/2012 |
| both topology and function of PLN are shaped by the interactions with lipids, which fine-tune the regulation of SERCA | Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method.
Verardi R, Shi L, Traaseth NJ, Walsh N, Veglia G., Free PMC Article | 08/27/2011 |
| Differential SERCA1a S-nitrosylation and SERCA1a/2a co-expression in subsets of slow myofibers should be considered as signs of an altered cytosolic Ca(2+) homeostasis following chronic muscle disuse | Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest.
Salanova M, Schiffl G, Blottner D. | 01/21/2010 |
| the increase in mechanical efficiency of cycling occurring during first weeks of endurance training may be due to down-regulation of SERCA pumps | Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.
Majerczak J, Karasinski J, Zoladz JA. | 01/21/2010 |
| The truncated variant of the sarcoendoplasmic reticulum Ca(2+)-ATPase 1 (S1T) amplifies endoplasmic reticulum stress through the PERK-eIF2alpha-ATF4-CHOP pathway. | Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.
Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P., Free PMC Article | 01/21/2010 |
| Ca (2+) binding to Site I of SERCA1a in fact slightly reduces Trp fluorescence, and consequently that the rise in this fluorescence generally observed when two Ca (2+) ions bind to WT SERCA1a mainly reflects Ca (2+) binding at Site II of SERCA1a. | Use of glycerol-containing media to study the intrinsic fluorescence properties of detergent-solubilized native or expressed SERCA1a.
Montigny C, Arnou B, Marchal E, Champeil P. | 01/21/2010 |
| Overexpression of the CUG repeat expansion of DMPK mRNA resulted in exclusion of exon 22 of SERCA1. | Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1.
Hino S, Kondo S, Sekiya H, Saito A, Kanemoto S, Murakami T, Chihara K, Aoki Y, Nakamori M, Takahashi MP, Imaizumi K. | 01/21/2010 |
| Despite similar total calcium contents, lower SERCA and PMCA activities were found in sacs associated with hydrocele compared to those associated with undescended testis suggest a difference among the levels of cytosolic calcium. | Sarco(endo)plasmic reticulum and plasmalemmal Ca(2+)-ATPase activities in cremaster muscles and sacs differ according to the associated inguinal pathology.
Ulusu NN, Tandoğan B, Tanyel FC. | 01/21/2010 |
| a functional abnormality in SERCA1 may have a role in inferior oblique overaction, an ocular motor disorder | Calcium uptake and release through sarcoplasmic reticulum in the inferior oblique muscles of patients with inferior oblique overaction.
Kim HS, Chang YH, Kim DH, Park SR, Han SH, Lee JB., Free PMC Article | 01/21/2010 |
| We suggest that aberrant splicing of SERCA1 mRNAs might contribute to impaired Ca2+ homeostasis in DM1 muscle | Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.
Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S. | 01/21/2010 |
| SERCA1 gene transfer increased fractional myocardial cell shortening (compared to LacZ) and accelerated relengthening kinetics. | Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.
Weisser-Thomas J, Dieterich E, Janssen PM, Schmidt-Schweda S, Maier LS, Sumbilla C, Pieske B. | 01/21/2010 |
| Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase. | Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase.
Toyoshima C, Asahi M, Sugita Y, Khanna R, Tsuda T, MacLennan DH., Free PMC Article | 01/21/2010 |
| kinetic analysis of SERCA1 and SERCA2 isoforms and the effects of mutation | Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.
Dode L, Andersen JP, Leslie N, Dhitavat J, Vilsen B, Hovnanian A. | 01/21/2010 |