| Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours. | Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
Adle-Biassette H, Ricci R, Martin A, Martini M, Ravegnini G, Kaci R, Gélébart P, Poirot B, Sándor Z, Lehman-Che J, Tóth E, Papp B. | 03/15/2024 |
| Data show that the nucleotide sequence from -280 to -135 position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA expression is decreased during gastric and colorectal carcinoma development and tumors with high SERCA3 expression are associated with increased overall survival. These results suggest an essential role for SERCA3 in the regulation of cellular identity and growth, through cellular Ca2+ management. | Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
Meneses-Morales I, Izquierdo-Torres E, Flores-Peredo L, Rodríguez G, Hernández-Oliveras A, Zarain-Herzberg Á. | 11/9/2019 |
| This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects. | Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.
Zhang Y, Li F, Liu L, Jiang H, Hu H, Du X, Ge X, Cao J, Wang Y., Free PMC Article | 08/17/2019 |
| Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation. | Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Flores-Peredo L, Rodríguez G, Zarain-Herzberg A. | 09/2/2017 |
| Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b. | Inhibition and conformational change of SERCA3b induced by Bcl-2.
Hewarathna A, Dremina E, Schöneich C., Free PMC Article | 07/15/2017 |
| ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation. | Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.
Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR. | 06/10/2017 |
| we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas | Regulation of SERCA pumps expression in diabetes.
Zarain-Herzberg A, García-Rivas G, Estrada-Avilés R. | 08/1/2015 |
| Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium. | Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
Ait-Ghezali L, Arbabian A, Jeibmann A, Hasselblatt M, Hallaert GG, Van den Broecke C, Gray F, Brouland JP, Varin-Blank N, Papp B. | 05/30/2015 |
| aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas. | Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
Gou WF, Niu ZF, Zhao S, Takano Y, Zheng HC. | 09/6/2014 |
| The Ca2+-ATPase activity in cloned Plasmodiuim falciparum strain D6 protein is higher than in cloned strain W2 protein. The Ca2+-ATPase activity in isolates from malaria patients varied widely. | Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.
Bolaji OM, Happi TC, Bababunmi EA. | 05/3/2014 |
| Loss of SERCA3 expression is associated with lung cancer. | Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation.
Arbabian A, Brouland JP, Apáti Á, Pászty K, Hegedűs L, Enyedi Á, Chomienne C, Papp B. | 12/7/2013 |
| High SERCA3 expression is associated with pathogenesis, invasion, metastasis of gastric carcinomas. | Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.
Xu XY, Gou WF, Yang X, Wang GL, Takahashi H, Yu M, Mao XY, Takano Y, Zheng HC. | 02/2/2013 |
| SERCA2 and SERCA3 isoforms have roles in the failing and failing human heart | Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart.
Dally S, Corvazier E, Bredoux R, Bobe R, Enouf J. | 11/27/2010 |
| Data show that low Ca2+-affinity SERCA3, and the high Ca2+-affinity SERCA2 enzymes are simultaneously expressed in B cells, and decreased SERCA3 expression during EBV-infection. | Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.
Dellis O, Arbabian A, Brouland JP, Kovàcs T, Rowe M, Chomienne C, Joab I, Papp B., Free PMC Article | 02/22/2010 |
| affinity for Ca(2+) is inherently lower for SERCA3 expressed in situ than for other SERCA isoforms | Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3.
Chandrasekera PC, Kargacin ME, Deans JP, Lytton J. | 01/21/2010 |
| two distinct SERCA3 fragmentation profiles sign the co-expression of SERCA3 proteins in two conformational states in platelet membranes. | Expression of sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) 3 proteins in two major conformational states in native human cell membranes.
Corvazier E, Bredoux R, Kovács T, Enouf J. | 01/21/2010 |
| These findings revisit the human heart's Ca(2+)ATPase system and indicate that SERCA3f may account for the mechanism of endoplasmic reticulum stress in vivo in heart failure. | Compartmentalized expression of three novel sarco/endoplasmic reticulum Ca2+ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart.
Dally S, Monceau V, Corvazier E, Bredoux R, Raies A, Bobe R, del Monte F, Enouf J. | 01/21/2010 |
| ATP2A3 gene is involved in cancer susceptibility. | ATP2A3 gene is involved in cancer susceptibility.
Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M, Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | ATP2A3 gene is involved in cancer susceptibility.
Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M, Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M. | 01/11/2009 |
| Ca2+ ATPase sarcoplasmic/endoplasmic reticulum calcium ATPase 3 are involved in an increased susceptibility to develop head and neck squamous cell carcinoma in humans. | Alterations in genes encoding sarcoplasmic-endoplasmic reticulum Ca(2+) pumps in association with head and neck squamous cell carcinoma.
Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M. | 01/21/2010 |
| These results suggest that SERCA2b and 3 modulate thrombin-stimulated store-operated Ca(2+)entry probably by direct interaction with the hTRPC1 channel in human platelets. | SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.
Redondo PC, Salido GM, Pariente JA, Sage SO, Rosado JA. | 01/21/2010 |
| novel sarco/endoplasmic isoforms; data suggest that the SERCA3 gene products have a more widespread role in cellular Ca2+ signaling than previously appreciated | Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family.
Martin V, Bredoux R, Corvazier E, Van Gorp R, Kovacs T, Gelebart P, Enouf J. | 01/21/2010 |
| Results describe the catalytic cycle of three human SERCA3 isoenzymes: SERCA3a, b, and c. | Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses.
Dode L, Vilsen B, Van Baelen K, Wuytack F, Clausen JD, Andersen JP. | 01/21/2010 |
| link SERCA3 expression to the state of differentiation of colonic epithelial cells | The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Brouland JP, Gélébart P, Kovàcs T, Enouf J, Grossmann J, Papp B., Free PMC Article | 01/21/2010 |
| By increasing the rate of Ca2+ sequestration, up-regulation of SERCA 3 counteracts the cytosolic increase in Ca2+ concentration. | Transcription of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells.
Hadri L, Pavoine C, Lipskaia L, Yacoubi S, Lompré AM., Free PMC Article | 01/21/2010 |