| DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth. | DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
Barra J, Crosbourne I, Roberge CL, Bossardi-Ramos R, Warren JSA, Matteson K, Wang L, Jourd'heuil F, Borisov SM, Bresnahan E, Bravo-Cordero JJ, Dmitriev RI, Jourd'heuil D, Adam AP, Lamar JM, Corr DT, Barroso MM., Free PMC Article | 02/28/2024 |
| DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis. | DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
Tan Q, Zhang X, Li S, Liu W, Yan J, Wang S, Cui F, Li D, Li J. | 10/2/2023 |
| SLC11A2: a promising biomarker and therapeutic target in ovarian cancer. | SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
Tian L, Li X, Lai H, Sun T, Li X, Wu L, Wu C, Yao S, Ren Y, He S, Yang G., Free PMC Article | 02/11/2023 |
| Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia. | Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
Pandey S, Kunder S, Bajaj N, Dwivedi S, Singh J, Shinde S, Pandey D, Pandey SK. | 10/22/2022 |
| Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs. | Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
Sugino Y, Uchiyama R, Shibasaki C, Kugawa F. | 09/10/2022 |
| The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer. | The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
Michalczyk K, Kapczuk P, Witczak G, Bosiacki M, Kurzawski M, Chlubek D, Cymbaluk-Płoska A., Free PMC Article | 08/6/2022 |
| DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY? | DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
Piatto VB, Ferdinando DLT, Funes HLX., Free PMC Article | 06/25/2022 |
| Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals. | Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
Mani MS, Dsouza VL, Dsouza HS. | 02/12/2022 |
| Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population. | Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
Li C, Ou R, Chen Y, Gu X, Wei Q, Cao B, Zhang L, Hou Y, Liu K, Chen X, Song W, Zhao B, Wu Y, Shang H. | 12/25/2021 |
| Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14. | Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14.
Widhalm R, Ellinger I, Granitzer S, Forsthuber M, Bajtela R, Gelles K, Hartig PY, Hengstschläger M, Zeisler H, Salzer H, Gundacker C. | 10/9/2021 |
| alpha-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models. | α-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models.
Bi M, Du X, Jiao Q, Liu Z, Jiang H. | 07/31/2021 |
| the interaction of aromatic bis-isothiourea-substituted compounds with human DMT1 and its prokaryotic homologue EcoDMT, is reported. | Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.
Manatschal C, Pujol-Giménez J, Poirier M, Reymond JL, Hediger MA, Dutzler R., Free PMC Article | 05/16/2020 |
| Enhanced expression of apical membrane- and basolateral membrane-localized DMT1 and FPN1 in UC human colon. | Increased DMT1 and FPN1 expression with enhanced iron absorption in ulcerative colitis human colon.
Minor EA, Kupec JT, Nickerson AJ, Narayanan K, Rajendran VM., Free PMC Article | 05/9/2020 |
| The results highlighted a protective association of A-T-T haplotype against the risk of Age-related cataract (ARC). | Protective association of A-T-T haplotype of DMT1 gene against risk of human age-related nuclear cataract.
Sankaranarayanan R, Vidya NG, Vasavada AR. | 03/14/2020 |
| To better understand the mechanisms of zinc-induced iron absorption, we have studied the effect of zinc on iron uptake, iron transporter and iron regulatory protein (IRP 1 and 2) expression and the impact of the PI3K pathway in differentiated Caco-2 cells, an intestinal cell culture model. We found that zinc induces DMT1 protein and mRNA expression. | Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism.
Kondaiah P, Aslam MF, Mashurabad PC, Sharp PA, Pullakhandam R. | 02/29/2020 |
| We summarize DMT1 expression depending on the types of cell or tissue and the function and mechanism of one of the iron chaperones, PCBP2 | DMT1 and iron transport.
Yanatori I, Kishi F. | 02/15/2020 |
| The loss of CTR1 resulted in a decrease in the level of COMMD1, XIAP, and NF-kappaB. Differently, the DMT1 deficiency induced increase of the COMMD1, HIF1alpha, and XIAP levels. | CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences.
Ilyechova EY, Bonaldi E, Orlov IA, Skomorokhova EA, Puchkova LV, Broggini M., Free PMC Article | 11/30/2019 |
| Low DMT1 expression associates with increased oxidative phosphorylation as well as glycolysis and identifies early recurrence in hepatocellular carcinoma patients after surgical treatment. | Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma.
Hoki T, Katsuta E, Yan L, Takabe K, Ito F., Free PMC Article | 11/16/2019 |
| PKCalpha promotes microvillus membrane DMT1 expression. | Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner.
Zhao L, Bartnikas T, Chu X, Klein J, Yun C, Srinivasan S, He P., Free PMC Article | 11/16/2019 |
| A compound heterozygote with hereditary hypochromic microcytic anemia was found to have 2 new DMT1 mutations: a C > T transition at nucleotide 1429 of exon 15 (R477W) and a G > C substitution at position +1 bp of the splice-donor site within intron 4 (ivs4 + 1 G/C). R477W was inherited from proband's mother, while ivs4 + 1 G/C was of paternal inheritance. | Hereditary hypochromic microcytic anemia associated with loss-of-function DMT1 gene mutations and absence of liver iron overload.
Casale M, Borriello A, Scianguetta S, Roberti D, Caiazza M, Bencivenga D, Tartaglione I, Ladogana S, Maruzzi M, Della Ragione F, Perrotta S. | 04/27/2019 |
| Solute carrier family-11 member-2 (SLC11A2) homozygous CC genotype for IVS4+44C/A showed significant correlation with Type-2 diabetes (T2DM) risk, suggesting that presence of C allele of IVS4+44C/A plays pathological roles. | The genetic variants of solute carrier family 11 member 2 gene and risk of developing type-2 diabetes.
Ozbayer C, Kurt H, Nur Kebapci M, Veysi Gunes H, Colak E, Degirmenci I. | 02/9/2019 |
| E193 in hDMT1, is proposed to translocate protons in an inward-rectified manner by alternating contact with the solvent on each side of the membrane bilayer. Furthermore, molecular dynamics simulations provide insight into how H(+)-translocation through E193 is allosterically linked to intracellular gating, establishing a novel transport mechanism distinct from that of other H(+)-coupled transporters. | A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters.
Pujol-Giménez J, Hediger MA, Gyimesi G., Free PMC Article | 02/2/2019 |
| DMT1 was increased in myelodysplastic syndrome patients. | Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Muto Y, Nishiyama M, Nita A, Moroishi T, Nakayama KI., Free PMC Article | 12/29/2018 |
| SLC11A2 expression is increased in the intestine of patients with type 2 diabetes in association with iron stores and serum hepcidin levels. | Increased Small Intestine Expression of Non-Heme Iron Transporters in Morbidly Obese Patients With Newly Diagnosed Type 2 Diabetes.
Moreno-Navarrete JM, Rodríguez A, Becerril S, Valentí V, Salvador J, Frühbeck G, Fernández-Real JM. | 12/29/2018 |
| Results indicate that there is a dysregulation of DMT1 + IRE in IA testes, which might due to the up-regulation of IRP1 and HIF-1A. | Pathological changes in Sertoli cells and dysregulation of divalent metal transporter 1 with iron responsive element in the testes of idiopathic azoospermia patients.
Jing T, Wang P, Liu Y, Zhao J, Niu X, Wang X. | 09/22/2018 |