| CircNRD1 elevates THAP domain containing 11 through sequestering microRNA-421 to inhibit gastric cancer growth and tumorigenesis. | CircNRD1 elevates THAP domain containing 11 through sequestering microRNA-421 to inhibit gastric cancer growth and tumorigenesis.
Liu A, Liang J, Wen J. | 04/22/2024 |
| Altered Levels of Negative Costimulatory Molecule V-Set Domain-Containing T-Cell Activation Inhibitor-1 (VTCN1) and Metalloprotease Nardilysin (NRD1) are Associated with Generalized Active Vitiligo. | Altered Levels of Negative Costimulatory Molecule V-Set Domain-Containing T-Cell Activation Inhibitor-1 (VTCN1) and Metalloprotease Nardilysin (NRD1) are Associated with Generalized Active Vitiligo.
Vaishnav J, Jadeja SD, Singh M, Khan F, Yadav M, Begum R. | 10/8/2022 |
| Increased serum nardilysin at admission is associated with a higher risk of all-cause mortality for ST-elevation myocardial infarction patients. | Increased serum nardilysin is associated with worse long-term outcome of ST-elevation myocardial infarction.
Miao CQ, Lu Q, Liu P, Bai L, Qu H, Ma AQ. | 11/16/2019 |
| NRDC expression was reduced in infarcted regions in autopsy samples from acute myocardial ischemia patients. | Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome.
Chen PM, Ohno M, Hiwasa T, Nishi K, Saijo S, Sakamoto J, Morita Y, Matsuda S, Watanabe S, Kuwabara Y, Ono K, Imai M, Inoue K, Murai T, Inada T, Tanaka M, Kita T, Kimura T, Nishi E. | 04/21/2018 |
| Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls. | Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population.
Ma SL, Tang NL, Lam LC. | 12/17/2016 |
| MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples. | NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.
Uraoka N, Oue N, Sakamoto N, Sentani K, Oo HZ, Naito Y, Noguchi T, Yasui W., Free PMC Article | 07/5/2014 |
| This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism. | Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics.
Bernstein HG, Stricker R, Zschiebsch K, Müller S, Dobrowolny H, Steiner J, Bogerts B, Reiser G. | 05/31/2014 |
| possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review] | Nardilysin in human brain diseases: both friend and foe.
Bernstein HG, Stricker R, Dobrowolny H, Steiner J, Bogerts B, Trübner K, Reiser G. | 01/4/2014 |
| SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42(IP4) show enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation. | Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells.
Borrmann C, Stricker R, Reiser G. | 02/2/2013 |
| NRD1 interacts with p53 mutant R273H | Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
Coffill CR, Muller PA, Oh HK, Neo SP, Hogue KA, Cheok CF, Vousden KH, Lane DP, Blackstock WP, Gunaratne J., Free PMC Article | 11/17/2012 |
| These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha. | Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.
Kanda K, Komekado H, Sawabu T, Ishizu S, Nakanishi Y, Nakatsuji M, Akitake-Kawano R, Ohno M, Hiraoka Y, Kawada M, Kawada K, Sakai Y, Matsumoto K, Kunichika M, Kimura T, Seno H, Nishi E, Chiba T., Free PMC Article | 08/25/2012 |
| Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. | Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Li J, Chu M, Wang S, Chan D, Qi S, Wu M, Zhou Z, Li J, Nishi E, Qin J, Wong J., Free PMC Article | 05/19/2012 |
| Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively. | A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
Wang KS, Liu X, Zhang Q, Pan Y, Aragam N, Zeng M. | 03/17/2012 |
| Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1). | Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1).
Borrmann C, Stricker R, Reiser G. | 02/25/2012 |
| mediates antigen processing that generates cytotoxic T cell epitopes | Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. | 05/14/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium. | Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium.
Korovkina VP, Stamnes SJ, Brainard AM, England SK., Free PMC Article | 01/21/2010 |
| These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha. | Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E. | 01/21/2010 |
| We found high staining intensity in the hypothalamus, neocortex and brain stem nuclei. The cellular localization is almost exclusively confined to neurons. In pre- and perinatal human brain cortex, most neurons express the enzyme. | Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons.
Bernstein HG, Stricker R, Dobrowolny H, Trübner K, Bogerts B, Reiser G. | 01/21/2010 |
| Nardilysin has an essential role in HB-EGF ectodomain shedding, which is regulated by the modulation of sheddase activity | Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme.
Nishi E, Hiraoka Y, Yoshida K, Okawa K, Kita T. | 01/21/2010 |
| nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) | The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).
Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A., Free PMC Article | 01/21/2010 |
| N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration. | N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.
Nishi E, Prat A, Hospital V, Elenius K, Klagsbrun M., Free PMC Article | 09/12/2002 |
| The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. | Expression of the acidic stretch of nardilysin as a functional binding domain.
Ma Z, Csuhai E, Chow KM, Hersh LB. | 10/23/2001 |