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    NT5E 5'-nucleotidase ecto [ Homo sapiens (human) ]

    Gene ID: 4907, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing hemodialysis.

    CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing hemodialysis.
    Xiang F, Sun L, Cao X, Li Y, Chen X, Zhang Z, Zou J, Teng J, Shen B, Ding X.

    02/27/2024
    Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response.

    Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response.
    Ortiz MA, Diaz-Torné C, De Agustin JJ, Estrada P, Reina D, Hernandez MV, Sang H, Zamora C, Cantó E, Corominas H, Vidal S., Free PMC Article

    02/6/2024
    Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73).

    Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73).
    Sosa-Luis SA, Ríos-Ríos WJ, Almaraz-Arreortua A, Romero-Tlalolini MA, Aguilar-Ruiz SR, Valle-Ríos R, Sánchez-Torres C, Torres-Aguilar H., Free PMC Article

    02/1/2024
    CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway.

    CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway.
    Hernandez KC, Shah AM, Lopez VA, Tagliabracci VS, Chen K, Xu L, Bassel-Duby R, Olson EN, Liu N.,

    01/29/2024
    The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency.

    The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency.
    Sperber HS, Raymond KA, Bouzidi MS, Ma T, Valdebenito S, Eugenin EA, Roan NR, Deeks SG, Winning S, Fandrey J, Schwarzer R, Pillai SK., Free PMC Article

    12/5/2023
    Effects of abnormal expression of CD73 on malignant phenotype of nasopharyngeal carcinoma.

    Effects of abnormal expression of CD73 on malignant phenotype of nasopharyngeal carcinoma.
    Jiang B, Tang M, Shi S, Xie H, Pan S, Zhang L, Sheng J.

    11/16/2023
    CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells.

    CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells.
    Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM, Sanz-Moreno V., Free PMC Article

    10/30/2023
    Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma.

    Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma.
    Sun BY, Yang ZF, Wang ZT, Liu G, Zhou C, Zhou J, Fan J, Gan W, Yi Y, Qiu SJ., Free PMC Article

    10/26/2023
    5'-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells.

    5'-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells.
    Shi E, Wu Z, Karaoglan BS, Schwenk-Zieger S, Kranz G, Abdul Razak N, Reichel CA, Canis M, Baumeister P, Zeidler R, Gires O., Free PMC Article

    09/1/2023
    The CD73 is induced by TGF-beta1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma.

    The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma.
    Giraulo C, Turiello R, Orlando L, Leonardelli S, Landsberg J, Belvedere R, Rolshoven G, Müller CE, Hölzel M, Morello S.

    08/17/2023
    The Clinical Significance of CD73 in Cancer.

    The Clinical Significance of CD73 in Cancer.
    Bach N, Winzer R, Tolosa E, Fiedler W, Brauneck F., Free PMC Article

    08/3/2023
    The CD73 immune checkpoint promotes tumor cell metabolic fitness.

    The CD73 immune checkpoint promotes tumor cell metabolic fitness.
    Allard D, Cousineau I, Ma EH, Allard B, Bareche Y, Fleury H, Stagg J., Free PMC Article

    06/16/2023
    NT5E DNA methylation in papillary thyroid cancer: Novel opportunities for precision oncology.

    NT5E DNA methylation in papillary thyroid cancer: Novel opportunities for precision oncology.
    Bertoni APS, Valandro CF, Brasil RÁ, Zeiser FA, Wink MR, Furlanetto TW, da Costa CA.

    05/22/2023
    CD73 in glioblastoma: Where are we now and what are the future directions?

    CD73 in glioblastoma: Where are we now and what are the future directions?
    Gelsleichter NE, Azambuja JH, Rubenich DS, Braganhol E.

    05/8/2023
    Single-Cell Phenotyping of CD73 Expression Reveals the Diversity of the Tumor Immune Microenvironment and Reflects the Prognosis of Bladder Cancer.

    Single-Cell Phenotyping of CD73 Expression Reveals the Diversity of the Tumor Immune Microenvironment and Reflects the Prognosis of Bladder Cancer.
    Izawa M, Tanaka N, Murakami T, Anno T, Teranishi Y, Takamatsu K, Mikami S, Kakimi K, Imamura T, Matsumoto K, Oya M.

    04/26/2023
    CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.

    CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
    Faraoni EY, Singh K, Chandra V, Le Roux O, Dai Y, Sahin I, O'Brien BJ, Strickland LN, Li L, Vucic E, Warner AN, Pruski M, Clark T, Van Buren G, Thosani NC, Bynon JS, Wray CJ, Bar-Sagi D, Poulsen KL, Vornik LA, Savage MI, Sei S, Mohammed A, Zhao Z, Brown PH, Mills T, Eltzschig HK, McAllister F, Bailey-Lundberg JM., Free PMC Article

    04/6/2023
    AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression.

    AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression.
    Cheng HH, Hung-Ke L, Sheu ML, Lee CY, Tsai YC, Lai DW.

    03/28/2023
    The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy.

    The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy.
    Jiang X, Wu X, Xiao Y, Wang P, Zheng J, Wu X, Jin Z., Free PMC Article

    02/15/2023
    CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence.

    CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence.
    Liu Z, Wu B, Liu X, Wu X, Du J, Xia G, Cai J, Zhu H, Sheng X, Zhang M, Xu J, Xu T, Lv X., Free PMC Article

    02/14/2023
    Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.

    Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
    Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y., Free PMC Article

    01/21/2023
    Evaluation of CD39, CD73, HIF-1alpha, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women.

    Evaluation of CD39, CD73, HIF-1α, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women.
    Yousefzadeh Y, Soltani-Zangbar MS, Kalafi L, Tarbiat A, Shahmohammadi Farid S, Aghebati-Maleki L, Parhizkar F, Danaii S, Taghavi S, Jadidi-Niaragh F, Samadi Kafil H, Mahmoodpoor A, Ahmadian Heris J, Hojjat-Farsangi M, Yousefi M.

    11/5/2022
    Functional expression of CD73 on human natural killer cells.

    Functional expression of CD73 on human natural killer cells.
    Chambers AM, Wang J, Dao TN, Lupo KB, Veenhuis P, Ayers MG, Slivova V, Cohen-Gadol AA, Matosevic S., Free PMC Article

    10/29/2022
    Variability in CD39 and CD73 protein levels in uveal melanoma patients.

    Variability in CD39 and CD73 protein levels in uveal melanoma patients.
    Harou O, Cros-Perrial E, Alix E, Callet-Bauchu E, Bertheau C, Dumontet C, Devouassoux-Shisheboran M, Jordheim LP.

    10/29/2022
    Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts.

    Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts.
    Gao Z, Wang L, Song Z, Ren M, Yang Y, Li J, Shen K, Li Y, Ding Y, Yang Y, Zhou Y, Wei C, Gu J., Free PMC Article

    10/1/2022
    NT5E upregulation in head and neck squamous cell carcinoma: A novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment.

    NT5E upregulation in head and neck squamous cell carcinoma: A novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment.
    Chen XM, Liu YY, Tao BY, Xue XM, Zhang XX, Wang LL, Zhong H, Zhang J, Yang SM, Jiang QQ., Free PMC Article

    10/1/2022
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