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    NTF3 neurotrophin 3 [ Homo sapiens (human) ]

    Gene ID: 4908, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.

    Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma.
    Wang H, Zhong C, Qi L, Fang X, Yuan Y.

    11/2/2023
    Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway.

    Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway.
    Xu X, Song L, Li Y, Guo J, Huang S, Du S, Li W, Cao R, Cui S., Free PMC Article

    11/1/2023
    Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways.

    Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways.
    Yang Z, Zhang H, Yin M, Cheng Z, Jiang P, Feng M, Liao B, Liu Z., Free PMC Article

    10/29/2022
    Biochemical Assessments of Neurotrophin-3 and Zinc Involvement in the Pathophysiology of Pediatric Febrile Seizures : Biochemical Markers in Febrile Seizures.

    Biochemical Assessments of Neurotrophin-3 and Zinc Involvement in the Pathophysiology of Pediatric Febrile Seizures : Biochemical Markers in Febrile Seizures.
    Bakri AH, Hassan MH, Ahmed AE, Halim PR, El-Sawy SA, Mohamed MM, Rashwan NI.

    06/11/2022
    Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder.

    Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder.
    Requena-Ocaña N, Araos P, Flores M, García-Marchena N, Silva-Peña D, Aranda J, Rivera P, Ruiz JJ, Serrano A, Pavón FJ, Suárez J, Rodríguez de Fonseca F., Free PMC Article

    11/6/2021
    Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.

    Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.
    Cui X, Jing J, Wu R, Cao Q, Li F, Li K, Wang S, Yu L, Schwartz G, Shi H, Xue B, Shi H., Free PMC Article

    10/16/2021
    The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.

    The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.
    Rodrigues-Amorim D, Iglesias-Martínez-Almeida M, Rivera-Baltanás T, Fernández-Palleiro P, Freiría-Martínez L, Rodríguez-Jamardo C, Comís-Tuche M, Vallejo-Curto MDC, Álvarez-Ariza M, López-García M, de Las Heras E, García-Caballero A, Olivares JM, Spuch C., Free PMC Article

    09/18/2021
    Neurotrophin 3 ligand-coated with silver nanoparticle was induced in the model to normalize the transcription of myelin gene

    Silver nanoparticles conjugated with Neurotrophin 3 upregulate myelin gene transcription pathway.
    Munir A, Hussain S, Dilshad E.

    10/26/2019
    In patients with schizophrenia, serum levels of neurotrophin-3 are increased only if depressive symptoms are also present.

    In schizophrenia serum level of neurotrophin-3 (NT-3) is increased only if depressive symptoms are present.
    Arabska J, Łucka A, Strzelecki D, Wysokiński A.

    02/23/2019
    NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation.

    NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.
    Lin YJ, Hsin IL, Sun HS, Lin S, Lai YL, Chen HY, Chen TY, Chen YP, Shen YT, Wu HM., Free PMC Article

    12/22/2018
    brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study

    Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study.
    Sheldrick A, Camara S, Ilieva M, Riederer P, Michel TM.

    05/19/2018
    NT-3 has been shown to be both an osteogenic and angiogenic factor, and can also enhance expression of the key osteogenic factor, BMP-2, as well as the major angiogenic factor, VEGF, to promote bone formation, vascularization, and bone healing

    Roles of neurotrophins in skeletal tissue formation and healing.
    Su YW, Zhou XF, Foster BK, Grills BL, Xu J, Xian CJ.

    12/16/2017
    High expression of NT-3 is associated with glioblastoma.

    Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.
    Jawhari S, Bessette B, Hombourger S, Durand K, Lacroix A, Labrousse F, Jauberteau MO, Ratinaud MH, Verdier M.

    09/9/2017
    Meta-analysis found the levels of both NT-3 and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion.

    State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis.
    Tseng PT, Chen YW, Tu KY, Wang HY, Chung W, Wu CK, Hsu SP, Kuo HC, Lin PY.

    09/2/2017
    NT3 upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt-cyclin D1 cascade.

    Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis.
    Yao Q, Song R, Ao L, Cleveland JC Jr, Fullerton DA, Meng X., Free PMC Article

    08/5/2017
    The analysis of covariance (ANCOVA) indicated that the mean serum GDNF and NTF3 levels of ADHD patients were significantly higher than that of controls. However, serum BDNF and NGF levels did not show any significant differences between groups. These results suggest that elevated serum GDNF and NTF3 levels may be related to ADHD in children.

    Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.
    Bilgiç A, Toker A, Işık Ü, Kılınç İ.

    04/1/2017
    All patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined.

    Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity.
    Ogłodek EA, Just MJ, Szromek AR, Araszkiewicz A.

    03/25/2017
    There were no differences in neurotrophin levels between patients with schizophrenia and controls. We found lower BDNF and higher NT-3 serum levels in depressed patients with schizophrenia.

    Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia.
    Wysokiński A.

    12/17/2016
    The results suggest a gene dose-association between the A allele of rs6332 and the onset of AD in varepsilon4 non-carriers and the NTF-3 rs6489630 polymorphism being a relevant risk factor for AD in patients lacking the ApoE-varepsilon4 allele in this Chinese sample.

    Polymorphisms of the neurotrophic factor-3 (NTF-3) in Alzheimer's disease: rs6332 associated with onset time and rs6489630 T allele exhibited a protective role.
    Liu M, Huo YR, Wang J, Liu S, Liu S, Wang C, Wang J, Ji Y.

    10/22/2016
    Survival, differentiation, and neuroprotective mechanisms of human stem cells complexed with neurotrophin-3-releasing pharmacologically active microcarriers in an ex vivo model of Parkinson's disease.

    Survival, differentiation, and neuroprotective mechanisms of human stem cells complexed with neurotrophin-3-releasing pharmacologically active microcarriers in an ex vivo model of Parkinson's disease.
    Daviaud N, Garbayo E, Sindji L, Martínez-Serrano A, Schiller PC, Montero-Menei CN., Free PMC Article

    08/15/2015
    No differences in plasma BDNF, NGF, NT3, NT4 and GDNF were found between autism spectrum disorders and control.

    Circulating levels of neurotrophic factors in autism spectrum disorders.
    Rodrigues DH, Rocha NP, Sousa LF, Barbosa IG, Kummer A, Teixeira AL.

    03/21/2015
    NT-3 expression was found in axons of olfactory bulb.

    Differential localization of NT-3 and TrpM5 in glomeruli of the olfactory bulb of mice.
    Rolen SH, Salcedo E, Restrepo D, Finger TE., Free PMC Article

    12/20/2014
    genetic variation in the NTF3 gene is related to susceptibility to emotional side effects in response to methylphenidate treatment in Korean children with ADHD.

    Neurotrophin 3 genotype and emotional adverse effects of osmotic-release oral system methylphenidate (OROS-MPH) in children with attention-deficit/hyperactivity disorder.
    Park S, Kim BN, Kim JW, Shin MS, Cho SC, Kim JH, Son JW, Shin YM, Chung US, Han DH.

    11/8/2014
    NT-3 appears to promote growth of metastatic breast cancer cells in the brain

    Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis.
    Louie E, Chen XF, Coomes A, Ji K, Tsirka S, Chen EI., Free PMC Article

    11/16/2013
    Patients with mastocytosis featured elevated serum levels of NGF, NT-3, and NT-4. TrkA, TrkB, and TrkC expression was also elevated.

    Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.
    Peng WM, Maintz L, Allam JP, Raap U, Gütgemann I, Kirfel J, Wardelmann E, Perner S, Zhao W, Fimmers R, Walgenbach K, Oldenburg J, Schwartz LB, Novak N.

    11/2/2013
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