| Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model. | Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model.
Chen Y, Steiner S, Hagedorn C, Kollar S, Pliego-Mendieta A, Haberecker M, Plock J, Britschgi C, Planas-Paz L, Pauli C. | 06/5/2024 |
| A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. | A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas.
Lippai Z, Péterfia B, Papp G, Dezső K, Bedics G, Pápai Z, Lamers MH, Kuin RC, Szuhai K, Sápi Z. | 05/1/2024 |
| TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression. | TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression.
Zhang Y, Huang Z, Li K, Xie G, Feng Y, Wang Z, Li N, Liu R, Ding Y, Wang J, Yang J, Jia Z., Free PMC Article | 01/16/2024 |
| Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls. | Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls.
Moura MS, Costa J, Velasco V, Kommoss F, Oliva E, Le Loarer F, McCluggage WG, Razack R, Treilleux I, Mills A, Longacre T, Devouassoux-Shisheboran M, Hostein I, Azmani R, Blanchard L, Hartog C, Soubeyran I, Khalifa E, Croce S. | 01/15/2024 |
| NTRK1 Spitz melanoma presenting clinically as an angioma. | NTRK1 Spitz melanoma presenting clinically as an angioma.
Arasheben A, Desai M, Lee MP, Love J, Chow C, Kerstetter J, Elsensohn A. | 08/23/2023 |
| Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV. | Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV.
Pacifico P, Testa G, Amodeo R, Mainardi M, Tiberi A, Convertino D, Arevalo JC, Marchetti L, Costa M, Cattaneo A, Capsoni S., Free PMC Article | 08/11/2023 |
| Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors. | Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors.
Naito Y, Mishima S, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, Kato M, Kenmotsu H, Kodera Y, Komine K, Koyama T, Maeda O, Miyachi M, Nishihara H, Nishiyama H, Ohga S, Okamoto W, Oki E, Ono S, Sanada M, Sekine I, Takano T, Tao K, Terashima K, Tsuchihara K, Yatabe Y, Yoshino T, Baba E., Free PMC Article | 07/12/2023 |
| Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines. | Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines.
Jiao B, Zhang M, Zhang C, Cao X, Liu B, Li N, Sun J, Zhang X., Free PMC Article | 04/26/2023 |
| Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer. | Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer.
Doan C, Aouizerat BE, Ye Y, Dang D, Asam K, Bhattacharya A, Howard T, Patel YK, Viet DT, Figueroa JD, Zhong JF, Thomas CM, Morlandt AB, Yu G, Callahan NF, Allen CT, Grandhi A, Herford AS, Walker PC, Nguyen K, Kidd SC, Lee SC, Inman JC, Slater JM, Viet CT., Free PMC Article | 09/24/2022 |
| NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway. | NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway.
Fang CN, Tan HQ, Song AB, Jiang N, Liu QR, Song T. | 07/23/2022 |
| Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells. | Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells.
Suzuki C, Nishiyama A, Arai S, Tange S, Tajima A, Tanimoto A, Fukuda K, Takumi Y, Kotani H, Takeuchi S, Yanagimura N, Ohtsubo K, Yamamoto N, Omori K, Yano S., Free PMC Article | 07/16/2022 |
| Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. | Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis.
Li S, Hu HY, Xu JJ, Feng ZK, Sun YQ, Chen X, Yang K, Li YZ, Zhang DL., Free PMC Article | 06/18/2022 |
| Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCgamma as an analgesic drug target. | Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target.
Moraes BC, Ribeiro-Filho HV, Roldão AP, Toniolo EF, Carretero GPB, Sgro GG, Batista FAH, Berardi DE, Oliveira VRS, Tomasin R, Vieceli FM, Pramio DT, Cardoso AB, Figueira ACM, Farah SC, Devi LA, Dale CS, de Oliveira PSL, Schechtman D. | 05/14/2022 |
| Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells. | Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells.
Trouvilliez S, Cicero J, Lévêque R, Aubert L, Corbet C, Van Outryve A, Streule K, Angrand PO, Völkel P, Magnez R, Brysbaert G, Mysiorek C, Gosselet F, Bourette R, Adriaenssens E, Thuru X, Lagadec C, de Ruyck J, Orian-Rousseau V, Le Bourhis X, Toillon RA., Free PMC Article | 04/9/2022 |
| Tropomyosin Receptor Kinase Inhibitors for the Treatment of TRK Fusion Cancer. | Tropomyosin Receptor Kinase Inhibitors for the Treatment of TRK Fusion Cancer.
Laetsch TW, Hong DS. | 04/2/2022 |
| Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion-Positive Lung Cancers. | Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion-Positive Lung Cancers.
Drilon A, Tan DSW, Lassen UN, Leyvraz S, Liu Y, Patel JD, Rosen L, Solomon B, Norenberg R, Dima L, Brega N, Shen L, Moreno V, Kummar S, Lin JJ., Free PMC Article | 03/26/2022 |
| NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism. | NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism.
Garrido MP, Vallejos C, Girardi S, Gabler F, Selman A, López F, Vega M, Romero C., Free PMC Article | 03/19/2022 |
| The beta-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19. | The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19.
Usai C, Gibbons JM, Pade C, Li W, Jacobs SRM, McKnight Á, Kennedy PTF, Gill US., Free PMC Article | 02/12/2022 |
| NTRK and other recently described kinase fusion positive uterine sarcomas: A review of a group of rare neoplasms. | NTRK and other recently described kinase fusion positive uterine sarcomas: A review of a group of rare neoplasms.
Croce S, Hostein I, McCluggage WG. | 02/12/2022 |
| NTRK1 gene-related congenital insensitivity to pain with anhidrosis: a nationwide multicenter retrospective study. | NTRK1 gene-related congenital insensitivity to pain with anhidrosis: a nationwide multicenter retrospective study.
Echaniz-Laguna A, Altuzarra C, Verloes A, De La Banda MGG, Quijano-Roy S, Tudorache RA, Jaxybayeva A, Myrzaliyeva B, Tazir M, Vallat JM, Francou B, Urtizberea JA. | 02/5/2022 |
| Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer's Disease. | Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer's Disease.
Barabás K, Kobolák J, Godó S, Kovács T, Ernszt D, Kecskés M, Varga C, Jánosi TZ, Fujiwara T, Kusumi A, Téglási A, Dinnyés A, Ábrahám IM., Free PMC Article | 02/5/2022 |
| Targeted DNA profiling and the prevalence of NTRK aberrations in Chinese patients with head and neck cancer. | Targeted DNA profiling and the prevalence of NTRK aberrations in Chinese patients with head and neck cancer.
Xu J, Wang R, Wang T, Wang T, Gu D, He Y, Shu Y, Chen R, Liu L. | 02/5/2022 |
| Oncogenic NTRK fusion in congenital spinal cord glioblastoma: sequencing directs treatment. | Oncogenic NTRK fusion in congenital spinal cord glioblastoma: sequencing directs treatment.
Andrews JP, Coleman C, Hastings C, Sun PP. | 01/8/2022 |
| NTRK fusion in Japanese colorectal adenocarcinomas. | NTRK fusion in Japanese colorectal adenocarcinomas.
Yamashiro Y, Kurihara T, Hayashi T, Suehara Y, Yao T, Kato S, Saito T., Free PMC Article | 12/11/2021 |
| Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer's Disease. | Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer's Disease.
Kropf E, Fahnestock M., Free PMC Article | 11/22/2021 |