| TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco. | TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Benmansour R, Tagajdid MR, El Hamzaoui H, Fjouji S, Doghmi N, Houba A, Belbacha I, Elkochri S, Aabi R, Elannaz H, Laraqui A, El Mchichi B, Chmitah T, Touil N, Ennibi K, Eljaoudi R, Elmir E, Amine Lahlou I, Oumzil H., Free PMC Article | 08/16/2024 |
| Integrative Multiomics and Regulatory Network Analyses Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E Virus Infection. | Integrative Multiomics and Regulatory Network Analyses Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E Virus Infection.
Gupta S, Singh P, Tasneem A, Almatroudi A, Rahmani AH, Dohare R, Parveen S., Free PMC Article | 02/11/2023 |
| IFN-beta1b induces OAS3 to inhibit EV71 via IFN-beta1b/JAK/STAT1 pathway. | IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway.
Zheng B, Zhou X, Tian L, Wang J, Zhang W., Free PMC Article | 10/22/2022 |
| OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced Jak1Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis. | OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY. | 10/15/2022 |
| Zika virus employs the host antiviral RNase L protein to support replication factory assembly. | Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Whelan JN, Parenti NA, Hatterschide J, Renner DM, Li Y, Reyes HM, Dong B, Perez ER, Silverman RH, Weiss SR., Free PMC Article | 12/11/2021 |
| Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people. | Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.
Liu M, Jin HS, Park S. | 08/21/2021 |
| Length dependent activation of OAS proteins by dsRNA. | Length dependent activation of OAS proteins by dsRNA.
Wang Y, Holleufer A, Gad HH, Hartmann R. | 07/31/2021 |
| Genetic analysis of a Taiwanese family identifies a DMRT3-OAS3 interaction that is involved in human sexual differentiation through the regulation of ESR1 expression. | Genetic analysis of a Taiwanese family identifies a DMRT3-OAS3 interaction that is involved in human sexual differentiation through the regulation of ESR1 expression.
Tsai CL, Tsai CN, Lee YS, Wang HS, Lee LY, Lin CY, Yang SY, Chao A. | 04/24/2021 |
| Our study revealed a heterozygous mutation in OAS3 from a Chinese Juvenile-onset open-angle glaucoma family. And this mutation showed a deleterious effect to the expression of OAS3. | Exome Sequencing Reveals a Heterozygous OAS3 Mutation in a Chinese Family With Juvenile-Onset Open-Angle Glaucoma.
Xiao X, Huang C, Cao Y, Chen S, Xu Y, Chen H, Pang C, Zhang M. | 01/25/2020 |
| The dependence on expression of ZAP antiviral protein (ZAP), 2'-5'-oligoadenylate synthetase (OAS3) and 2-5A-dependent ribonuclease (RNAseL) for CpG/UpA-mediated attenuation and the variable and often low level expression of these pathway proteins in certain cell types. | The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.
Odon V, Fros JJ, Goonawardane N, Dietrich I, Ibrahim A, Alshaikhahmed K, Nguyen D, Simmonds P., Free PMC Article | 12/14/2019 |
| Genetic risk scores were calculated by summing the risk alleles of 4 selected single nucleotide polymorphisms, CDKAL1 rs7754840 and rs9460546, HHEX rs5015480, and OAS3 | Alcohol Intake Interacts with CDKAL1, HHEX, and OAS3 Genetic Variants, Associated with the Risk of Type 2 Diabetes by Lowering Insulin Secretion in Korean Adults.
Park S, Liu M, Kang S. | 11/9/2019 |
| We propose the following model for the selective targeting of exogenous RNA; OAS3 activated by the exogenous RNA releases 2'-5'-oligoadenylates (2-5A), which in turn converts latent RNase L to an active dimer. | Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway.
Nogimori T, Nishiura K, Kawashima S, Nagai T, Oishi Y, Hosoda N, Imataka H, Kitamura Y, Kitade Y, Hoshino SI., Free PMC Article | 08/31/2019 |
| Data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages. | OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.
Lee WB, Choi WY, Lee DH, Shim H, Kim-Ha J, Kim YJ., Free PMC Article | 06/22/2019 |
| The carriage frequency of 2'-5'-oligoadenylate synthetase 3 (OAS3) S381R CC genotypes and the occurrence of C allele in severe EV71infected cases are higher than in mild cases. Severe cases have significant higher levels of Interferon-gamma in GC+GG genotypes compared to CC genotype. Carrying C allele of the OAS3 S381R gene is susceptibility factor in the development of severe EV71 infection among Chinese children. | Oligoadenylate synthetase 3 S381R gene polymorphism is associated with severity of EV71 infection in Chinese children.
Liu Y, Liu P, Liu S, Guo Y, He H, Yang C, Song J, Zhang N, Cheng J, Chen Z. | 06/15/2019 |
| Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. | Mitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production.
Yang Y, Xiong S, Cai B, Luo H, Dong E, Li Q, Ji G, Zhao C, Wen Y, Wei Y, Yang H., Free PMC Article | 11/10/2018 |
| Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population. | Identified OAS3 gene variants associated with coexistence of HBsAg and anti-HBs in chronic HBV infection.
Wang S, Wang J, Fan MJ, Li TY, Pan H, Wang X, Liu HK, Lin QF, Zhang JG, Guan LP, Zhernakova DV, O'Brien SJ, Feng ZR, Chang L, Dai EH, Lu JH, Xi HL, Zeng Z, Yu YY, Wang BB., Free PMC Article | 11/10/2018 |
| The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection. | Association of the OAS3 rs1859330 G/A genetic polymorphism with severity of enterovirus-71 infection in Chinese Han children.
Tan Y, Yang T, Liu P, Chen L, Tian Q, Guo Y, He H, Liu Y, Chen Z. | 08/5/2017 |
| we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2 | Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Sams AJ, Dumaine A, Nédélec Y, Yotova V, Alfieri C, Tanner JE, Messer PW, Barreiro LB., Free PMC Article | 06/24/2017 |
| Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3 | Nuclear import sequence identification in hOAS3 protein.
Malaguarnera L, Nunnari G, Di Rosa M. | 04/22/2017 |
| OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation. | Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR., Free PMC Article | 07/30/2016 |
| Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients. | Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection.
Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. | 05/28/2016 |
| By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock. | High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue.
Simon-Loriere E, Lin RJ, Kalayanarooj SM, Chuansumrit A, Casademont I, Lin SY, Yu HP, Lert-Itthiporn W, Chaiyaratana W, Tangthawornchaikul N, Tangnararatchakit K, Vasanawathana S, Chang BL, Suriyaphol P, Yoksan S, Malasit P, Despres P, Paul R, Lin YL, Sakuntabhai A. | 03/12/2016 |
| Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk. | Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk.
Sava GP, Speedy HE, Di Bernardo MC, Dyer MJ, Holroyd A, Sunter NJ, Marr H, Mansouri L, Deaglio S, Karabon L, Frydecka I, Jamroziak K, Woszczyk D, Juliusson G, Smedby KE, Jayne S, Majid A, Wang Y, Dearden C, Hall AG, Mainou-Fowler T, Jackson GH, Summerfield G, Harris RJ, Pettitt AR, Allsup DJ, Bailey JR, Pratt G, Pepper C, Fegan C, Rosenquist R, Catovsky D, Allan JM, Houlston RS., Free PMC Article | 05/9/2015 |
| The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L. | The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.
Ibsen MS, Gad HH, Thavachelvam K, Boesen T, Desprès P, Hartmann R., Free PMC Article | 01/24/2015 |
| The results suggest that OAS1-OAS3-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection. | Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.
Alagarasu K, Honap T, Damle IM, Mulay AP, Shah PS, Cecilia D. | 08/31/2013 |