| Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma. | Combined OPCML and AXL Expression as a Prognostic Marker and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
Khamko R, Wasenang W, Daduang J, Settasatian C, Limpaiboon T., Free PMC Article | 05/14/2022 |
| OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation. | OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
Khamko R, Daduang J, Settasatian C, Limpaiboon T., Free PMC Article | 02/19/2022 |
| Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers. | Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.
Antony J, Zanini E, Birtley JR, Gabra H, Recchi C. | 01/1/2022 |
| Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer. | Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer.
Lian B, Li H, Liu Y, Chai D, Gao Y, Zhang Y, Zhou J, Li J. | 10/9/2021 |
| LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. | LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML.
Fang X, Dong Y, Yang R, Wei L. | 10/10/2020 |
| The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling. | The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.
Zhang Z, Ye M, Li Q, You Y, Yu H, Ma Y, Mei L, Sun X, Wang L, Yue W, Li R, Li J, Zhang D. | 09/19/2020 |
| Human opioid-binding protein/cell adhesion molecule (OPCML) is expressed in many tissues and localizes to the plasma membrane. It is a putative tumor suppressor that acts on receptor tyrosine kinases, influencing cell cycle arrest, apoptosis, and migration. Its expression is silenced epigenetically in cancer, inferring potential diagnostic, prognostic, and therapeutic roles. [Review] | OPCML: A Promising Biomarker and Therapeutic Avenue.
Simovic I, Castaño-Rodríguez N, Kaakoush NO. | 08/1/2020 |
| OPCML promoter was found to be hypermethylated in esophageal squamous cell carcinoma (ESCC) samples. Hypermethylation of the studied OPCML promoter produced no effect on OPCML protein expression in Grade 2 tumors but revealed downregulation in Grade 3 tumors. Deranged OPCML expression may lead to high-grade ESCC as well as epigenetically regulated genes that may alter the Wnt/beta-catenin and TGF-beta-Smad pathways in ... | Epigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation.
Singh V, Singh AP, Sharma I, Singh LC, Sharma J, Borthakar BB, Rai AK, Kataki AC, Kapur S, Saxena S. | 07/20/2019 |
| OPCML and PTPRG, coordinate to repress AXL-dependent oncogenic signalling. | The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
Antony J, Zanini E, Kelly Z, Tan TZ, Karali E, Alomary M, Jung Y, Nixon K, Cunnea P, Fotopoulou C, Paterson A, Roy-Nawathe S, Mills GB, Huang RY, Thiery JP, Gabra H, Recchi C., Free PMC Article | 05/18/2019 |
| Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines | The Tumor-Suppressor Protein OPCML Potentiates Anti-EGFR- and Anti-HER2-Targeted Therapy in HER2-Positive Ovarian and Breast Cancer.
Zanini E, Louis LS, Antony J, Karali E, Okon IS, McKie AB, Vaughan S, El-Bahrawy M, Stebbing J, Recchi C, Gabra H. | 07/21/2018 |
| Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. | Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.
Xing X, Cai W, Ma S, Wang Y, Shi H, Li M, Jiao J, Yang Y, Liu L, Zhang X, Chen M., Free PMC Article | 06/24/2017 |
| OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci | Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer.
Wu Y, Davison J, Qu X, Morrissey C, Storer B, Brown L, Vessella R, Nelson P, Fang M., Free PMC Article | 05/27/2017 |
| OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. | Effect of OPCML gene on the biological behavior of gastric cancer cell line AGS.
Wang LH, Chu FF, Ren DH, Du XL. | 09/10/2016 |
| the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens | DNA methylation level of OPCML and SFRP1: a potential diagnostic biomarker of cholangiocarcinoma.
Amornpisutt R, Proungvitaya S, Jearanaikoon P, Limpaiboon T. | 10/31/2015 |
| The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. | Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects.
Ye M, Parente F, Li X, Perryman MB, Zelante L, Wynshaw-Boris A, Chen J, Grossfeld P. | 12/20/2014 |
| Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. | Detection of circulating methylated opioid binding protein/cell adhesion molecule-like gene as a biomarker for ovarian carcinoma.
Zhou F, Ma M, Tao G, Chen X, Xie W, Wang Y, Cao X. | 06/14/2014 |
| The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. | The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer.
McKie AB, Vaughan S, Zanini E, Okon IS, Louis L, de Sousa C, Greene MI, Wang Q, Agarwal R, Shaposhnikov D, Wong JL, Gungor H, Janczar S, El-Bahrawy M, Lam EW, Chayen NE, Gabra H., Free PMC Article | 01/26/2013 |
| A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population | OPCML gene as a schizophrenia susceptibility locus in Thai population.
Panichareon B, Nakayama K, Thurakitwannakarn W, Iwamoto S, Sukhumsirichart W. | 09/15/2012 |
| opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma | Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma.
Duarte-Pereira S, Paiva F, Costa VL, Ramalho-Carvalho J, Savva-Bordalo J, Rodrigues A, Ribeiro FR, Silva VM, Oliveira J, Henrique R, Jerónimo C. | 11/19/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 11/10/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 11/10/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 11/10/2011 |
| OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. | OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.
Cui Y, Ying Y, van Hasselt A, Ng KM, Yu J, Zhang Q, Jin J, Liu D, Rhim JS, Rha SY, Loyo M, Chan AT, Srivastava G, Tsao GS, Sellar GC, Sung JJ, Sidransky D, Tao Q., Free PMC Article | 01/21/2010 |
| OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. | OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma.
Ye F, Zhang SF, Xie X, Lu WG. | 01/21/2010 |
| loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation | Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma.
Chen H, Ye F, Zhang J, Lu W, Cheng Q, Xie X. | 01/21/2010 |