| The authors used structural, computational and functional approaches to show that a crucial acidic chamber near the nucleotide-binding pocket in human P2X3 receptors accommodates divalent ions in two distinct modes in the absence and presence of nucleotide. | Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ., Free PMC Article | 02/29/2020 |
| Druggable negative allosteric site of P2X3 receptors. | Druggable negative allosteric site of P2X3 receptors.
Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R, Hattori M, Yu Y., Free PMC Article | 08/18/2018 |
| conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R | Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating.
Stephan G, Kowalski-Jahn M, Zens C, Schmalzing G, Illes P, Hausmann R., Free PMC Article | 11/11/2017 |
| P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain. | P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.
Ding S, Zhu L, Tian Y, Zhu T, Huang X, Zhang X., Free PMC Article | 10/14/2017 |
| P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy. | Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy.
Zhou X, Ma LM, Xiong Y, Huang H, Yuan JX, Li RH, Li JN, Chen YM. | 03/11/2017 |
| X-ray crystal structures of the human P2X3 receptor in apo/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states | X-ray structures define human P2X(3) receptor gating cycle and antagonist action.
Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E., Free PMC Article | 02/25/2017 |
| there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients. | Potential Involvement of P2 Receptors in the Pathological Processes of Hyperthyroidism: A Pilot Study.
Hong W, Li G, Nie Y, Zou L, Zhang X, Liu S, Li G, Xu H, Zhang CP, Liang S. | 01/28/2017 |
| Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel. | Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.
Shcherbatko A, Foletti D, Poulsen K, Strop P, Zhu G, Hasa-Moreno A, Melton Witt J, Loo C, Krimm S, Pios A, Yu J, Brown C, Lee JK, Stroud R, Rajpal A, Shelton D., Free PMC Article | 12/17/2016 |
| Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC) therapy. | P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients.
Maynard JP, Lee JS, Sohn BH, Yu X, Lopez-Terrada D, Finegold MJ, Goss JA, Thevananther S., Free PMC Article | 10/1/2016 |
| Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits | Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors.
Kowalski M, Hausmann R, Schmid J, Dopychai A, Stephan G, Tang Y, Schmalzing G, Illes P, Rubini P. | 08/27/2016 |
| Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection. | Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome.
Liu HT, Chen SH, Chancellor MB, Kuo HC., Free PMC Article | 05/21/2016 |
| The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder. | Localization of P2X receptor subtypes 2, 3 and 7 in human urinary bladder.
Svennersten K, Hallén-Grufman K, de Verdier PJ, Wiklund NP, Poljakovic M., Free PMC Article | 03/5/2016 |
| sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns | Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder.
Sterle I, Zupančič D, Romih R., Free PMC Article | 11/7/2015 |
| esophagitis increases mRNA expressions of P2X3 and P2X7 receptors accompanied by up-regulation of TRPV1 and neurotrophic factors (NGF and GDNF). | Evidence for up-regulation of purinergic receptor genes associating with TRPV1 receptors and neurotrophic factors in the inflamed human esophagus.
Shieh KR, Yang SC, Tseng HL, Yi CH, Liu TT, Chen CL. | 07/25/2015 |
| Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening | Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.
Kowalski M, Hausmann R, Dopychai A, Grohmann M, Franke H, Nieber K, Schmalzing G, Illes P, Riedel T., Free PMC Article | 07/4/2015 |
| TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve | Distribution of TRPVs, P2X3, and parvalbumin in the human nodose ganglion.
Sato D, Sato T, Urata Y, Okajima T, Kawamura S, Kurita M, Takahashi K, Nanno M, Watahiki A, Kokubun S, Shimizu Y, Kasahara E, Shoji N, Sasano T, Ichikawa H. | 04/4/2015 |
| Data indicate that Markov models are suitable to simulate agonist antagonist interactions at fast desensitizing receptors such as the P2X3R. | Agonist antagonist interactions at the rapidly desensitizing P2X3 receptor.
Helms N, Kowalski M, Illes P, Riedel T., Free PMC Article | 08/30/2014 |
| ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis. | Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis.
Liñán-Rico A, Wunderlich JE, Grants IS, Frankel WL, Xue J, Williams KC, Harzman AE, Enneking JT, Cooke HJ, Christofi FL., Free PMC Article | 05/24/2014 |
| Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors. | Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+.
Li M, Silberberg SD, Swartz KJ., Free PMC Article | 12/21/2013 |
| An early and broad expression of P2X3 receptors was found in prenatal dorsal root ganglion neurons. | Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion.
Pan A, Wu H, Li M, Lu D, He X, Yi X, Yan XX, Li Z., Free PMC Article | 07/13/2013 |
| HEK 293 cells are not permissive for stable P2X3 expression afer a significant time-dependent cell loss; often used in a recmbinant expression system, HEK cells represent a limiting permissive environment for P2X3 receptors. | P2X3 receptor expression by HEK cells conditions their survival.
Apicella L, Fabbretti E., Free PMC Article | 07/13/2013 |
| Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article] | Regulation of P2X3 receptor structure and function.
Fabbretti E, Nistri A. | 06/8/2013 |
| The effects of single alanine substitutions of amino acid residues in the supposed ATP binding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs. | Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch.
Riedel T, Wiese S, Leichsenring A, Illes P. | 11/3/2012 |
| one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors | ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.
Hausmann R, Bodnar M, Woltersdorf R, Wang H, Fuchs M, Messemer N, Qin Y, Günther J, Riedel T, Grohmann M, Nieber K, Schmalzing G, Rubini P, Illes P., Free PMC Article | 07/21/2012 |
| Amino acid residues constituting the agonist binding site of the human P2X3 receptor. | Amino acid residues constituting the agonist binding site of the human P2X3 receptor.
Bodnar M, Wang H, Riedel T, Hintze S, Kato E, Fallah G, Gröger-Arndt H, Giniatullin R, Grohmann M, Hausmann R, Schmalzing G, Illes P, Rubini P., Free PMC Article | 03/5/2011 |