| Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics. | Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics.
Dance A, Fernandes J, Toussaint B, Vaillant E, Boutry R, Baron M, Loiselle H, Balkau B, Charpentier G, Franc S, Ibberson M, Marre M, Gernay M, Fadeur M, Paquot N, Vaxillaire M, Boissel M, Amanzougarene S, Derhourhi M, Khamis A, Froguel P, Bonnefond A., Free PMC Article | 02/2/2024 |
| Exploring bias in platelet P2Y1 signalling: Host defence versus haemostasis. | Exploring bias in platelet P2Y(1) signalling: Host defence versus haemostasis.
Pan D, Ladds G, Rahman KM, Pitchford SC., Free PMC Article | 01/26/2024 |
| Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation. | Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation.
Su C, Zhang Z, Chen J, Tian M, Wu C, Zhang T., Free PMC Article | 02/11/2023 |
| Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy. | Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy.
Gil-Redondo JC, Iturri J, Ortega F, Pérez-Sen R, Weber A, Miras-Portugal MT, Toca-Herrera JL, Delicado EG., Free PMC Article | 04/13/2021 |
| Contribution of P2X4 Receptors to CNS Function and Pathophysiology. | Contribution of P2X4 Receptors to CNS Function and Pathophysiology.
Montilla A, Mata GP, Matute C, Domercq M., Free PMC Article | 02/20/2021 |
| Extracellular ATP, P2Rs, ecto-nucleotidases, adenosine, and P1Rs are basic elements of the purinergic signaling network and fundamental pillars of inflammation. | Purinergic signaling, DAMPs, and inflammation.
Di Virgilio F, Sarti AC, Coutinho-Silva R. | 08/12/2020 |
| We conclude that P2Y1 and P2X receptors have non-redundant, synergistic functions in the regulation of T cell activation | Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation.
Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG., Free PMC Article | 02/22/2020 |
| high-risk gene-gene interactions among TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 were associated with higher platelet activation, and independently associated with higher risk of carotid stenosis in ischemic stroke patients. | The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.
Yi X, Lin J, Zhou Q, Huang R, Chai Z., Free PMC Article | 04/6/2019 |
| Genomic association study identified deleterious rare variants in P2RY1 in patients with ischemic stroke. | Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients.
Janicki PK, Eyileten C, Ruiz-Velasco V, Sedeek KA, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura-Kawasawa Y, Mirowska-Guzel D, Postula M., Free PMC Article | 07/21/2018 |
| Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization. | Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization.
Kim SA, Choi HS, Ahn SG., Free PMC Article | 02/24/2018 |
| predominant role of P2Y1 receptors in human embryonic stem cells and a transition of P2Y-IP3R coupling in derived cardiovascular progenitor cells are responsible for the differential Ca(2+) mobilization between these cells. | Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells.
Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT., Free PMC Article | 11/11/2017 |
| The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC progression in a VHL-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC signals against RCC progression. | Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia.
Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C. | 09/9/2017 |
| these data highlight a key role of the P2Y1/PI3Kbeta axis in endothelial cell proliferation downstream of ecto-F1-ATPase activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection. | PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.
Castaing-Berthou A, Malet N, Radojkovic C, Cabou C, Gayral S, Martinez LO, Laffargue M. | 08/5/2017 |
| ALIX regulates P2Y1 degradation. | ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.
Dores MR, Grimsey NJ, Mendez F, Trejo J., Free PMC Article | 07/22/2017 |
| There is increased expression of P2Y1 receptors in the rectosigmoid mucosa of diarrhea-predominant irritable bowel syndrome patients. | P2Y1, P2Y2, and TRPV1 Receptors Are Increased in Diarrhea-Predominant Irritable Bowel Syndrome and P2Y2 Correlates with Abdominal Pain.
Luo Y, Feng C, Wu J, Wu Y, Liu D, Wu J, Dai F, Zhang J. | 07/8/2017 |
| High extracellular NaCl induces priming of the NLRP3 inflammasome in RPE cells, in part via P2Y1 receptor signaling | P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells.
Prager P, Hollborn M, Steffen A, Wiedemann P, Kohen L, Bringmann A., Free PMC Article | 06/10/2017 |
| aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1) and glycoprotein gene (GPIIIa) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS | Platelet receptor Gene (P2Y12, P2Y1) and platelet glycoprotein Gene (GPIIIa) polymorphisms are associated with antiplatelet drug responsiveness and clinical outcomes after acute minor ischemic stroke.
Yi X, Zhou Q, Wang C, Lin J, Liu P, Fu C. | 04/22/2017 |
| Early neurological deterioration (END) occurred significantly more frequently in patients with aspirin resistance (AR) or high-risk interactive genotypes. Moreover, AR and high-risk interactive genotypes were independently associated with END. | Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients.
Yi X, Wang C, Zhou Q, Lin J., Free PMC Article | 02/25/2017 |
| Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy. | Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K., Free PMC Article | 07/16/2016 |
| Antibody EL2Ab binds to and exhibits P2Y1R-dependent function-blocking activity in the context of platelets. | Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.
Karim ZA, Vemana HP, Alshbool FZ, Lin OA, Alshehri AM, Javaherizadeh P, Paez Espinosa EV, Khasawneh FT., Free PMC Article | 04/16/2016 |
| P2Y1 couples to and activates TRPV4. PKC inhibitors prevented P2Y1 receptor activation of TRPV4. | P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.
Rajasekhar P, Poole DP, Liedtke W, Bunnett NW, Veldhuis NA., Free PMC Article | 03/19/2016 |
| P2Y1 receptors are a potential pharmacological target leading smooth muscle relaxation to treat spasticity in colonic motor disorders. | α,β-meATP mimics the effects of the purinergic neurotransmitter in the human and rat colon.
Martínez-Cutillas M, Gil V, Gallego D, Mañé N, Clavé P, Martín MT, Jiménez M. | 10/31/2015 |
| crystal structures of the human P2Y1R in complex with a nucleotide antagonist MRS2500 at 2.7 A resolution, and with a non-nucleotide antagonist BPTU at 2.2 A resolution | Two disparate ligand-binding sites in the human P2Y1 receptor.
Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B., Free PMC Article | 10/3/2015 |
| Data indicate that ATP-evoked Hoechst 33258 uptake was dependent on activation of P2Y receptors P2Y1 and P2Y2. | Selective permeabilization of cervical cancer cells to an ionic DNA-binding cytotoxin by activation of P2Y receptors.
Bukhari M, Deng H, Jones N, Towne Z, Woodworth CD, Samways DS., Free PMC Article | 08/8/2015 |
| This study shows that Up4A is a potent native agonist for P2Y1R and SK-channel activation in human and mouse colon. | Uridine adenosine tetraphosphate is a novel neurogenic P2Y1 receptor activator in the gut.
Durnin L, Hwang SJ, Kurahashi M, Drumm BT, Ward SM, Sasse KC, Sanders KM, Mutafova-Yambolieva VN., Free PMC Article | 04/18/2015 |