| Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages. | Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.
Klaver D, Gander H, Frena B, Amato M, Thurnher M., Free PMC Article | 03/14/2024 |
| Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages. | Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.
Andersen LL, Huang Y, Urban C, Oubraham L, Winheim E, Stafford C, Nagl D, O'Duill F, Ebert T, Engleitner T, Paludan SR, Krug A, Rad R, Hornung V, Pichlmair A., Free PMC Article | 12/5/2023 |
| P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies? | P2Y(11)/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?
Klaver D, Thurnher M., Free PMC Article | 10/6/2023 |
| The P2Y11 receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses. | The P2Y(11) receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses.
Klaver D, Gander H, Dobler G, Rahm A, Thurnher M., Free PMC Article | 10/1/2022 |
| The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes. | The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes.
Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Aytan D, Shen Y, Junger WG., Free PMC Article | 10/30/2021 |
| High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1. | High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1.
Viste R, Viken MK, Lie BA, Juvodden HT, Nordstrand SEH, Thorsby PM, Rootwelt T, Kornum BR, Knudsen-Heier S., Free PMC Article | 10/30/2021 |
| Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. | Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse.
Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Junger WG., Free PMC Article | 03/27/2021 |
| The Human G Protein-Coupled ATP Receptor P2Y11 Is Associated With IL-10 Driven Macrophage Differentiation. | The Human G Protein-Coupled ATP Receptor P2Y(11) Is Associated With IL-10 Driven Macrophage Differentiation.
Gruenbacher G, Gander H, Rahm A, Dobler G, Drasche A, Troppmair J, Nussbaumer W, Thurnher M., Free PMC Article | 10/24/2020 |
| Study of eight narcolepsy-associated P2RY11 mutations showed decreased surface expression of the R307W P2Y11 mutant and a surface expression similar to wild type for the other seven mutants in HEK293 cells. | Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations.
Dommer MW, Dreisig K, Kornum BR. | 06/27/2020 |
| Our study provides evidence of a protective mechanism of P2Y11R antagonist NF340 against cytokine-induced inflammation. Therefore, targeting P2Y11R could have potential therapeutic implication in the treatment of rheumatoid arthritis. | P2Y11 receptor antagonist NF340 ameliorates inflammation in human fibroblast-like synoviocytes: An implication in rheumatoid arthritis.
Gao F, Li X. | 05/16/2020 |
| findings suggest that LPS and ATP accumulation in the circulation of sepsis patients suppresses T cells by promoting inappropriate P2Y11 receptor stimulation that impairs T cell metabolism and functions. | Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors.
Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG., Free PMC Article | 10/19/2019 |
| These results also demonstrated a beneficial role of P2Y11R in human cardiac fibroblasts during Hypoxia/Reoxygenation (H/R) and strongly support the hypothesis that P2Y11R is a modulator of Ischemia/Reperfusion injury. | Stimulation of P2Y11 receptor modulates cardiac fibroblasts secretome toward immunomodulatory and protective roles after Hypoxia/Reoxygenation injury.
Lefort C, Benoist L, Chadet S, Piollet M, Heraud A, Babuty D, Baron C, Ivanes F, Angoulvant D. | 09/14/2019 |
| this paper provides evidence that P2Y11 receptor inhibits P2X7 receptor pore formation but not calcium signaling which occurs independently of P2Y11 receptor signaling | Human P2Y(11) Expression Level Affects Human P2X7 Receptor-Mediated Cell Death.
Dreisig K, Sund L, Dommer MW, Kristensen NP, Boddum K, Viste R, Fredholm S, Odum N, Jäättelä M, Skov S, Kornum BR., Free PMC Article | 08/17/2019 |
| a major role for P2X7R and P2Y11R in ATP-mediated inhibition of tumor-derived endothelial cell migration, is reported. | Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling.
Avanzato D, Genova T, Fiorio Pla A, Bernardini M, Bianco S, Bussolati B, Mancardi D, Giraudo E, Maione F, Cassoni P, Castellano I, Munaron L., Free PMC Article | 05/26/2018 |
| these results show hepatocellular carcinoma-specific expression of the P2Y11 receptor and its critical role in mediating ATP-inducing Ca2+ signalling and regulating cancer cell migration | Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells.
Khalid M, Brisson L, Tariq M, Hao Y, Guibon R, Fromont G, Mortadza SAS, Mousawi F, Manzoor S, Roger S, Jiang LH., Free PMC Article | 03/24/2018 |
| Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy. | Rare missense mutations in P2RY11 in narcolepsy with cataplexy.
Degn M, Dauvilliers Y, Dreisig K, Lopez R, Pfister C, Pradervand S, Rahbek Kornum B, Tafti M. | 07/22/2017 |
| Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells. | Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.
Chadet S, Ivanes F, Benoist L, Salmon-Gandonnière C, Guibon R, Velge-Roussel F, Babuty D, Baron C, Roger S, Angoulvant D. | 09/12/2015 |
| Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair. | Activation of P2RY11 and ATP release by lipoxin A4 restores the airway surface liquid layer and epithelial repair in cystic fibrosis.
Higgins G, Buchanan P, Perriere M, Al-Alawi M, Costello RW, Verriere V, McNally P, Harvey BJ, Urbach V. | 10/4/2014 |
| the physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1-P2Y11 receptor interaction. | Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor.
Haas M, Shaaban A, Reiser G. | 06/21/2014 |
| vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages | Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.
Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S., Free PMC Article | 10/26/2013 |
| P2Y11 receptor mediates interferon gamma-induced IL-6 production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma induced skin inflammatory conditions | Involvement of P2Y₁₁ receptor in IFN-γ-induced IL-6 production in human keratinocytes.
Ishimaru M, Tsukimoto M, Harada H, Kojima S. | 09/28/2013 |
| P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers. | Purinergic receptors expressed in human skeletal muscle fibres.
Bornø A, Ploug T, Bune LT, Rosenmeier JB, Thaning P., Free PMC Article | 07/13/2013 |
| The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population. | TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
Han F, Lin L, Li J, Aran A, Dong SX, An P, Zhao L, Li QY, Yan H, Wang JS, Gao HY, Li M, Gao ZC, Strohl KP, Mignot E., Free PMC Article | 07/14/2012 |
| Extracellular NAD stimulates mesenchymal stem cell functions through activation of P2Y11 receptor. | Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling.
Fruscione F, Scarfì S, Ferraris C, Bruzzone S, Benvenuto F, Guida L, Uccelli A, Salis A, Usai C, Jacchetti E, Ilengo C, Scaglione S, Quarto R, Zocchi E, De Flora A. | 10/22/2011 |
| Common variants in P2RY11 are associated with narcolepsy. | Common variants in P2RY11 are associated with narcolepsy.
Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E., Free PMC Article | 02/26/2011 |