| Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth. | Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.
Kaluz S, Zhang Q, Kuranaga Y, Yang H, Osuka S, Bhattacharya D, Devi NS, Mun J, Wang W, Zhang R, Goodman MM, Grossniklaus HE, Van Meir EG., Free PMC Article | 08/26/2024 |
| Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease. | Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.
Cao J, Zhong Q, Huang Y, Zhu M, Wang Z, Xiong Z. | 03/15/2024 |
| P4HA1 expression and function in esophageal squamous cell carcinoma. | P4HA1 expression and function in esophageal squamous cell carcinoma.
Gou W, Song B, Yang Y., Free PMC Article | 01/29/2024 |
| Prolyl 4-hydroxylase P4HA1 Mediates the Interplay Between Glucose Metabolism and Stemness in Pancreatic Cancer Cells. | Prolyl 4-hydroxylase P4HA1 Mediates the Interplay Between Glucose Metabolism and Stemness in Pancreatic Cancer Cells.
Cao X, Cao Y, Zhao H, Wang P, Zhu Z. | 06/23/2023 |
| P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma. | P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma.
Sato K, Sano D, Takahashi H, Kuwahara T, Aizawa Y, Aoyama J, Nojima Y, Hatano T, Arai Y, Nishimura G, Hatakeyama H, Oridate N. | 06/2/2023 |
| Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation. | Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation.
Zhu M, Yan T, Zhu S, Weng F, Zhu K, Wang C, Guo C. | 05/14/2023 |
| P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression. | P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.
Gou W, Yang Y, Shan Q, Xia S, Ma Y. | 04/24/2023 |
| P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression. | P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression.
Zhou R, Qiu L, Zhou L, Geng R, Yang S, Wu J. | 03/15/2023 |
| Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit alpha members in breast cancer. | Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.
Li M, Wang Q, Zheng Q, Wu L, Zhao B, Wu Y. | 03/26/2022 |
| Comprehensive Analysis of Gene Expression Profiles Identifies a P4HA1-Related Gene Panel as a Prognostic Model in Colorectal Cancer Patients. | Comprehensive Analysis of Gene Expression Profiles Identifies a P4HA1-Related Gene Panel as a Prognostic Model in Colorectal Cancer Patients.
Chen Z, Chen M, Xue Z, Zhu X. | 02/12/2022 |
| Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis. | Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA-miRNA-P4HA1 Regulatory Axis.
Hu Z, Song F, Hu Y, Liao T., Free PMC Article | 09/11/2021 |
| Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma. | Overexpression of P4HA1 Is Correlated with Poor Survival and Immune Infiltrates in Lung Adenocarcinoma.
Zhou H, He Y, Li L, Wu C, Hu G., Free PMC Article | 05/8/2021 |
| Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. | Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls.
Eriksson J, Le Joncour V, Jahkola T, Juteau S, Laakkonen P, Saksela O, Hölttä E., Free PMC Article | 02/6/2021 |
| High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent-free survival in head and neck squamous cell carcinoma. | High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent-free survival in head and neck squamous cell carcinoma.
Li Q, Shen Z, Wu Z, Shen Y, Deng H, Zhou C, Liu H., Free PMC Article | 12/19/2020 |
| Findings show that prolyl 4-hydroxylase subunit alpha 1 (P4HA1) can enhance hypoxia-inducible factor 1alpha (HIF1alpha) stability, indicating a positive feedback loop between HIF1alpha and P4HA1 in pancreatic ductal adenocarcinoma (PDAC). | P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer.
Cao XP, Cao Y, Li WJ, Zhang HH, Zhu ZM. | 07/11/2020 |
| Diagnostic and Prognostic Values of P4HA1 Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer | Identification of Potential Diagnostic and Prognostic Values of P4HA1 Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer.
Li M, Wu F, Zheng Q, Wu Y, Wu Y. | 05/23/2020 |
| Collagen prolyl 4-hydroxylase alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. Inhibition of P4HA1 sensitizes TNBC to the chemotherapeutic agent docetaxel and doxorubicin in xenografts and patient-derived models. Increased P4HA1 expression correlates with short relapse-free survival in TNBC patients who received chemotherapy. | Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.
Xiong G, Stewart RL, Chen J, Gao T, Scott TL, Samayoa LM, O'Connor K, Lane AN, Xu R., Free PMC Article | 01/12/2019 |
| miR-122 inhibited migration, invasion, epithelial mesenchymal transition, and metastasis in peritoneal cavity of ovarian cancer cells by targeting P4HA1. | MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells.
Duan Y, Dong Y, Dang R, Hu Z, Yang Y, Hu Y, Cheng J. | 12/22/2018 |
| High expression of P4HA1 was correlated with the malignancy of gliomas and could serve as a prognostic indicator for patients with high-grade gliomas | Identification of P4HA1 as a prognostic biomarker for high-grade gliomas.
Hu WM, Zhang J, Sun SX, Xi SY, Chen ZJ, Jiang XB, Lin FH, Chen ZH, Chen YS, Wang J, Yang QY, Guo CC, Mou YG, Chen ZP, Zeng J, Sai K. | 08/4/2018 |
| Our study indicates that P4HA1 plays a pivotal role in the process of GSC-EC transdifferentiation and the structural formation of vascular BMs. | Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane.
Zhou Y, Jin G, Mi R, Zhang J, Zhang J, Xu H, Cheng S, Zhang Y, Song W, Liu F., Free PMC Article | 03/31/2018 |
| we report compound heterozygous frameshift and splice site mutations in P4HA1 that impair but not abolish C-P4H alpha(I) activity. The maternal P4HA1 exon 12 splice donor site mutation causes an internally deleted C-P4H alpha(I) predicted to completely lack catalytic activity. two nucleic acid insertion in exon 9 results in a premature stop in the exon 9 P4HA1 splice form. | P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.
Zou Y, Donkervoort S, Salo AM, Foley AR, Barnes AM, Hu Y, Makareeva E, Leach ME, Mohassel P, Dastgir J, Deardorff MA, Cohn RD, DiNonno WO, Malfait F, Lek M, Leikin S, Marini JC, Myllyharju J, Bönnemann CG., Free PMC Article | 10/14/2017 |
| Findings suggest that the catalytic domain of collagen prolyl 4-hydroxylases (CP4Hs) recognizes the cis conformation of the prolyl peptide bond. | Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond.
Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT., Free PMC Article | 05/27/2017 |
| Thus, we conclude that miR-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA. | MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA.
Feng G, Shi H, Li J, Yang Z, Fang R, Ye L, Zhang W, Zhang X. | 08/13/2016 |
| Studies indicate P4HA1 copy number gain in a subset of metastatic prostate tumors and its expression is also regulated by microRNA-124. | The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression.
Chakravarthi BV, Pathi SS, Goswami MT, Cieślik M, Zheng H, Nallasivam S, Arekapudi SR, Jing X, Siddiqui J, Athanikar J, Carskadon SL, Lonigro RJ, Kunju LP, Chinnaiyan AM, Palanisamy N, Varambally S., Free PMC Article | 06/6/2015 |
| Overexpression of miR-122 markedly attenuated the expression of P4HA1 via targeting a binding site located at 3'-UTR of P4HA1 mRNA | miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression.
Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, Gandhi CR, Li S., Free PMC Article | 08/31/2013 |