| Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases. | Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
Kervarrec T, Westphal D, Pissaloux D, Legrand M, Tirode F, Neuhart A, Drouot F, Becker JC, Macagno N, Seris A, Jouary T, Beltzung F, Jullie ML, Harms PW, Cribier B, Mourah S, Jouenne F, Fromont G, Louveau B, Mancini M, Kazakov DV, de la Fouchardière A, Battistella M. | 09/6/2024 |
| Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma. | Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
Xu MH, Zheng YM, Liang BG, Xu WX, Cao J, Wang P, Dong ZY, Zhou CH, Sun HC, Ren N, Ke AW, Shen YH., Free PMC Article | 07/18/2024 |
| Targetable leukaemia dependency on noncanonical PI3Kgamma signalling. | Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
Luo Q, Raulston EG, Prado MA, Wu X, Gritsman K, Whalen KS, Yan K, Booth CAG, Xu R, van Galen P, Doench JG, Shimony S, Long HW, Neuberg DS, Paulo JA, Lane AA. | 06/26/2024 |
| PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway. | PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.
Chen M, Pan L, Chen D, Wu Y, Ye J, Li K, Zhang N, Xu J. | 05/1/2024 |
| A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children. | A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children.
Scorrano G, D'Onofrio G, Accogli A, Severino M, Buchert R, Kotzaeridou U, Iapadre G, Farello G, Iacomino M, Dono F, Di Francesco L, Fiorile MF, La Bella S, Corsello A, Calì E, Di Rosa G, Gitto E, Verrotti A, Fortuna S, Soler MA, Chiarelli F, Oehl-Jaschkowitz B, Haack TB, Zara F, Striano P, Salpietro V. | 12/14/2023 |
| PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis. | PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis.
Jokl E, Mullan AF, Simpson K, Birchall L, Pearmain L, Martin K, Pritchett J, Raza S, Shah R, Hodson NW, Williams CJ, Camacho E, Zeef L, Donaldson I, Athwal VS, Hanley NA, Piper Hanley K. | 12/6/2023 |
| A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity. | A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
Assing K, Jørgensen SE, Sandgaard KS, De Keukeleere K, B-Hansen M, Petersen MS, Hartling UB, Vaal TMK, Nielsen C, Jakobsen MA, Watt E, Adams S, Hao Q, Fagerberg C, Mogensen TH., Free PMC Article | 11/22/2023 |
| Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer. | Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer.
Pyo JS, Min KW, Oh IH, Lim DH, Son BK. | 11/18/2023 |
| Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma. | Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma.
Surabhi RP, Rajendran S, Srikanth Swamy Swaroop B, Murugan S, Shanmugasundaram G, Joseph LD, Pitani R, Babu PS, Suresh K R, Venkatraman G. | 11/7/2023 |
| PAK1 and Therapy Resistance in Melanoma. | PAK1 and Therapy Resistance in Melanoma.
Kichina JV, Maslov A, Kandel ES., Free PMC Article | 11/7/2023 |
| PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry. | PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry.
Li CF, Chan TC, Fang FM, Yu SC, Huang HY., Free PMC Article | 08/16/2023 |
| PAK1 copy number in breast cancer-Associations with proliferation and molecular subtypes. | PAK1 copy number in breast cancer-Associations with proliferation and molecular subtypes.
Skjervold AH, Valla M, Ytterhus B, Bofin AM., Free PMC Article | 06/30/2023 |
| PAK1 Inhibition Suppresses the Proliferation, Migration and Invasion of Glioma Cells. | PAK1 Inhibition Suppresses the Proliferation, Migration and Invasion of Glioma Cells.
Yi Q, Chen T, Zhou K, Ma Q, Sun Z, Shi H. | 03/19/2023 |
| Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1. | Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1.
Li M, Zhou J, Zhang Z, Li J, Wang F, Ma L, Tian X, Mao Z, Yang Y., Free PMC Article | 12/31/2022 |
| [Blocking PAK1 kinase activity promotes the differentiation of acute megakaryocytic leukemia cells and induces their apoptosis]. | [Blocking PAK1 kinase activity promotes the differentiation of acute megakaryocytic leukemia cells and induces their apoptosis].
Wang SJ, Wang CQ, Hu XT, Yu XR, Fu CL., Free PMC Article | 09/10/2022 |
| Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis. | Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Merz KE, Tunduguru R, Ahn M, Salunkhe VA, Veluthakal R, Hwang J, Bhattacharya S, McCown EM, Garcia PA, Zhou C, Oh E, Yoder SM, Elmendorf JS, Thurmond DC., Free PMC Article | 04/9/2022 |
| PAK1 and PAK2 in cell metabolism regulation. | PAK1 and PAK2 in cell metabolism regulation.
Kořánová T, Dvořáček L, Grebeňová D, Röselová P, Obr A, Kuželová K. | 04/2/2022 |
| Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway. | Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.
Liu WW, Hu J, Wang R, Han Q, Liu Y, Wang S. | 03/12/2022 |
| Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression. | Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression.
Chen A, Liu Z, Wu Q, Li H. | 02/26/2022 |
| Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice. | Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice.
Cheng C, Hou Y, Zhang Z, Wang Y, Lu L, Zhang L, Jiang P, Gao S, Fang Q, Zhu C, Gao J, Liu X, Xie W, Jia Z, Xu Z, Gao X, Chai R. | 01/22/2022 |
| Amyloid-beta induced membrane damage instigates tunneling nanotube-like conduits by p21-activated kinase dependent actin remodulation. | Amyloid-β induced membrane damage instigates tunneling nanotube-like conduits by p21-activated kinase dependent actin remodulation.
Dilna A, Deepak KV, Damodaran N, Kielkopf CS, Kagedal K, Ollinger K, Nath S. | 01/1/2022 |
| A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation. | A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation.
Frick A, Khare V, Jimenez K, Dammann K, Lang M, Krnjic A, Gmainer C, Baumgartner M, Mesteri I, Gasche C., Free PMC Article | 12/25/2021 |
| Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. | Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Feng X, Zhang H, Meng L, Song H, Zhou Q, Qu C, Zhao P, Li Q, Zou C, Liu X, Zhang Z., Free PMC Article | 12/4/2021 |
| DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. | DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.
Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XY, Liu CY, Fang KH, Han X, Wang S, Wang X, Xu M, Bhattacharyya A, Guo X, Lin M, Liu Y., Free PMC Article | 10/9/2021 |
| Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity. | Blockage of PAK1 alleviates the proliferation and invasion of NSCLC cells via inhibiting ERK and AKT signaling activity.
Song P, Song B, Liu J, Wang X, Nan X, Wang J. | 09/18/2021 |