| GEMIN4 Variants: Risk Profiling, Bioinformatics, and Dynamic Simulations Uncover Susceptibility to Bladder Carcinoma. | GEMIN4 Variants: Risk Profiling, Bioinformatics, and Dynamic Simulations Uncover Susceptibility to Bladder Carcinoma.
Mohamed AS, Salama AF, Sabaa MA, Toraih E, Elshazli RM. | 04/30/2024 |
| Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome. | Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome.
Altassan R, Qudair A, Alokaili R, Alhasan K, Faqeih EA, Alhashem A, Alowain M, Alsayed M, Rahbeeni Z, Albadi L, Alkuraya FS, Anderson EN, Rajan D, Pandey UB. | 09/24/2022 |
| A Novel GEMIN4 Variant in a Consanguineous Family Leads to Neurodevelopmental Impairment with Severe Microcephaly, Spastic Quadriplegia, Epilepsy, and Cataracts. | A Novel GEMIN4 Variant in a Consanguineous Family Leads to Neurodevelopmental Impairment with Severe Microcephaly, Spastic Quadriplegia, Epilepsy, and Cataracts.
Aldhalaan H, AlBakheet A, AlRuways S, AlMutairi N, AlNakiyah M, AlGhofaili R, Cardona-Londoño KJ, Alahmadi KO, AlQudairy H, AlRasheed MM, Colak D, Arold ST, Kaya N., Free PMC Article | 04/30/2022 |
| Association of GEMIN4 gene polymorphisms with the risk of colorectal cancer in the Polish population. | Association of GEMIN4 gene polymorphisms with the risk of colorectal cancer in the Polish population.
Cieślak A, Galita G, Mik M, Dziki Ł, Dziki A, Sokołowski I, Popławski T, Majsterek I. | 04/23/2022 |
| We selected five single nucleotide polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and lung cancer risk. This is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk. | Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers.
Fang X, Yin Z, Li X, Xia L, Zhou B., Free PMC Article | 08/5/2017 |
| These findings indicate that GEMIN4 functions as a novel coregulator of the MR. | GEMIN4 functions as a coregulator of the mineralocorticoid receptor.
Yang J, Fuller PJ, Morgan J, Shibata H, Clyne CD, Young MJ. | 12/26/2015 |
| the association between the GEMIN4 gene and the risk of prostate cancer | Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population.
Liu J, Liu J, Wei M, He Y, Liao B, Liao G, Li H, Huang J., Free PMC Article | 09/22/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.
Boni V, Zarate R, Villa JC, Bandrés E, Gomez MA, Maiello E, Garcia-Foncillas J, Aranda E. | 09/15/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.
Wilker EH, Baccarelli A, Suh H, Vokonas P, Wright RO, Schwartz J., Free PMC Article | 04/7/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (4) articlesMicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.
Lin J, Horikawa Y, Tamboli P, Clague J, Wood CG, Wu X. Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.
Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA, Wu X. | 12/2/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation of a common AGO1 variant with lung cancer risk: a two-stage case-control study.
Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, Lin J, Habuchi T, Wu X. | 01/11/2009 |
| A canonical nuclear import sequence in the N-terminus of Gemin4 was identified. | Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4.
Lorson MA, Dickson AM, Shaw DJ, Todd AG, Young EC, Morse R, Wolstencroft C, Lorson CL, Young PJ., Free PMC Article | 01/21/2010 |
| Gemin3 and Gemin4 function in Sm core assembly and correlate the activity of this pathway with Spinal Muscular Atrophy. | Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.
Shpargel KB, Matera AG., Free PMC Article | 01/21/2010 |
| zinc-finger proteins were identified as HCAP1-interacting proteins | HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.
Di Y, Li J, Zhang Y, He X, Lu H, Xu D, Ling J, Huo K, Wan D, Li YY, Gu J. | 01/21/2010 |
| A haplotype of HCAP1 with minor alleles at 5 single nucleotide polymorphisms may be related to cancer susceptibility: its expression causes up-regulation of genes involved in cell growth and down-regulation of genes involved in apoptosis and DNA repair. | Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B.
Wan D, He M, Wang J, Qiu X, Zhou W, Luo Z, Chen J, Gu J. | 01/21/2010 |